Caffeine citrate 4354845 208151126 2008-04-25T17:41:16Z Chowbok 54304 clean up, Replaced: ® → using [[Project:AutoWikiBrowser|AWB]] {{drugbox | | IUPAC_name = 1,3,7-trimethylpurine-2,6-dione; 2-hydroxypropane-1,2,3-tricarboxylic acid | image = Caffeine citrate.png | CAS_number = 69-22-7 | ATC_prefix = | ATC_suffix = | PubChem = 6241 | DrugBank = | molecular_weight = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_US = <!-- A / B / C / D / X --> | pregnancy_category = | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S8 --> | legal_UK = <!-- GSL / P / POM / CD --> | legal_US = <!-- OTC / Rx-only --> | legal_status = | routes_of_administration = Oral, i.v. }} '''Caffeine citrate''' (Cafcit) is a [[citrate]] salt of [[caffeine]], sometimes used in medical treatment, including short-term treatment of [[apnea of prematurity]] ([[apnea|lack of breathing]] in [[premature birth|premature infants]]). Caffeine citrate functions in much the same capacity as does caffeine, but takes effect more quickly; its speed of dissociation is faster than that of caffeine. Like its sister compound, it can be used to dispel pain from a headache. However, caffeine citrate is typically only used to treat severe migraines. The drug is prepared simply by combining anhydrous caffeine with citric acid monohydrate and sodium citrate dihydrate. In method of action, the preparation is exactly identical to that of caffeine base as the citrate counter ion dissociates in water. Doses of caffeine citrate, due to the added weight of the citrate moiety, are understandably higher than with caffeine base, i.e., it takes a larger dose to get the same amount of caffeine. The ratio of therapeutic doses of caffeine base to its citrate salt is typically 1:2. == External links == * [http://ncimeta.nci.nih.gov/MetaServlet/servlet/ResultServlet2?conceptID=C0054436# Caffeine citrate entry] in the [[NCI Metathesaurus]] * [http://www.drugs.com/pdr/caffeine_citrate.html Drugs.com: Caffeine citrate] [[Category:Citrates]] [[Category:Xanthines]] [[Category:Caffeine]]