Bentiromide 5280980 225378194 2008-07-13T10:51:46Z JaGa 2092487 add SVG image, ref {{chembox new | ImageFile=Bentiromide.svg | ImageSize=150px | IUPACName=<small>4-[2-benzamido-3- (4-hydroxyphenyl)- propanoyl] aminobenzoic acid</small> | OtherNames=<small>(S)-4-((2-(benzoylamino)-3-(4-hydroxyphenyl) -1-oxopropyl)amino)benzoic acid<br />(S)-p-(α-benzamido-p-hydroxyhydrocinnamamido) benzoic acid<br />BRN 2910938<br />Benzoyltyrosyl-p-aminobenzoic acid (Btpaba)<br />C12779<br />CHEMBANK2959<br />Chymex<br />D01346<br />N-benzoyl-L-tyrosyl-p-aminobenzoic acid<br />P-((N-benzoyl-L-tyrosin)amido)benzoic acid<br />PFD<br />PFT<br />Ro 11-7891</small> | Reference=<ref>[http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2329&loc=ec_rcs Bentiromide - Compound Summary], [[PubChem]].</ref> | Section1={{Chembox Identifiers | EINECS=253-349-8 | PubChem=2329 | Abbreviations=Btpaba | CASNo=37106-97-1 | SMILES={{SMILES|S=C1=CC=C(C=C1)C(=O)NC(CC2=CC=C(C=C2)O) C(=O)NC3=CC=C(C=C3)C(=O)O}} | InChI=1/C23H20N2O5/c26-19-12-6-15(7-13-19)14-20 (25-21(27)16-4-2-1-3-5-16)22(28)24-18-10-8-17 (9-11-18)23(29)30/h1-13,20,26H,14H2,(H,24,28) (H,25,27)(H,29,30)/f/h24-25,29H}} | Section2={{Chembox Properties | Formula=C<sub>23</sub>H<sub>20</sub>N<sub>2</sub>O<sub>5</sub> | MolarMass=404.4153 | Density= | Solubility= | SolubleOther= | Solvent= | MeltingPt= | BoilingPt= | pKa= | pKb= | IsoelectricPt= | SpecRotation= | RefractIndex= | Viscosity= | Dipole=}} | Section3={{Chembox Structure | CrystalStruct= | Coordination= | MolShape= | Dipole=}} | Section4={{Chembox Thermochemistry | DeltaHf= | DeltaHc= | Entropy= | HeatCapacity=}} | Section5={{Chembox Pharmacology | ATCCode=V04CK03 | DrugBank=APRD00818 | Bioavail= | Metabolism= | HalfLife= | Excretion= | PregCat= | AdminRoutes=}} | Section6={{Chembox Explosive | ShockSens= | FrictionSens= | ExplosiveV= | REFactor=}} | Section7={{Chembox Hazards | EUClass= | MainHazards= | NFPA-H= | NFPA-F= | NFPA-R= | NFPA-O= | RPhrases= | SPhrases= | RSPhrases= | FlashPt= | Autoignition= | ExploLimits= | PEL= | RTECS=}} | Section9={{Chembox Related | OtherAnions= | OtherCations= | OtherFunctn= | Function= | OtherCpds=}} }} '''Bentiromide''' is a [[peptide]] used as a screening test for [[exocrine]] [[pancreatic]] insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of [[p-aminobenzoic acid|4-aminobenzoic acid]] and its [[metabolites]] excreted in the urine is taken as a measure of the [[chymotrypsin]]-secreting activity of the pancreas. Headache and gastrointestinal disturbances have been reported in patients taking bentiromide. Bentiromide is not available in the [[U.S.]] or [[Canada]] (It was withdrawn in the US in October 1996.) ==Data== *XLogP=3.201 *tautomers=12 *H_bond_donor=4 *H_bond_acceptor=5 == See also == * [[chronic pancreatitis]] * [[ATC_code_V04#V04CK_Tests_for_pancreatic_function]] ==References== {{reflist}} {{pharma-stub}} [[Category:Benzoic acids]]