ADAMTS5
1674402
132538521
2007-05-21T21:59:34Z
130.216.140.84
{{protein
| Name = ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)
| caption =
| image =
| width =
| HGNCid = 221
| Symbol = ADAMTS5
| AltSymbols =
| EntrezGene = 11096
| OMIM = 605007
| RefSeq = NM_007038
| UniProt = Q9UNA0
| PDB =
| ECnumber =
| Chromosome = 21
| Arm = q
| Band = 22.1
| LocusSupplementaryData = -q22
}}
'''ADAMTS5''' (aggrecanase) is an [[enzyme]] that destroys [[cartilage]] in [[mouse|mice]]. Its discovery may lead to progress in [[human]] [[arthritis]] research. This enzyme may also be involved in cartilage deterioration in humans. It has been isolated and identified by [[Australia|Australian]] scientists in [[Sydney]]. ADAMTS5 has been indicated as being important in early [[osteoarthritis]].
== External links ==
*[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=304135 Rat Genome Database]
{{med-stub}}
{{Metalloproteinases}}
[[Category:EC 3.4.24]]