Brain death 187262 223660382 2008-07-05T03:36:38Z 24.23.122.233 /* Legal history */ '''Brain death''' is a legal definition of death that emerged in the 1960s as a response to the ability to resuscitate individuals and mechanically keep the heart and lungs working. In simple terms, brain death is the irreversible end of all [[brain activity]] (including involuntary activity necessary to sustain life) due to total [[necrosis]] of the cerebral [[neurons]] following loss of [[blood flow]] and [[oxygenation]]. It should not be confused with a [[persistent vegetative state]]. ==Legal history== Traditionally, both the legal and medical communities determined [[death]] through the end of certain [[body|bodily]] functions, especially [[Respiration (physiology)|respiration]] and [[Heart rate|heartbeat]]. With the increasing ability of the medical community to resuscitate people with no heart beat, respiration or other signs of life, the need for a better definition of death became obvious. This need gained greater urgency with the widespread use of [[life support]] equipment, which can maintain body functions indefinitely, as well as rising capabilities and demand for [[organ transplantation]]. In the U.S., an ''ad hoc'' committee at [[Harvard Medical School]] published a pivotal 1968 report to define irreversible [[coma]]. The Harvard criteria gradually gained consensus toward what is now known as brain death. In the wake of the 1976 [[Karen Ann Quinlan]] controversy, state legislatures moved to accept brain death as an acceptable indication of death. Finally, a presidential commission issued a landmark 1981 report — [http://www.bioethics.gov/reports/past_commissions/defining_death.pdf ''Defin­ing Death: Medical, Legal, and Ethical Issues in the Determination of Death.''] — that rejected the "higher brain" approach to death in favor of a "whole brain" definition. This report was the basis for the [[Uniform Determination of Death Act]], which is now the law in almost all fifty states. Today, both the legal and medical communities use "brain death" as a legal definition of death. Using brain-death criteria, the medical community can declare a person legally dead even if life support equipment keeps the body's metabolic processes working. The first nation to adopt brain death as a legal definition of death was [[Finland]] in 1971. In the [[United States]], [[Kansas]] enacted a similar law earlier.<ref>{{cite journal | author=(Randell T. | title=Medical and legal considerations of brain death | journal=Acta Anaesthesiologica Scandinavica | volume=48 | issue=2 | year=2004 | pages=139–144 | pmid=14995934 | doi=10.1111/j.0001-5172.2004.00304.x}}</ref> ===Religion=== Despite the adoption of whole brain criteria in the United States and "brainstem" criteria in the United Kingdom, there has been opposition to brain death criteria from the beginning. Traditionalist [[Orthodox]] Jews have staunchly defended the traditional conception of death in the U.S. and Israel.<ref name="Bleich">{{cite book | last = Bleich | first = J. David | authorlink = J. David Bleich | title = Time of death in Jewish law | publisher = Z. Berman | date = 1991}}</ref> Conversely, some modern Orthodox rabbis and Israel's [[Chief Rabbinate of Israel|Chief Rabbinate]] have adopted determinations of death based on brain function.<ref name="Tendler">See [[Moshe Tendler]]'s elucidation of Rabbi [[Moshe Feinstein]]'s [[responsa]]</ref> As a result, Orthodox [[Jewish ethics]] has been sharply divided over key death-related policies. Tactically, Orthodox Jewish opponents to brain death have requested waivers from state law, as a matter of religious freedom, so as to continue relying on traditional indicia.<ref name="Bleich" /><ref name="Tendler" /> Meanwhile, proponents such as [http://www.hods.org Halichic Organic Donor Society] have been active in advocating [[organ donations]] and transplants. Similarly, Islamic views on brain death are mixed.<ref>{{cite journal | title = Views of Muslim scholars on organ donation and brain death | journal = Transplantation Proceedings | volume = 29 | issue = 8 | pages = 3217 | date = December 1997 | doi = 10.1016/S0041-1345(97)00876-2 | author = Al-Mousawi, M}}</ref><ref>{{cite journal | last = Khan | first = Faroque | title = The Definition of Death in Islam: Can Brain Death Be Used as A Criteria of Death in Islam? | journal = Fordham Urban Law Journal | volume = 30 | date = 2002 | accessdate = 2008-05-03}}</ref><ref>{{cite book | last = Moazam | first = Farhat | title = Bioethics and Organ Transplantation in a Muslim Society: A Study in Culture, Ethnography, and Religion | publisher = Indiana University Press | date = September 2006 | pages = 32ff | isbn = 978-0253347824}}</ref> The 1981 federal report, ''Defin­ing Death'', found that [[Catholic]] and [[Protestant]] theologies did not object to brain death criteria. Indeed, Dennis Horan, president of the [[pro-life]] group American Citizens United for Life, stated: <blockquote>Legislation limiting the concept of brain death to the irreversible cessation of total function of the brain, including the brain stem, is beneficial and does not undermine any of the values we seek to support.</blockquote> More recently, the findings of the 1981 President's Commission Report have been questioned.<ref>{{cite book | last = Potts | first = M | last2 = Byrne | first2 = PA | last3 = Nilges | first3 = RG | title = Beyond Brain Death: The Case Against Brain-Based Criteria for Human Death | publisher = Kluwer Academic Publishers | date = September 2000 | location = Dordrecht, The Netherlands | isbn = 0306468824}}</ref> The new attack on brain death criteria has been multi-pronged. First, the view that brain death marks the end of the integrated unity of the human organism has been questioned. Alan Shewmon has argued that the body as a whole is the central integrator of the organism rather than the brain.<ref>{{cite journal | last = Shewmon | first = D. Alan | title = Chronic 'brain death': Meta-analysis and conceptual consequences | journal = Neurology | volume = 51 | pages = 1538–1545 | date = 1998 | url = http://www.neurology.org/cgi/content/abstract/51/6/1538 | accessdate = 2008-05-03 | pmid = 9855499}}</ref> He appeals to, among other reasons, brain dead pregnant women who have lived up to 200+ days and given birth to healthy children, as well as to a brain dead boy who lived over fourteen years on a ventilator and with basic nursing support. Others have argued that there is insufficient evidence that the entire brain is dead in a brain dead individual.<ref name="Vitae">de Mattei, R., ed. Finis Vitae: Is Brain Death Still Life? 2006, Consiglio Nazionale delle Rescherche, Rome.</ref> Some brain dead individuals have continuing [[electroencephalogram|EEG]] activity<ref>{{cite journal | last = Young | first = Bryan | last2 = Shemie | first2 = Sam | last3 = Doig | first3 = Christopher | last4 = Teitelbaum | first4 = Jeannie | title = Brief review: The role of ancillary tests in the neurological determination of death | journal = Canadian Journal of Anesthesia | volume = 53 | pages = 620–627 | date = 2006 | url = http://www.cja-jca.org/cgi/content/abstract/53/6/620 | accessdate = 2008-05-03 | pmid = 16738299}}</ref> and others maintain normal or near-normal body temperature, implying continuing hypothalamic function.<ref>{{cite journal | last = Shewmon | first = D. Alan | title = The Brain and Somatic Integration: Insights Into the Standard Biological Rationale for Equating Brain Death With Death | journal = The Journal of Medicine and Philosophy | volume = 26 | issue = 5 | pages = 457–478 | publisher = Routledge, part of the Taylor & Francis Group | date = October 2001 | url = | doi = 10.1076/jmep.26.5.457.3000 | accessdate = 2008-05-03}}</ref> In [[Catholic medical ethics]], Pope Pius XII stated that death is determined by medical experts and it "does not fall within the competence of the Church."<ref>"The Prolongation of Life" in ''The Pope Speaks'' 4:4 1958</ref> Advocates of brain death criteria have claimed that this implies that the church is bound to support the view of the medical community on this issue. More recently, the Pontifical Academy of Science has upheld Catholic doctrine.<ref>"The determination of brain death and its relationship to human death." Working Group, 10-14 December 1989, pp. xxvii-210 [http://www.vatican.va/roman_curia/pontifical_academies/acdscien/own/documents/rc_acdsci_doc_190999_publications_it.html] [http://www.owensborodio.org/archives/newspaper/2000/5organ.html]</ref> Nevertheless, there was some Catholic [[dissent]] on neurological criteria for death.<ref>[http://initiative-kao.de/KAO-Braindeath_is_not_death.htm Brain death is not death]</ref> In addition, a volume consisting of essays by opponents of brain death criteria who participated in a 2005 conference at the Pontifical Academy of Sciences was published in 2006 by a publisher outside the Vatican.<ref name="Vitae" /> ==Medical criteria== A brain-dead individual has no clinical evidence of brain function upon [[physical examination]]. This includes no response to [[pain]] and no [[cranial nerve]] [[reflex]]es. Reflexes include [[Pupil constriction|pupillary response]] (fixed pupils), [[oculocephalic reflex]], [[corneal reflex]], no response to the [[caloric reflex test]] and no spontaneous [[Respiratory system|respiration]]s. It is important to distinguish between brain death and states that may mimic brain death (e.g., [[barbiturate]] [[intoxication]], [[alcohol]] [[intoxication]], [[sedative]] overdose, [[hypothermia]], [[hypoglycemia]], [[coma]] or chronic [[vegetative states]]). Some comatose patients can recover, and some patients with severe irreversible neurologic dysfunction will nonetheless retain some lower brain functions such as spontaneous respiration, despite the losses of both cortex and brainstem functionality. Thus, [[anencephaly]], in which there is no higher brain present, is generally not considered brain death, though it is certainly an irreversible condition in which it may be appropriate to withdraw life support. Note that brain electrical activity can stop completely, or drop to such a low level as to be undetectable with most equipment. This includes a ''flat [[electroencephalogram|EEG]]'' during deep [[anaesthesia]] or [[cardiac arrest]]. However, the EEG is not required in the United States, but is considered to have confirmatory value. The diagnosis of brain death needs to be rigorous to determine whether the condition is irreversible. Legal criteria vary, but it generally requires neurological exams by two independent physicians. The exams must show complete absence of brain function, and may include two isoelectric (flat-line) EEGs 24 hours apart. The widely-adopted Uniform Determination of Death Act in the [[United States]] attempts to standardize criteria. The patient should have a normal temperature and be free of drugs that can suppress brain activity if the diagnosis is to be made on EEG criteria. Alternatively, a [[radionuclide]] cerebral blood flow scan that shows complete absence of intracranial blood flow can be used to confirm the diagnosis without performing EEGs. ==Consciousness== It is presumed that a permanent cessation of electrical activity indicates the end of [[consciousness]]. Those who view the [[neo-cortex]] of the brain as solely responsible for consciousness, however, argue that electrical activity there should be the only consideration when defining death. In many cases, especially when elevated [[intracranial pressure]] prevents blood flow into the [[brain]], the entire brain is nonfunctional; however, some injuries may affect only the neo-cortex. The case of Zach Dunlap, in which a man was declared brain dead but later recovered and remembers the doctors pronouncing him dead, <ref>[http://www.news.com.au/heraldsun/story/0,21985,23427539-23109,00.html Dead man says he feels pretty good]</ref> questions this presumption. However, since he was declared dead only a few hours after presentation, he did not yet meet the [[American Academy of Neurology]]'s brain death criteria. <ref>[http://www.aan.com/professionals/practice/guidelines/pda/Brain_death_adults.pdf Determining Brain Death in Adults]</ref> While Dunlap was being disconnected from [[life support]] four hours after the pronouncement, one of his cousins, Dan Coffin, who is also a nurse, found he was responsive to [[pain]], demonstrating that he was alive, <ref>[http://today.msnbc.msn.com/id/23775873/ Pronounced dead, man takes ‘miraculous’ turn]</ref> so this example is questionable. ==Organ donation== {{Citations missing|date=April 2008}} Most organ donation for [[organ transplantation]] is done in the setting of brain death. In some nations (for instance, [[Belgium]], [[Brazil]], [[Poland]], [[Portugal]] and [[France]]) everyone is automatically an organ donor, although some jurisdictions (such as [[Singapore]]) allow opting out of the system. Elsewhere, consent from family members or next-of-kin is required for organ donation. The non-living donor is kept on ventilator support until the organs have been surgically removed. If a brain-dead individual is not an organ donor, ventilator and drug support is discontinued and cardiac death is allowed to occur. ==See also== * [[Brain stem death]] * [[Clinical death]] * [[Death]] * [[Persistent vegetative state]] ==References== {{reflist}} *Lock M. Twice Dead: Organ Transplants and the Reinvention of Death. 2002, University of California Press, Berkeley, CA. * Howsepian AA. In defense of whole-brain definitions of death. ''Linacre Quarterly''. 1998 Nov;65(4):39-61. PMID 12199254 * Karasawa H, ''et al.'' Intracranial electroencephalographic changes in deep anesthesia. ''Clin Neurophysiol.'' 2001 Jan;112(1):25-30. PMID 11137657 ==External links== * [http://theresurrector.com Informational Portal about Brain Death] * [http://www.deathreference.com/Bl-Ce/Brain-Death.html Brain Death] from the Encyclopedia of Death and Dying * [http://health.howstuffworks.com/brain-death.htm How Stuff Works - Brain Death] * [http://www.qcc.cuny.edu/socialsciences/ppecorino/DeathandDying_TEXT/Bernat_Culver_Gert.htm Textbook section] * [http://legalwikipro.com/wiki/index.php?title=Death_(OK) LegalWikiPro Article on Brain Death, Organ Donation and Civil Action for Mishandling of Dead Body under Oklahoma law] {{Death}} [[Category:Death]] [[Category:Anatomical pathology]] [[ar:موت دماغي]] [[da:Hjernedød]] [[de:Hirntod]] [[es:Muerte cerebral]] [[eo:Cerba morto]] [[fr:Mort cérébrale]] [[fy:Harsensdea]] [[ko:뇌사]] [[it:Morte cerebrale]] [[he:מוות מוחי]] [[nl:Hersendood]] [[ja:脳死]] [[no:Hjernedød]] [[pl:Śmierć mózgu]] [[pt:Morte cerebral]] [[ru:Смерть мозга]] [[fi:Aivokuolema]] [[sv:Hjärndöd]] [[th:ภาวะสมองตาย]] [[tr:Beyin ölümü]] [[yi:גסיסה]] [[zh:脑死亡]]