CYBB 2790413 224262022 2008-07-08T01:32:08Z ProteinBoxBot 3991663 Replaced protein Box Template with PBB Template for easy viewing. {{ otheruses4|a human gene|the airport in Canada|Kugaaruk Airport}} {{PBB|geneid=1536}} '''Cytochrome b-245, beta polypeptide (chronic granulomatous disease)''', also known as '''CYBB''' and '''P91-PHOX''', is a human [[gene]] encoding a [[glycoprotein]]. <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> {{PBB_Summary | section_title = | summary_text = Cytochrome b (-245) is composed of [[Cytochrome b-245, alpha polypeptide|cytochrome b alpha (CYBA)]] and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with [[chronic granulomatous disease]] (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.<ref>{{cite web | title = Entrez Gene: CYBB cytochrome b-245, beta polypeptide (chronic granulomatous disease)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1536| accessdate = }}</ref> }} ==References== {{reflist}} ==Further reading== {{refbegin | 2}} {{PBB_Further_reading | citations = *{{cite journal | author=Bolscher BG, de Boer M, de Klein A, ''et al.'' |title=Point mutations in the beta-subunit of cytochrome b558 leading to X-linked chronic granulomatous disease. |journal=Blood |volume=77 |issue= 11 |pages= 2482–7 |year= 1991 |pmid= 1710153 |doi= }} *{{cite journal | author=Nong Y, Kandil O, Tobin EH, ''et al.'' |title=The HIV core protein p24 inhibits interferon-gamma-induced increase of HLA-DR and cytochrome b heavy chain mRNA levels in the human monocyte-like cell line THP1. |journal=Cell. Immunol. |volume=132 |issue= 1 |pages= 10–6 |year= 1991 |pmid= 1905983 |doi= }} *{{cite journal | author=Dinauer MC, Pierce EA, Bruns GA, ''et al.'' |title=Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. |journal=J. Clin. Invest. |volume=86 |issue= 5 |pages= 1729–37 |year= 1990 |pmid= 2243141 |doi= }} *{{cite journal | author=Royer-Pokora B, Kunkel LM, Monaco AP, ''et al.'' |title=Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location. |journal=Nature |volume=322 |issue= 6074 |pages= 32–8 |year= 1986 |pmid= 2425263 |doi= 10.1038/322032a0 }} *{{cite journal | author=Dinauer MC, Curnutte JT, Rosen H, Orkin SH |title=A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease. |journal=J. Clin. Invest. |volume=84 |issue= 6 |pages= 2012–6 |year= 1990 |pmid= 2556453 |doi= }} *{{cite journal | author=Dinauer MC, Orkin SH, Brown R, ''et al.'' |title=The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex. |journal=Nature |volume=327 |issue= 6124 |pages= 717–20 |year= 1987 |pmid= 3600768 |doi= 10.1038/327717a0 }} *{{cite journal | author=Teahan C, Rowe P, Parker P, ''et al.'' |title=The X-linked chronic granulomatous disease gene codes for the beta-chain of cytochrome b-245. |journal=Nature |volume=327 |issue= 6124 |pages= 720–1 |year= 1987 |pmid= 3600769 |doi= 10.1038/327720a0 }} *{{cite journal | author=Rabbani H, de Boer M, Ahlin A, ''et al.'' |title=A 40-base-pair duplication in the gp91-phox gene leading to X-linked chronic granulomatous disease. |journal=Eur. J. Haematol. |volume=51 |issue= 4 |pages= 218–22 |year= 1994 |pmid= 7694872 |doi= }} *{{cite journal | author=Pollock JD, Williams DA, Gifford MA, ''et al.'' |title=Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. |journal=Nat. Genet. |volume=9 |issue= 2 |pages= 202–9 |year= 1995 |pmid= 7719350 |doi= 10.1038/ng0295-202 }} *{{cite journal | author=Ariga T, Sakiyama Y, Matsumoto S |title=Two novel point mutations in the cytochrome b 558 heavy chain gene, detected in two Japanese patients with X-linked chronic granulomatous disease. |journal=Hum. Genet. |volume=94 |issue= 4 |pages= 441 |year= 1994 |pmid= 7927345 |doi= }} *{{cite journal | author=Leto TL, Adams AG, de Mendez I |title=Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 22 |pages= 10650–4 |year= 1994 |pmid= 7938008 |doi= }} *{{cite journal | author=Ariga T, Sakiyama Y, Tomizawa K, ''et al.'' |title=A newly recognized point mutation in the cytochrome b558 heavy chain gene replacing alanine57 by glutamic acid, in a patient with cytochrome b positive X-linked chronic granulomatous disease. |journal=Eur. J. Pediatr. |volume=152 |issue= 6 |pages= 469–72 |year= 1993 |pmid= 8101486 |doi= }} *{{cite journal | author=Leusen JH, de Boer M, Bolscher BG, ''et al.'' |title=A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox. |journal=J. Clin. Invest. |volume=93 |issue= 5 |pages= 2120–6 |year= 1994 |pmid= 8182143 |doi= }} *{{cite journal | author=Meindl A, Carvalho MR, Herrmann K, ''et al.'' |title=A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa. |journal=Hum. Mol. Genet. |volume=4 |issue= 12 |pages= 2339–46 |year= 1996 |pmid= 8634708 |doi= }} *{{cite journal | author=Sathyamoorthy M, de Mendez I, Adams AG, Leto TL |title=p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 9141–6 |year= 1997 |pmid= 9083043 |doi= }} *{{cite journal | author=Eklund EA, Kakar R |title=Identification and characterization of TF1(phox), a DNA-binding protein that increases expression of gp91(phox) in PLB985 myeloid leukemia cells. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 9344–55 |year= 1997 |pmid= 9083071 |doi= }} *{{cite journal | author=Jendrossek V, Ritzel A, Neubauer B, ''et al.'' |title=An in-frame triplet deletion within the gp91-phox gene in an adult X-linked chronic granulomatous disease patient with residual NADPH-oxidase activity. |journal=Eur. J. Haematol. |volume=58 |issue= 2 |pages= 78–85 |year= 1997 |pmid= 9111587 |doi= }} *{{cite journal | author=Rae J, Newburger PE, Dinauer MC, ''et al.'' |title=X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase. |journal=Am. J. Hum. Genet. |volume=62 |issue= 6 |pages= 1320–31 |year= 1998 |pmid= 9585602 |doi= }} *{{cite journal | author=Ariga T, Furuta H, Cho K, Sakiyama Y |title=Genetic analysis of 13 families with X-linked chronic granulomatous disease reveals a low proportion of sporadic patients and a high proportion of sporadic carriers. |journal=Pediatr. Res. |volume=44 |issue= 1 |pages= 85–92 |year= 1998 |pmid= 9667376 |doi= }} *{{cite journal | author=Kumatori A, Faizunnessa NN, Suzuki S, ''et al.'' |title=Nonhomologous recombination between the cytochrome b558 heavy chain gene (CYBB) and LINE-1 causes an X-linked chronic granulomatous disease. |journal=Genomics |volume=53 |issue= 2 |pages= 123–8 |year= 1998 |pmid= 9790760 |doi= 10.1006/geno.1998.5510 }} }} {{refend}} ==External links== * {{MeshName|gp91phox+protein,+human}} {{oxidoreductase-stub}} {{NADH or NADPH oxidoreductases}} <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --> {{PBB_Controls | update_page = yes | require_manual_inspection = no | update_protein_box = yes | update_summary = no | update_citations = yes }}