Acquired pure red cell aplasia
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2008-05-02T09:15:11Z
PipepBot
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robot Adding: [[it:Aplasia eritroide pura]]
{{DiseaseDisorder infobox |
Name = Acquired pure red cell aplasia |
ICD10 = {{ICD10|D|60||d|60}} |
ICD9 = {{ICD9|284.8}} |
ICDO = |
Image = |
Caption = |
OMIM = |
OMIM_mult = |
MedlinePlus = |
eMedicineSubj = med |
eMedicineTopic = 1967 |
DiseasesDB = 29063 |
MeshID = D012010 |
}}
'''Acquired pure red cell aplasia''' (or PRCA) refers to a type of [[anemia]] affecting the precursors to [[red blood cells]] but not to [[white blood cells]]. In PRCA, the [[bone marrow]] ceases to produce red blood cells.
==Causes==
Pure red cell aplasia is regarded as an [[autoimmune disease]]. It may also be a manifestation of [[thymoma]]. It may also be as a result of viral infections such as [[HIV]], [[Herpes simplex virus|herpes]], [[parvovirus B19]] ([[Fifth disease]]), or [[Hepatitis#Viral|hepatitis]]. Association of pure red cell aplasia with T large granular lymphocyte leukemia is also well recognized, especially in China.<ref>{{cite web |url=http://jcp.bmj.com/cgi/content/abstract/51/9/672 |title=Association of pure red cell aplasia with T large granular lymphocyte leukaemia -- Kwong and Wong 51 (9): 672 -- Journal of Clinical Pathology |accessdate=2007-11-07 |format= |work=}}</ref> Many cases of PRCA are considered [[idiopathic]] in that there is no discernible cause detected.
It can be associated with the administration of [[erythropoietin]].<ref name="pmid15459301">{{cite journal |author=Bennett CL, Luminari S, Nissenson AR, ''et al'' |title=Pure red-cell aplasia and epoetin therapy |journal=[[N. Engl. J. Med.]] |volume=351 |issue=14 |pages=1403–8 |year=2004 |pmid=15459301 |doi=10.1056/NEJMoa040528 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=15459301&promo=ONFLNS19}}</ref>
==Treatment==
PRCA is considered an autoimmune disease as it will respond to [[immunosuppressant]] treatment such as [[ciclosporin]]. It has also been shown to respond to treatments with [[Rituxan]].
==See also==
* [[Diamond-Blackfan anemia]] (genetic red cell aplasia)
* [[aplastic anemia]] (aplasia affecting other bone marrow cells as well)
==References==
{{reflist}}
==External links==
* [http://www.aamds.org Aplastic Anemia & MDS International Foundation]
{{Hematology}}
[[Category:Hematology]]
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[[de:Pure Red Cell Aplasia]]
[[it:Aplasia eritroide pura]]