Adenylate kinase
1375635
219427237
2008-06-15T04:39:41Z
SieBot
4005189
robot Adding: [[he:אדנילאט קינאז]]
{{Protein
|Name=Adenylate kinase 1
|image=
|caption=
|Symbol=AK1
|AltSymbols=
|HGNCid=361
|Chromosome=9
|Arm=q
|Band=34.1
|LocusSupplementaryData=
|ECnumber=2.7.4.3
|OMIM=103000
|EntrezGene=203
|RefSeq=NM_000476
|UniProt=P00568
|PDB=
}}
'''Adenylate kinase''' (also known as '''ADK''' or '''myokinase''') is a [[phosphotransferase]] [[enzyme]] that catalyzes the interconversion of adenine nucleotides, and plays an important role in cellular energy [[homeostasis]] (see the [[Homeostasis#Biological homeostasis|"Biological homeostasis" section of "Homeostasis"]]). The reaction catalyzed is:
2 [[Adenosine diphosphate|ADP]] ⇔ [[Adenosine triphosphate|ATP]] + [[Adenosine monophosphate|AMP]]
The equilibrium constant in the direction written is 0.44. Thus, the ΔG<sup>o</sup> for this reaction is close to zero. In muscle of a variety of species of vertebrates and invertebrates, the concentration of [[Adenosine triphosphate|ATP]] is typically 7-10 times that of [[ADP]], and usually greater than 100 times that of [[AMP]] <ref>Beis I., and Newsholme E. A. (1975). The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates. Biochem J 152, 23-32.</ref>. The rate of [[oxidative phosphorylation]] is controlled by the availability of ADP. Thus, the mitochondrion attempts to keep [[Adenosine triphosphate|ATP]] levels high due to the combined action of adenylate kinase and the controls on [[oxidative phosphorylation]].
===References===
{{Reflist}}
==External links==
* {{MeshName|Adenylate+kinase}}
[[Category:Cellular respiration]]
[[Category:EC 2.7.4]]
{{transferase-stub}}
{{Kinases}}
{{Mitochondrial enzymes}}
[[ca:Mioquinasa]]
[[de:Adenylat-Kinase]]
[[es:Adenilato kinasa]]
[[he:אדנילאט קינאז]]
[[uk:Аденілаткіназа]]