AD-36
362765
222511402
2008-06-29T18:58:44Z
DOI bot
6652755
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{{Taxobox | color=violet
| virus_group = i
| familia = ''[[Adenoviridae]]''
| genus = ''[[Mastadenovirus]]''
| species = ''[[Human adenovirus D]]'' (HAdV-D)
| serotype = '''Human adenovirus 36''' (HAdV-36)
}}
'''Human adenovirus 36''' (HAdV-36) or '''AD-36''' is one of 51 types of [[adenovirus]]es known to infect [[human]]s. It was first shown to be associated with [[obesity]] in [[chicken]]s by Dr. [[Nikhil Dhurandhar]].<ref name="dhurandhar2000">{{cite journal | first=N V | last=Dhurandhar | coauthors=B A Israel, J M Kolesar, G F Mayhew, M E Cook, R L Atkinson | title=Increased adiposity in animals due to a human virus | year=2000 | journal=International Journal of Obesity | volume=24 | pages=989–996 | doi=10.1038/sj.ijo.0801319}}</ref><ref name="dhurandhar2006">{{cite journal | last=Whigham | first=Leah D. | coauthors=Barbara A. Israel, and Richard L. Atkinson | title=Adipogenic potential of multiple human adenoviruses in vivo and in vitro in animals | journal=Am J Physiol Regul Integr Comp Physiol | volume=290 | pages=R190–R194 | year=2006}}</ref>
There has been a positive correlation between body fat and the presence of AD-36 [[antibodies]] in the blood (International Journal of Obesity vol29 pages 281-286). Previous research showed that chicken or mice injected with similar types of viruses show a statistically significant weight gain.<ref name="dhurandhar2000"/>
To date, AD-36 is the only human adenovirus that has been linked with human obesity, present in 30% of obese humans and 11% of nonobese humans.<ref name="Atkinson">{{cite journal |author=Atkinson RL |title=Viruses as an etiology of obesity |journal=Mayo Clin. Proc. |volume=82 |issue=10 |pages=1192–8 |year=2007 |pmid=17908526 |doi=}}</ref> AD-36 also causes obesity in chickens, mice, rats, and monkeys.<ref name="Atkinson"/>
AD-36 infection can induce [[cellular differentiation]] of [[3T3-L1]] [[preadipocyte]]s and [[stem cell]]s derived from human [[adipose tissue]].<ref name="Rogers">{{cite journal |author=Rogers PM, Fusinski KA, Rathod MA, ''et al'' |title=Human adenovirus Ad-36 induces adipogenesis via its E4 orf-1 gene |journal=Int J Obes (Lond) |volume= 32|issue= |pages=397|year=2007 |pmid=17984979 |doi=10.1038/sj.ijo.0803748}}</ref>
==References==
{{reflist}}
==External links==
*[http://www.webmd.com/diet/news/20040805/fat-virus-could-obesity-be-contagious "The Fat Virus: Could Obesity Be Contagious?"] at [[WebMD]]
*[http://news.bbc.co.uk/1/hi/health/854584.stm "Can a virus make you fat?"] at [[BBC News]]
*[http://www.scienceblog.com/cms/contagious_obesity_identifying_the_human_adenoviruses_that_may_make_us_fat_9901 "Contagious obesity? Identifying the human adenoviruses that may make us fat"] at [[Science Blog]]
*[http://www.biologynews.net/archives/2007/08/20/common_virus_may_contribute_to_obesity_in_some_people_new_study_shows.html "Common virus may contribute to obesity in some people, new study shows"] at [[Biology News Net]]
[[Category:Viruses]]
[[Category:Medical conditions related to obesity]]
[[Category:Microbiology]]
[[pl:Adenowirus Ad-36]]