Bisphosphoglycerate mutase 5712665 216178323 2008-05-31T12:55:25Z DOI bot 6652755 Citation maintenance. You can [[WP:DOI|use this bot]] yourself! Please [[User:DOI_bot/bugs|report any bugs]]. {{Protbox |Name=2,3-bisphosphoglycerate mutase |Photo=Phosphoglycerate mutase 3PGM wpmp.png |Caption={{{!}} align="center" border="0" {{!}} '''Enzyme''' {{!}} Phosphoglycerate mutase {{!}}- {{!}} '''PDB Code''' {{!}} {{PDB|3PGM}} {{!}}- {{!}} '''Organism''' {{!}} [[Yeast]] {{!}}} | HGNCid = 1093 | Symbol = BPGM |AltSymbols = | Chromosome = 7 | Arm = q | Band = 31 | LocusSupplementaryData = -q34 |Gene= |Gene_type= |Protein_length= |Molecular_weight= |Structure= |Type= |Functions= |Domains= |Motifs= |Alternative_products= |Catalytic_activity= |Cofactors= |Enzyme_regulation= |km= |Vmax= |Biophysicochemical_properties= |Diseases= |Pharmaceuticals= |Biotechnology= |Taxa= |Cells= |Location= |Mods= |Names= |Pathways= |Interactions= |Actions= |Agonists= |Antagonists= |Accession_numbers= | EntrezGene = 669 | OMIM = 222800 | RefSeq = NM_001724 | UniProt = P07738 |PDB = | ECnumber = 5.4.2.4 |Codes= |Review= |Pages= }} '''Bisphosphoglycerate mutase''' (BPGM) catalyzes the conversion of [[1,3-bisphosphoglycerate]] (1,3-BPG) to [[2,3-bisphosphoglycerate]] (2,3-BPG). This enzyme should not be confused with [[Phosphoglycerate mutase]] (PGM) which plays a major role in [[glycolysis]]. While 1,3-BPG is an important [[intermediate]] in [[Glycolysis]], 2,3-BPG is not. 2,3-BPG does have an important role in [[erythrocytes]], acting as an [[allosteric regulation|allosteric inhibitor]] of [[hemoglobin]]. The binding of 2,3-BPG decreases hemoglobin's affinity for oxygen and facilitates the transfer of O<sub>2</sub> to tissues. BPGM plays an important role in erythrocytes, diverting up to 20% of the total [[metabolic flux|glycolytic flux]] in order to maintain concentrations of 2,3-BPG that are roughly equal to concentrations of hemoglobin. Excess amounts of 2,3-BPG can re-enter the glycolytic pathway through a [[phosphatase]] catalyzed conversion to [[glycerate 3-phosphate]] (G3P). This two-step process parallels Step 7 of main glycolytic pathway in which 1,3-BPG is converted directly to G3P with the [[Substrate-level phosphorylation|phosphorylation]] of [[Adenosine diphosphate|ADP]] to form [[Adenosine triphosphate|ATP]]. The two-step BPGM/phosphatase pathway doesn't generate ATP and is therefore an inefficient way to arrive at G3P. ==External links== * {{cite journal |author=Fujita T et al |title=Human erythrocyte bisphosphoglycerate mutase: inactivation by glycation in vivo and in vitro |journal=J Biochem (Tokyo) |volume=124 |issue=6 |pages=1237–44 |year=1998 |pmid=9832630 |url=http://jb.oxfordjournals.org/cgi/content/abstract/124/6/1237 }} * {{MeshName|Bisphosphoglycerate+mutase}} {{Mutases}} {{Glycolysis enzymes}} {{isomerase-stub}} {{metabolism-stub}} [[it:Bisfosfoglicerato mutasi]]