Amblyopia 581459 224737721 2008-07-10T05:20:00Z CERminator 6756741 +bs {{Infobox_Disease | Name = Amblyopia | Image = | Caption = | DiseasesDB = 503 | ICD10 = {{ICD10|H|53|0|h|53}} | ICD9 = {{ICD9|368.0}} | ICDO = | OMIM = | MedlinePlus = 001014 | eMedicineSubj = oph | eMedicineTopic = 316 | MeshID = D000550 | }} '''Amblyopia''', otherwise known as lazy eye,<ref name="pmid17304868">{{cite journal |author= |title=Information from your family doctor. Amblyopia ("lazy eye") in your child |journal=American family physician |volume=75 |issue=3 |pages=368 |year=2007 |pmid=17304868 |doi=}}</ref> is a [[Disease|disorder]] of the [[visual system]] that is characterized by poor or indistinct [[Visual perception|vision]] in an eye that is otherwise physically normal, or out of proportion to associated structural abnormalities. It has been estimated to affect 1&ndash;5% of the population.<ref name="asn"> {{cite journal | url=http://www.optometrists.asn.au/gui/files/ceo886365.pdf | author=Weber, JL; Wood, Joanne | year=2005 | title=Amblyopia: Prevalence, Natural History, Functional Effects and Treatment | journal=Clinical and Experimental Optometry | volume=88 | issue=6 | pages=365–375 | format={{Dead link|date=June 2008}} &ndash; <sup>[http://scholar.google.co.uk/scholar?hl=en&lr=&q=intitle%3AAmblyopia%3A+Prevalence%2C+Natural+History%2C+Functional+Effects+and+Treatment&as_publication=Clinical+and+Experimental+Optometry&as_ylo=2005&as_yhi=2005&btnG=Search Scholar search]</sup>}} </ref> The problem is caused by either no transmission or poor transmission of the visual image to the [[brain]] for a sustained period of dysfunction or during early [[childhood]]. Amblyopia normally only affects one eye, but it is possible to be amblyopic in both eyes if both are similarly deprived of a good, clear visual image. Detecting the condition in early childhood increases the chance of successful treatment. While the colloquialism "lazy eye" is frequently used to refer to amblyopia, the term is inaccurate because there is no "laziness" of either the eye or the amblyope involved in the condition. Therefore, some consider the term "lazy eye" to be [[pejorative]]. ==Physiology== Amblyopia is a developmental problem in the brain, not an organic problem in the eye (although organic problems can induce amblyopia which persist after the organic problem has resolved).<ref name="Mckee"> {{cite journal | author=McKee, SP., Levi, DM., Movshon, JA. | year=2003 | title=The pattern of visual deficits in amblyopia | journal=J Vision | volume=3 | issue=5 | pages=380–405 | url=http://journalofvision.org/3/5/5/McKee-2003-jov-3-5-5.pdf | doi=10.1167/3.5.5 }} </ref> The part of the brain corresponding to the visual system from the affected eye is not stimulated properly, and develops abnormally. This has been confirmed via direct brain examination. [[David H. Hubel]] and [[Torsten Wiesel]] won the [[Nobel Prize in Physiology or Medicine]] in 1981 for their work demonstrating the irreversible damage to [[ocular dominance columns]] produced in kittens by sufficient visual deprivation during the so-called "critical period". The maximum critical period in humans is from birth to two years old.<ref name=Cooper>{{cite web | url=http://www.strabismus.org/detection_diagnosis.html | title=All About Strabismus | author= Jeffrey Cooper & Rachel Cooper | publisher=Optometrists Network | accessdate=2008-03-09}}</ref> ==Symptoms== Many people with amblyopia, especially those who are only mildly so, are not even aware they have the condition until tested at older ages, since the vision in their stronger eye is normal. However, people who have ''severe'' amblyopia may experience associated visual disorders, most notably poor [[depth perception]]. Amblyopes may suffer from poor spatial [[Visual acuity|acuity]], low sensitivity to [[contrast (vision)|contrast]] and some "higher-level" deficits to vision such as reduced sensitivity to [[Motion perception|motion]].<ref name="Hess"> {{cite journal | author=Hess, R.F., Mansouri, B., Dakin, S.C., & Allen, H.A. | year=2006 | title=Integration of local motion is normal in amblyopia | journal=J Opt Soc Am A Opt Image Sci Vis | volume=23 | issue=5 | pages=986–992 | doi=10.1364/JOSAA.23.000986 }} </ref> These deficits are usually specific to the amblyopic eye, not the unaffected "fellow" eye. Amblyopes also suffer from problems of binocular vision such as limited stereoscopic depth perception and usually have difficulty seeing the three-dimensional images in hidden stereoscopic displays such as [[autostereogram]]s.<ref name="Tyler"> {{cite journal | author=Tyler, C.W. | year=2004 | title= Binocular Vision In, Duane's Foundations of Clinical Ophthalmology. Vol. 2, Tasman W., Jaeger E.A. (Eds.), J.B. Lippincott Co.: Philadelphia}} </ref> However perception of depth from monocular cues such as size, perspective, and motion parallax is normal. ==Types== Amblyopia can be caused by [[deprivation]] of vision early in life, by [[strabismus]] (misaligned eyes), by vision-obstructing disorders, or by [[anisometropia]] (different degrees of [[myopia]] or [[hyperopia]] in each eye). ===Strabismic amblyopia=== {{Main|Strabismus}} [[Image:Child eyepatch.jpg|right|thumb|A child wearing an adhesive eyepatch to correct amblyopia]] [[Strabismus]], sometimes erroneously also called ''lazy eye'', is a condition in which the eyes are misaligned in a variety of different ways. Strabismus usually results in normal vision in the preferred sighting eye, but may cause abnormal vision in the deviating or strabismic eye due to the discrepancy between the images projecting to the brain from the two eyes.<ref name="Levi">{{cite journal | author=Levi, D.M. | year=2006 | title=Visual processing in amblyopia: human studies | journal=Strabismus | volume=14 | issue=1 | pages=11–19| doi=10.1080/09273970500536243 }}</ref> Adult-onset strabismus usually causes double vision ([[diplopia]]), since the two eyes are not fixated on the same object. Children's brains, however, are more [[Neuroplasticity|neuroplastic]], and therefore can more easily adapt by [[Suppression (eye)|suppressing images]] from one of the eyes, eliminating the double vision. This plastic response of the brain, however, interrupts the brain's normal development, resulting in the amblyopia. Strabismic amblyopia is treated by clarifying the visual image with glasses, and/or encouraging use of the amblyopic eye with a [[eyepatch]] over the dominant eye or [[Atropine#Ophthalmic_use|pharmacologic penalization]] of it (usually by applying [[atropine]] drops to temporarily paralyze the muscles and weaken vision in the good eye&mdash;this helps to prevent the bullying and teasing associated with wearing a patch). The ocular alignment itself may be treated with surgical or non-surgical methods, depending on the type and severity of the [[strabismus]].<ref name="Holmes">{{cite journal | author=Holmes, Repka, Kraker & Clarke | year=2006 | title=The treatment of amblyopia | journal=Strabismus | volume=14 | issue=1 | pages=37–42| doi=10.1080/09273970500536227 }}</ref> ===Refractive or anisometropic amblyopia=== Refractive amblyopia may result from [[anisometropia]] (unequal refractive errors between the two eyes). Anisometropia exists when there is a difference in the [[refraction]] between the two eyes. The eye with less far-sighted (hyperopic) refractive error provides the brain with a clearer image, and is favored by the brain. Refractive amblyopia is usually less severe than strabismic amblyopia and is commonly missed by [[primary care physician]]s because of its less dramatic appearance and lack of obvious physical manifestation, such as with strabismus.<ref>[http://www.aafp.org/afp/20010815/623.html Commonly Missed Diagnoses in the Childhood Eye Examination - August 15, 2001 - American Family Physician<!-- Bot generated title -->]</ref> Frequently, amblyopia is associated with a combination of anisometropia and strabismus. Pure refractive amblyopia is treated by correcting the refractive error early with prescription lenses. [[Vision therapy]] and/or [[eyepatch|eye patching]] can also be used to develop and/or improve visual abilities, binocular vision, depth perception, etc. '''Meridional amblyopia''' is a mild condition in which lines are seen less clearly at some orientations than others after full refractive correction. An individual who had an [[astigmatism (eye)|astigmatism]] at a young age that was not corrected by glasses will later have astigmatism that cannot be optically corrected. {{Fact|date=April 2007}} ===Form-deprivation and occlusion amblyopia=== Form-deprivation amblyopia (''Amblyopia ex anopsia'') results when the ocular media become [[Opacity (optics)|opaque]], such as is the case with [[cataract]]s or [[cornea]]l scarring from [[forceps]] injuries during birth.<ref>[http://archopht.ama-assn.org/cgi/content/abstract/99/12/2137 Arch Ophthalmol - Abstract: Visual prognosis in patients with ruptures in Descemet's membrane due to forceps injuries, December 1981, Angell et al. 99 (12): 2137<!-- Bot generated title -->]</ref> These opacities prevent adequate sensory input from reaching the eye, and therefore disrupt visual development. If not treated in a timely fashion, amblyopia may persist even after the cause of the opacity is removed. Sometimes, drooping of the [[eyelid]] ([[ptosis (eyelid)|ptosis]]) or some other problem causes the upper eyelid to physically occlude a child's vision, which may cause amblyopia quickly. Occlusion amblyopia may be a complication of a [[hemangioma]] that blocks some or all of the eye. ==Treatment and prognosis== Treatment of ''strabismic'' or ''anisometropic amblyopia'' consists of correcting the optical deficit and forcing use of the amblyopic eye, either by [[eye patch|patching]] the good eye, or by instilling [[topical]] [[atropine]] in the eye with better vision. One should also be wary of over-patching or over-penalizing the good eye when treating for amblyopia, as this can create so-called "reverse amblyopia" in the other eye.<ref name="Holmes"/><ref>[http://www.nei.nih.gov/health/amblyopia/index.asp Amblyopia [NEI Health Information&#93;<!-- Bot generated title -->]</ref> ''Form deprivation amblyopia'' is treated by removing the opacity as soon as possible followed by patching or penalizing the good eye to encourage use of the amblyopic eye.<ref name="Holmes"/> Although the best outcome is achieved if treatment is started before age 5, research has shown that children older than age 10 and some adults can show improvement in the affected eye. Children from 7 to 12 who wore an eye patch and performed near point activities ([[vision therapy]]) were four times as likely to show a two line improvement on a standard 11 line [[Snellen chart|eye chart]] than amblyopic children who did not receive treatment. Children 13 to 17 showed improvement as well, albeit in smaller amounts than younger children. (NEI-funded Pediatric Eye Disease Investigator Group, 2005)<ref name="Holmes"/><ref name="PEDIG">{{cite journal | author=Pediatric Eye Disease Investigator Group | title=Randomized trial of treatment of amblyopia in children aged 7 to 17 years | journal=Archives of Ophthalmology | volume=123 | issue=April | year=2005 | pages=437–447 | doi= 10.1001/archopht.123.4.437 | pmid=15824215}} </ref> == See also == * [[Convergence insufficiency]] * [[Diplopia]] * [[Orthoptics]] * [[Stereoblindness]] ==References== {{reflist}} ==External links== ===Organizations=== *[http://www.nei.nih.gov/health/amblyopia/index.asp National Eye Institute (NEI)] Resource Guide *[http://www.lazyeyesite.org/ Lazy Eye Site] from the [[National Health Service]], [[UK]] *[http://www.aapos.org/displaycommon.cfm?an=1&subarticlenbr=63 The American Association for Pediatric Ophthalmology and Strabismus] (AAPOS). *[http://www.afakids.com The Amblyopia Foundation of America] ===Information=== *[http://www.emedicine.com/oph/topic316.htm eMedicine] - Amblyopia. *[http://www.lazyeye.org Optometrists Network] - All About Amblyopia. *[http://www.convergenceinsufficiency.org Convergence Insufficiency] - a common visual condition confused with Lazy Eye. *[http://www.preventblindness.org/children/amblyopiaFAQ.html Prevent Blindness America] - Amblyopia FAQ *[http://www.surgery-sugery.com/Lazy-Eye-Surgery.php Video with optometrist showing the options for fixing lazy eye] ===News=== *[http://www.iht.com/articles/2006/01/04/healthscience/snvital.php IHT article on treating amblyopia in patients who are in their late teens or older] *[http://news.bbc.co.uk/1/hi/health/4436439.stm BBC article on new study that finds lazy eye can be treated in teen years] *[http://www.nei.nih.gov/news/pressreleases/041105.asp U.S. National Institutes of Health - Older Children Can Benefit from Treatment] *[http://www.nature.com/eye/journal/v20/n3/abs/6701882a.html Treatment using VR software being trialed (Eastgate, et.al. Nottingham University)] *[http://www.virart.nott.ac.uk/ibit/ Interactive Binocular Treatment for Amblyopia] {{Eye pathology}} [[Category:Ophthalmology]] [[Category:Vision]] [[bs:Ambliopija]] [[ca:Ambliopia]] [[de:Amblyopie]] [[es:Ambliopía]] [[fr:Amblyopie]] [[is:Latt auga]] [[it:Ambliopia]] [[he:עין עצלה]] [[nl:Amblyopie]] [[ja:弱視]] [[pl:Amblyopia]] [[pt:Ambliopia]] [[ru:Амблиопия]] [[sr:Амблиопија]] [[zh:弱視]]