Amidrine 2132969 188360048 2008-02-01T11:29:55Z DiamonDie 198549 fixed unnecessary capitalization, some wikifying '''Amidrine''', '''Duradrin''' or '''Midrin''', is a combination of [[acetaminophen]], [[dichloralphenazone]], and [[isometheptene]] used mostly to treat [[headache]]s. ==Description== Acetaminophen (paracetamol) is a common over-the-counter pain reliever and [[fever]] reducer. Dichloralphenazone is a mild [[sedative]] owing primarily to its hydrolysis product, [[chloral hydrate|chloral hydrate]]. Chloral hydrate, a schedule C-IV controlled substance, is a [[sedative]]/[[hypnotic]] drug that acts on the central nervous system to produce relaxation and decrease emotional stimuli that influence the perception of pain associated with headache. Isometheptene is a [[vasoconstriction|vasoconstrictor]], a drug that causes constriction (narrowing) of cerebral blood vessels. The pathophysiology of vascular headaches, especially [[migraine]], is thought to be related to dilation of these cerebral blood vessels, so drugs that act to constrict them are used in the treatment of these problems. ==Common application== This drug is commonly used in the treatment of [[migraine]] headaches and is currently available in the United States and United Kingdom by prescription only. {{Pharma-stub}} [[Category:Antimigraine drugs]]