Benzphetamine
276249
224021161
2008-07-06T23:34:53Z
68.45.219.63
/* Controlled substance classification */
{{drugbox
| IUPAC_name = N-benzyl-N-methyl-1-phenyl-propan-2-amine
| image =
| width = 151
| CAS_number = 156-08-1
| ATC_prefix =
| ATC_suffix =
| ATC_supplemental =
| PubChem = 2341
| DrugBank = APRD00759
| C=17 | H=21 | N=1
| molecular_weight = 239.355 g/mol
| bioavailability =
| protein_bound = 75-99%
| metabolism =
| elimination_half-life =
| pregnancy_category =
| legal_US = Schedule III
| legal_status =
| routes_of_administration =
}}
'''Benzphetamine''' (brand name: '''Didrex''') is an anti-obesity drug marketed under this brand in the [[United States|USA]] by [[Pharmacia]]. Benzphetamine is used as a short term adjunct in management of [[exogenous]] obesity. It is closely related to [[amphetamine]].
[[Image:Benzphetamine.jpg|frame|left]]
==Pharmacology==
Benzphetamine is a [[sympathomimetic]] [[amine]], and is classified as an anorectic. The main function of this drug is to reduce hunger, which in turn reduces caloric intake.
Although the mechanism of action of the sympathomimetic appetite suppressants in the treatment of obesity is not fully known, these medications have pharmacological effects similar to those of amphetamines. Amphetamine and related sympathomimetic medications (such as benzphetamine) are thought to stimulate the release of norepinephrine and/or dopamine from storage sites in nerve terminals in the lateral hypothalamic feeding center, thereby producing a decrease in appetite. This release is mediated by the binding of benzphetamine to centrally located adrenergic receptors. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.
==Contraindications==
Benzphetamine is contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyper-thyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma. Benzphetamine should not be given to patients who are in an agitated state or who have a history of drug abuse.
==Controlled substance classification==
Benzphetamine is unique in its classification as a [[Schedule III]] drug in the United States. (Most members of the amphetamine family are classified in the more highly-regulated [[Schedule II]].) It's notable that benzphetamine is metabolized by the human body into amphetamine and [[methamphetamine]] metabolites, making it one of the very few drugs to undergo [[in vivo]] conversion to a substance of higher addiction and abuse potential. Benzphetamine itself does not have a such a high recreational abuse potential ([[Controlled Substances Act|Schedule III]]) because any administration route (ingested, insufflated, injected, etc.) would still have a sustained release due to the amount of time it would take the liver to metabolize it into [[amphetamine]] and [[methamphetamine]].
{{Stimulants}}
[[Category:Amphetamines]]
[[Category:Anorectics]]
[[es:Benzfetamina]]
[[gl:Benzfetamina]]
[[pl:Benzfetamina]]