Adenylate kinase 1375635 219427237 2008-06-15T04:39:41Z SieBot 4005189 robot Adding: [[he:אדנילאט קינאז]] {{Protein |Name=Adenylate kinase 1 |image= |caption= |Symbol=AK1 |AltSymbols= |HGNCid=361 |Chromosome=9 |Arm=q |Band=34.1 |LocusSupplementaryData= |ECnumber=2.7.4.3 |OMIM=103000 |EntrezGene=203 |RefSeq=NM_000476 |UniProt=P00568 |PDB= }} '''Adenylate kinase''' (also known as '''ADK''' or '''myokinase''') is a [[phosphotransferase]] [[enzyme]] that catalyzes the interconversion of adenine nucleotides, and plays an important role in cellular energy [[homeostasis]] (see the [[Homeostasis#Biological homeostasis|"Biological homeostasis" section of "Homeostasis"]]). The reaction catalyzed is: 2 [[Adenosine diphosphate|ADP]] ⇔ [[Adenosine triphosphate|ATP]] + [[Adenosine monophosphate|AMP]] The equilibrium constant in the direction written is 0.44. Thus, the ΔG<sup>o</sup> for this reaction is close to zero. In muscle of a variety of species of vertebrates and invertebrates, the concentration of [[Adenosine triphosphate|ATP]] is typically 7-10 times that of [[ADP]], and usually greater than 100 times that of [[AMP]] <ref>Beis I., and Newsholme E. A. (1975). The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates. Biochem J 152, 23-32.</ref>. The rate of [[oxidative phosphorylation]] is controlled by the availability of ADP. Thus, the mitochondrion attempts to keep [[Adenosine triphosphate|ATP]] levels high due to the combined action of adenylate kinase and the controls on [[oxidative phosphorylation]]. ===References=== {{Reflist}} ==External links== * {{MeshName|Adenylate+kinase}} [[Category:Cellular respiration]] [[Category:EC 2.7.4]] {{transferase-stub}} {{Kinases}} {{Mitochondrial enzymes}} [[ca:Mioquinasa]] [[de:Adenylat-Kinase]] [[es:Adenilato kinasa]] [[he:אדנילאט קינאז]] [[uk:Аденілаткіназа]]