CD14
3764305
224267112
2008-07-08T02:03:40Z
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'''CD14''' is a membrane-associated [[glycosylphosphatidylinositol]]-linked [[protein]] expressed at the surface of cells, especially [[macrophages]].
CD14 takes its name from its inclusion in the [[cluster of differentiation]] group of cell surface marker proteins.
CD14 was the first described [[pattern recognition receptor]].
==Function==
CD14 acts as a co-receptor (along with the [[Toll-like receptor]] [[TLR 4]] and [[Ly96|MD-2]]) for the detection of bacterial [[lipopolysaccharide]].
[[Image:Toll-like receptor pathways revised.jpg|thumbnail|center|500px|Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations]]
==Production==
A soluble form '''sCD14''' is secreted by the [[liver]] and [[monocyte]]s and is sufficient in low concentrations to confer LPS-responsiveness to cells which otherwise do not express CD14.
==Differentiation==
'''CD14+''' are [[monocytes]] that can differentiate into a host of different cells. (A '+' sign refers to the presence of the CD14 protein on a cell. )
One type of cell is the [[dendritic cell]], where differentiation is encouraged by [[cytokines]]. Examples of cytokines that will cause dendritic cell differentiation includes [[GM-CSF]] and [[Interleukin-4|IL-4]].
==External links==
* {{MeshName|CD14+Antigens}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Todd RF, Petty HR |title=Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors. |journal=J. Lab. Clin. Med. |volume=129 |issue= 5 |pages= 492–8 |year= 1997 |pmid= 9142045 |doi= }}
}}
{{refend}}
{{gene-5-stub}}
{{Clusters of differentiation}}
{{Immune receptors}}
{{gene-5-stub}}
[[Category:Clusters of differentiation]]
[[ca:CD14]]
[[es:CD14]]
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