Bafilomycin (BAF) 4128733 222613135 2008-06-30T07:23:45Z AbuAmir 826705 baf b1 osteoporosis '''Bafilomycin''' is indeed a whole family of toxic [[macrolide]] [[antibiotics|antibiotic]] derived from [[Streptomyces]] griseus. These compounds all appear in the same [[fermentation]] and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. ([[V-ATPase]]). The most used Bafilomycin is Bafilomycin A1. This is a useful tool as it can prevent the re-acidification of [[synaptic]] vesicles once they have undergone exocytosis. Bafilomycin has [[antibacterial]], [[antifungal]], [[antineoplastic]], [[immunosuppressive]] activities. It has been shown to decrease multi-drug resistance. Bafilomycin B1 has been mentioned as a potential [[osteoporosis|antiosteoporotic agent]] in treating bone lytic diseases '''Bafilomycin A1 data'''<ref>Source (with permission) [http://www.fermentek.co.il/bafilomycin_A1.htm Bafilomycin A1 product page] from [[Fermentek]]</ref> # CAS number: 88899-55-2 # Molecular Formula: C35H58O9 # Appearance: Yellow powder # Molecular weight: 622.830 == References == {{reflist}} {{Cell-biology-stub}} [[Category:Neurophysiology]] [[Category:Antibiotics]] [[Category:Biomolecules]]