Acute coronary syndrome
2138187
221330205
2008-06-24T01:33:03Z
Arcadian
104523
/* Diagnosis */ image
{{Infobox_Disease |
Name = {{PAGENAME}} |
Image = |
Caption = |
DiseasesDB = |
ICD10 = |
ICD9 = |
ICDO = |
OMIM = |
MedlinePlus = |
eMedicineSubj = emerg |
eMedicineTopic = 31 |
MeshID = D054058 |
}}
An '''acute coronary syndrome''' (ACS) is a set of signs and symptoms, usually a combination of [[chest pain]] and other features, interpreted as being the result of abruptly decreased blood flow to the [[heart]] (cardiac [[ischemia]]); the most common cause for this is the disruption of [[atherosclerotic plaque]] in an epicardial [[coronary artery]]. The subtypes of acute coronary syndrome include [[Angina_pectoris#Unstable_angina|unstable angina]] (UA, not associated with heart muscle damage), and two forms of [[myocardial infarction]] (heart attack), in which heart muscle is damaged. These types are named according to the appearance of the [[electrocardiogram]] (ECG/EKG) as ''non-ST segment elevation myocardial infarction'' (NSTEMI) and ''ST segment elevation myocardial infarction'' (STEMI).
ACS should be distinguished from [[angina pectoris|stable angina]], which develops during exertion and resolves at rest. In contrast with stable angina, unstable angina occurs suddenly, often at rest or with minimal exertion, or at lesser degrees of exertion than the individual's previous angina ("crescendo angina"). New onset angina is also considered unstable angina, since it suggests a new problem in a coronary artery.
==Signs and symptoms==
The cardinal sign of decreased blood flow to the heart is chest pain experienced as tightness around the chest and radiating to the left arm and the left angle of the jaw. This may be associated with [[diaphoresis]] (sweating), [[nausea]] and [[vomiting]], as well as [[dyspnea|shortness of breath]]. In many cases, the sensation is "atypical", with pain experienced in different ways or even being completely absent (which is more likely in female patients and those with [[diabetes mellitus|diabetes]]). Some may report [[palpitation]]s, anxiety or a sense of impending doom and a feeling of being acutely ill.
==Diagnosis==
[[Image:ACS scheme.jpg|right|thumb|300px|Classification of [[acute coronary syndrome]]s.<ref name="Alpert-2000">{{cite journal | author=Alpert JS, Thygesen K, Antman E, Bassand JP. | title=Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. | journal=J Am Coll Cardiol | year=2000 | volume=36 | issue=3 | pages=959–69 | pmid=10987628 | doi=10.1016/S0735-1097(00)00804-4}}</ref>]]
===Electrocardiogram===
In the setting of acute chest pain, the [[electrocardiogram]] is the investigation that most reliably distinguishes between various causes.<ref>{{cite journal |author=Chun AA, McGee SR |title=Bedside diagnosis of coronary artery disease: a systematic review |journal=Am. J. Med. |volume=117 |issue=5 |pages=334–43 |year=2004 |pmid=15336583 |doi=10.1016/j.amjmed.2004.03.021}}</ref> If this indicates acute heart damage (elevation in the ''ST segment'', new [[left bundle branch block]]), treatment for a heart attack (in the form of [[angioplasty]] or [[thrombolysis]], is indicated immediately (see below). In the absence of such changes, it is not possible to immediately distinguish between unstable angina and NSTEMI.
===Imaging and blood tests===
As it is only one of the many potential causes of [[chest pain]], the patient usually has a number of tests in the [[emergency department]], such as a [[chest X-ray]], [[blood test]]s (including [[cardiac marker|myocardial markers]] such as [[troponin]] I or T, and a [[D-dimer]] if a [[pulmonary embolism]] is suspected), and telemetry (monitoring of the heart rhythm).
===Prediction scores===
The ACI-TIPI score can be used to aid diagnosis; using 7 variables from the admission record, this score predicts crudely which patients are likely to have myocardial ischemia.<ref name="pmid2072767">{{cite journal |author=Selker HP, Griffith JL, D'Agostino RB |title=A tool for judging coronary care unit admission appropriateness, valid for both real-time and retrospective use. A time-insensitive predictive instrument (TIPI) for acute cardiac ischemia: a multicenter study |journal=Medical care |volume=29 |issue=7 |pages=610–27 |year=1991 |pmid=2072767 |doi=}}</ref>
==Prognosis==
===TIMI score===
The [[TIMI]] risk score can identify high risk patients<ref name="pmid10938172">{{cite journal |author=Antman EM, Cohen M, Bernink PJ, ''et al'' |title=The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making |journal=JAMA |volume=284 |issue=7 |pages=835–42 |year=2000 |pmid=10938172 |doi=}}</ref> and has been independently validated.<ref name="pmid16365321">{{cite journal |author=Pollack CV, Sites FD, Shofer FS, Sease KL, Hollander JE |title=Application of the TIMI risk score for unstable angina and non-ST elevation acute coronary syndrome to an unselected emergency department chest pain population |journal=Academic emergency medicine : official journal of the Society for Academic Emergency Medicine |volume=13 |issue=1 |pages=13–8 |year=2006 |pmid=16365321 |doi=10.1197/j.aem.2005.06.031}}</ref><ref name="pmid16934646">{{cite journal |author=Chase M, Robey JL, Zogby KE, Sease KL, Shofer FS, Hollander JE |title=Prospective validation of the Thrombolysis in Myocardial Infarction Risk Score in the emergency department chest pain population |journal=Annals of emergency medicine |volume=48 |issue=3 |pages=252–9 |year=2006 |pmid=16934646 |doi=10.1016/j.annemergmed.2006.01.032}}</ref>
===Biomarkers for diagnosis===
The aim of diagnostic markers is to identify patients with ACS even when there is no evidence of myocyte necrosis.
*Ischemia-Modified Albumin (IMA) - In cases of Ischemia - Albumin undergoes a conformational change and loses its ability to bind transitional metals (copper or cobalt). IMA can be used to assess the proportion of modified albumin in ischemia. Its use is limited to ruling out ischemia rather than a diagnostic test for the occurrence of ischemia.
*Myeloperoxidase (MPO) - The levels of circulating MPO, a leukocyte enzyme, elevate early after ACS and can be used as an early marker for the condition.
*Glycogen Phosphorylase Isoenzyme BB-([[GPBB]]) is an early marker of cardiac ischemia and is one of three [[isoenzymes|isoenzyme]] of Glycogen Phosphorylase.
*[[Troponin]] is a late cardiac marker of ACS
===Biomarkers for Risk Stratification===
The aim of prognostic markers is to reflect different components of pathophysiology of ACS. For example:
*Natriuretic peptide - Both B-type natriuretic peptide (BNP) and N-terminal Pro BNP can be applied to predict the risk of death and heart failure following ACS.
*Monocyte chemo attractive protein (MCP)-1 - has been shown in a number of studies to identify patients with a higher risk of adverse outcomes after ACS.
==Treatment==
===STEMI===
{{main|Myocardial infarction}}
If the ECG confirms changes suggestive of [[myocardial infarction]] (ST elevations in specific leads, a new left bundle branch block or a true posterior MI pattern), [[thrombolytics]] may be administered or [[angioplasty|primary coronary angioplasty]] may be performed. In the former, medication is injected that stimulates [[fibrinolysis]], destroying blood clots obstructing the [[coronary artery|coronary arteries]]. In the latter, a flexible catheter is passed via the femoral or radial [[arteries]] and advanced to the heart to identify blockages in the coronaries. When occlusions are found, they can be intervened upon mechanically with [[angioplasty]] and perhaps [[stent]] deployment if a lesion, termed the ''culprit'' lesion, is thought to be causing myocardial damage.
===NSTEMI and NSTE-ACS===
If the ECG does not show typical changes, the term "non-ST segment elevation ACS" is applied. The patient may still have suffered a "non-ST elevation MI" (NSTEMI). The accepted management of unstable angina and acute coronary syndrome is therefore empirical treatment with [[aspirin]], [[heparin]] (usually a [[low-molecular weight heparin]] such as [[enoxaparin]]) and [[clopidogrel]], with intravenous [[Glyceryl trinitrate (pharmacology)|glyceryl trinitrate]] and [[opioid]]s if the pain persists.
A blood test is generally performed for cardiac troponins twelve hours after onset of the pain. If this is positive, [[coronary angiography]] is typically performed on an urgent basis, as this is highly predictive of a heart attack in the near-future. If the troponin is negative, a treadmill exercise test or a thallium scintigram may be requested.
==Prevention==
{{main|Coronary heart disease}}
Acute coronary syndrome often reflects a degree of damage to the coronaries by [[atherosclerosis]]. Primary prevention of atherosclerosis is controlling the risk factors: healthy eating, exercise, treatment for [[hypertension]] and [[diabetes mellitus|diabetes]], avoiding [[tobacco smoking|smoking]] and controlling [[cholesterol]] levels); in patients with significant risk factors, [[aspirin]] has been shown to reduce the risk of cardiovascular events. Secondary prevention is discussed in [[myocardial infarction]].
==References==
{{Refimprove|date=January 2008}}
{{reflist|2}}
{{Heart diseases}}
[[Category:Medical emergencies]]
[[Category:Ischemic heart diseases]]
[[de:Akutes Koronarsyndrom]]
[[it:Sindrome coronarica acuta]]
[[ja:急性冠症候群]]
[[pl:Ostre zespoły wieńcowe]]
[[ur:تاجی متلازمۂ حاد]]