ADAMTS5 1674402 132538521 2007-05-21T21:59:34Z 130.216.140.84 {{protein | Name = ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2) | caption = | image = | width = | HGNCid = 221 | Symbol = ADAMTS5 | AltSymbols = | EntrezGene = 11096 | OMIM = 605007 | RefSeq = NM_007038 | UniProt = Q9UNA0 | PDB = | ECnumber = | Chromosome = 21 | Arm = q | Band = 22.1 | LocusSupplementaryData = -q22 }} '''ADAMTS5''' (aggrecanase) is an [[enzyme]] that destroys [[cartilage]] in [[mouse|mice]]. Its discovery may lead to progress in [[human]] [[arthritis]] research. This enzyme may also be involved in cartilage deterioration in humans. It has been isolated and identified by [[Australia|Australian]] scientists in [[Sydney]]. ADAMTS5 has been indicated as being important in early [[osteoarthritis]]. == External links == *[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=304135 Rat Genome Database] {{med-stub}} {{Metalloproteinases}} [[Category:EC 3.4.24]]