Bafilomycin (BAF)
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2008-06-30T07:23:45Z
AbuAmir
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baf b1 osteoporosis
'''Bafilomycin''' is indeed a whole family of toxic [[macrolide]] [[antibiotics|antibiotic]] derived from [[Streptomyces]] griseus. These compounds all appear in the same [[fermentation]] and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. ([[V-ATPase]]).
The most used Bafilomycin is Bafilomycin A1. This is a useful tool as it can prevent the re-acidification of [[synaptic]] vesicles once they have undergone exocytosis.
Bafilomycin has [[antibacterial]], [[antifungal]], [[antineoplastic]], [[immunosuppressive]] activities. It has been shown to decrease multi-drug resistance.
Bafilomycin B1 has been mentioned as a potential [[osteoporosis|antiosteoporotic agent]] in treating bone lytic diseases
'''Bafilomycin A1 data'''<ref>Source (with permission) [http://www.fermentek.co.il/bafilomycin_A1.htm Bafilomycin A1 product page] from [[Fermentek]]</ref>
# CAS number: 88899-55-2
# Molecular Formula: C35H58O9
# Appearance: Yellow powder
# Molecular weight: 622.830
== References ==
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{{Cell-biology-stub}}
[[Category:Neurophysiology]]
[[Category:Antibiotics]]
[[Category:Biomolecules]]