Balsalazide 5138213 215570349 2008-05-28T19:59:52Z ChemNerd 2246483 Quick-adding category "Benzoic acids" (using [[WP:HOTCAT|HotCat]]) {{drugbox | IUPAC_name = 5-[4-(2-carboxyethylcarbamoyl)phenyl]diazenyl-2-hydroxy-benzoic acid | image = Balsalazide.png | CAS_number = 80573-04-2 | ATC_prefix = A07 | ATC_suffix = EC04 | ATC_supplemental = | PubChem = 5362070 | DrugBank = APRD00141 | C=17 | H=15 | N=3 | O=6 | molecular_weight = 357.318 g/mol | bioavailability = <1% | protein_bound = ≥99% | metabolism = | elimination_half-life = 12hr | pregnancy_US = B | pregnancy_category = | legal_status = POM [UK] | routes_of_administration = }} '''Balsalazide''' is an anti-inflammatory drug used in the treatment of [[Inflammatory Bowel Disease]]. It is sold under the name "Colazal" in the US and "Colazide" in the UK. It is also sold in generic form in the US by several generic manufacturers. The chemical name is (E)-5-[[-4-[[(2-carboxyethyl) amino]]carbonyl] phenyl]azo] -2-hydroxybenzoic acid. It is usually administered as the disodium salt. Balsalazide releases [[mesalazine]], also known as 5-aminosalicylic acid, or 5-ASA, in the large intestine. Its advantage over that drug in the treatment of [[Ulcerative colitis]] is believed to be the delivery of the active agent past the small intestine to the large intestine, the active site of ulcerative colitis. ==External links== *[http://www.fda.gov/cder/consumerinfo/druginfo/colazal.HTM FDA Colazal Info] *[http://www.fda.gov/cder/foi/label/2000/20610lbl.pdf Colazal Label (PDF)] {{Antidiarrheals, intestinal anti-inflammatory/anti-infective agents}} [[Category:Gastroenterology]] [[Category:Azo compounds]] [[Category:Benzoic acids]]