Alclometasone
3493613
209315444
2008-04-30T21:15:11Z
Chempedia
6903824
{{drugbox
| IUPAC_name = [7-chloro-11-hydroxy- 10,13,16-trimethyl-3-oxo-17- (2-propanoyloxyacetyl)- 7,8,9,11,12, 14,15,16- octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
| image = Alclometasone.png
| CAS_number = 66734-13-2
| ATC_prefix = D07
| ATC_suffix = AB10
| ATC_supplemental = {{ATC|S01|BA10}}
| PubChem = 636374
| DrugBank = APRD00783
| C=28 | H=37 | Cl=1 | O=7
| molecular_weight = 521.042 g/mol
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| pregnancy_category =
| legal_status =
| routes_of_administration = topical
}}
'''Alclometasone''' is synthetic [[glucocorticoid]] [[steroid]] for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.<br>
'''Alclometasone Dipropionate''' marketed as medication '''Aclovate''' by [[GlaxoSmithKline]].
==Pharmacology==
'''Alclometasone''' inhibits phospholipase A2 by inducing production of lipocortins;
inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid,
reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. [[histamine]]).
==Indications==
'''Alclometasone''' cream and onintment are indicated for
the relief of corticosteroid-responsive dermatoses, including:
<li>atopic [[dermatitis]]
<li>[[eczema]]
<li>[[psoriasis]]
<li>allergic dermatitis
<li>contact dermatitis
<li>actinic dermatitis
<li>kiss-type allergy
<li>skin itch
<br>
'''Alclometasone''' may be used on sensetive skin sites (face, skinfolds); in pediatric patients 1 year or
older and in geriatric patients.
==Contraindications==
<li>hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
<li>cutaneous [[tuberculosis]]
<li>chicken pox
<li>perioral dermatitis
<li>[[acne]]
<li>[[rosacea]]
<li>open wounds
<li>trophic ulcers
<li>viral infection of skin
<li>skin manifestations of syphilis
==Side effects==
'''Alclometasone''' Adverse reactions/Side effects (sometimes, less than 1-2% cases) include:
<li>burning
<li>itching
<li>[[erythema]]
<li>skin reddening
<li>xerodermia
<li>skin irritation
<li>acne
<li>hypopigmentation
<li>prickly heat
<li>folliculitis
<li>white atrophy
<li>hypertrichosis
<li>reinfection of skin
==How supplied==
'''Alclometasone''' as Aclovate is supplied in:
<li>Cream; Topical; 0.05%
<li>Ointment; Topical; 0.05%
==External links==
{{Corticosteroids}}
[[Category:Glucocorticoids]]
[[ja:アルクロメタゾン]]