Benzamide
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2008-06-05T16:15:17Z
タチコマ robot
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robot Adding: [[pl:Benzamid]]
{{Chembox new
| ImageFile = Benzamide.png
| ImageSize =
| IUPACName = Benzamide
| OtherNames = Benzoic acid amide, Phenyl carboxamide, Benzoylamide
| Section1 = {{Chembox Identifiers
| CASNo = 55-21-0
| EINECS = 200-227-7
| PubChem = 2331
| SMILES = C1=CC=C(C=C1)C(=O)N
| InChI = 1/C7H7NO/c8-7(9)6-4-2-1- 3-5-6/h1-5H,(H2,8,9)/f/h8H2
| RTECS = CU8700000
}}
| Section2 = {{Chembox Properties
| Formula = C<sub>7</sub>H<sub>7</sub>NO
| MolarMass = 121.14 g/mol
| Appearance = Off-white solid
| Density = 1.341 g/cm<sup>3</sup>
| MeltingPt = 127 - 130 °C
| BoilingPt = 288 °C
| Solubility = 13 g/l
pKa in DMSO = 23.35
}}
| Section3 = {{Chembox Hazards
| EUClass = Harmful ('''Xn''')
| MainHazards =
| FlashPt = 180 °C
| Autoignition = > 500 °C
| NFPA-H = 1
| NFPA-F = 1
| NFPA-R = 0
| NFPA-O =
| RPhrases = {{R22}}, {{R40}}
| SPhrases = {{S36/37/39}}
}}
}}
'''Benzamide''' is an off-white solid with the chemical formula of C<sub>6</sub>H<sub>5</sub>CONH<sub>2</sub>. It is a derivative of [[benzoic acid]]. It is slightly soluble in water, and soluble in many organic solvents.
==Benzamides==
[[Image:Amisulpride2d.svg|thumb|left|[[Amisulpride]] - a substituted benzamide]]
Benzamides are a class of amides of benzoic acid. In [[psychiatry]] some substituted benzamides are therapeutically used as [[neuroleptics]] and/or [[antipsychotics]]. Two active substances from the group of benzamides are in use:
* [[Sulpiride]]
* [[Amisulpride]]
Another benzamide, [[Remoxipride]], was taken off the market in 1993 because of life-threatening [[adverse drug reaction|side effects]]. Some [[analgetic]]s like [[salicylamide]] or [[ethenzamide]] also have benzamide structures.
==See also==
* [[ATC code N05#N05AL Benzamides]]
==External links==
* [http://www.chemicalland21.com/industrialchem/organic/BENZAMIDE.htm Physical characteristics]
* [http://physchem.ox.ac.uk/MSDS/BE/benzamide.html Safety MSDS data]
* {{GPnotebook|1309016066}}
[[Category:Amines]]
[[Category:Aromatic amines]]
{{amine-stub}}
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