Aschoff body
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2008-05-26T01:43:35Z
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{{Cleanup|date=February 2008}}
[[Image:Aschoff Body in Rheumatic Myocarditis.jpg|thumb|Aschoff body in Rheumatic [[Myocarditis]] ]]
'''Aschoff bodies''' or '''Aschoff nodules''' are painless [[Nodule (medicine)|nodules]] present in [[rheumatic fever]]. It is an area of focal interstitial myocardial inflammation. Fully developed Aschoff bodies consist of fibrinoid change in [[connective tissue]], [[lymphocyte]]s, occasional [[plasma cell]]s, and abnormal characteristic [[histiocyte]]s. They are Aschoff cell [[granulomas]] with a fibrinoid [[necrosis|necrotic]] centre found in the [[myocardium]] surrounding [[blood vessel]]s, and other regions of the body. [[Myocyte]]s in the myocardium can merge with the Aschoff cells to form giant cells of Aschoff, In addition, there are [[leukocytes]], [[lymphocytes]], [[eosinophils]] and [[plasma cells]] and Anitschkow myocytes. The Aschoff bodies were discovered independently by the German pathologist [[Ludwig Aschoff]] 1904 and one year later by [[Paul Rudolf Geipel]].
Image link: http://erl.pathology.iupui.edu/C603/GENE426.HTM
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[[Category:Histopathology]]
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