CYP1A1
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224270366
2008-07-08T02:27:13Z
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'''CYP1A1''' is a gene that encodes a member of the [[cytochrome P450]] superfamily of enzymes. It is primarily involved in [[xenobiotic]] and [[drug metabolism]] (one substrate of it is [[theophylline]]). It is inhibited by [[fluoroquinolone]]s and [[macrolide]]s; induced by [[aromatic hydrocarbons]].
There are 3 main subtypes of CYP1A: M1, M2 and M3.
CYP1A1 and CYP1B1 are regulated by the [[Aryl hydrocarbon receptor]], a ligand activated transcription factor. They are part of the Phase I reactions in [[drug metabolism]].
CYP1A1 is also known as AHH (aryl hydrocarbon hydroxylase). It is involved in the metabolic activation of aromatic hydrocarbons ([[polycyclic aromatic hydrocarbons]], PAH), for example, [[benzopyrene]] (BP), by transforming it to [[epoxide]]. In this reaction, benzo[a]pyrene is catalysed by CYP1A1 to form BP-7,8-epoxide, then it can be further oxidized by epoxide hydrolase (EH) to form BP-7,8-dihydrodiol, and finally CYP1A1 catalyses such intermediate molecule to form [[BP-7,8-dihydrodiol-9,10-epoxide]], which is the ultimate [[carcinogen]].
==References==
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==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Beresford AP |title=CYP1A1: friend or foe? |journal=Drug Metab. Rev. |volume=25 |issue= 4 |pages= 503–17 |year= 1994 |pmid= 8313840 |doi= }}
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129–65 |year= 1999 |pmid= 9890157 |doi= }}
*{{cite journal | author=Kawajiri K |title=CYP1A1. |journal=IARC Sci. Publ. |volume= |issue= 148 |pages= 159–72 |year= 1999 |pmid= 10493257 |doi= }}
*{{cite journal | author=Nelson DR, Zeldin DC, Hoffman SM, ''et al.'' |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1–18 |year= 2004 |pmid= 15128046 |doi= }}
*{{cite journal | author=Masson LF, Sharp L, Cotton SC, Little J |title=Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review. |journal=Am. J. Epidemiol. |volume=161 |issue= 10 |pages= 901–15 |year= 2005 |pmid= 15870154 |doi= 10.1093/aje/kwi121 }}
*{{cite journal | author=Hildebrandt AG, Schwarz D, Krusekopf S, ''et al.'' |title=Recalling P446. P4501A1 (CYP1A1) opting for clinical application. |journal=Drug Metab. Rev. |volume=39 |issue= 2-3 |pages= 323–41 |year= 2007 |pmid= 17786624 |doi= 10.1080/03602530701498026 }}
}}
{{refend}}
{{genetics-stub}}
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{{Cytochrome P450}}
[[Category:Cytochrome P450]]
[[it:CYP1A1]]
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