Alclometasone 3493613 209315444 2008-04-30T21:15:11Z Chempedia 6903824 {{drugbox | IUPAC_name = [7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate | image = Alclometasone.png | CAS_number = 66734-13-2 | ATC_prefix = D07 | ATC_suffix = AB10 | ATC_supplemental = {{ATC|S01|BA10}} | PubChem = 636374 | DrugBank = APRD00783 | C=28 | H=37 | Cl=1 | O=7 | molecular_weight = 521.042 g/mol | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | pregnancy_category = | legal_status = | routes_of_administration = topical }} '''Alclometasone''' is synthetic [[glucocorticoid]] [[steroid]] for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.<br> '''Alclometasone Dipropionate''' marketed as medication '''Aclovate''' by [[GlaxoSmithKline]]. ==Pharmacology== '''Alclometasone''' inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. [[histamine]]). ==Indications== '''Alclometasone''' cream and onintment are indicated for the relief of corticosteroid-responsive dermatoses, including: <li>atopic [[dermatitis]] <li>[[eczema]] <li>[[psoriasis]] <li>allergic dermatitis <li>contact dermatitis <li>actinic dermatitis <li>kiss-type allergy <li>skin itch <br> '''Alclometasone''' may be used on sensetive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients. ==Contraindications== <li>hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms <li>cutaneous [[tuberculosis]] <li>chicken pox <li>perioral dermatitis <li>[[acne]] <li>[[rosacea]] <li>open wounds <li>trophic ulcers <li>viral infection of skin <li>skin manifestations of syphilis ==Side effects== '''Alclometasone''' Adverse reactions/Side effects (sometimes, less than 1-2% cases) include: <li>burning <li>itching <li>[[erythema]] <li>skin reddening <li>xerodermia <li>skin irritation <li>acne <li>hypopigmentation <li>prickly heat <li>folliculitis <li>white atrophy <li>hypertrichosis <li>reinfection of skin ==How supplied== '''Alclometasone''' as Aclovate is supplied in: <li>Cream; Topical; 0.05% <li>Ointment; Topical; 0.05% ==External links== {{Corticosteroids}} [[Category:Glucocorticoids]] [[ja:アルクロメタゾン]]