Cajal body
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2008-06-21T23:05:21Z
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{{merge|Coiled bodies|Talk:Cajal body|date=February 2008}}
'''Cajal bodies''' (CBs) are spherical sub-organelles found in the [[cell nucleus|nucleus]] of proliferative [[cell (biology)|cell]]s like [[tumor cell]]s, or metabolically active cells like [[neuron]]s. They were first reported by [[Santiago Ramón y Cajal]] in 1903, who called them ''nucleolar accessory bodies'' due to their association "with the nucleoli in neuronal cells."<ref name=Ogg_2002>{{cite journal |author=Ogg S, Lamond A |title=Cajal bodies and coilin--moving towards function |journal=J Cell Biol |volume=159 |issue=1 |pages=17–21 |year=2002 |pmid=12379800 |doi=10.1083/jcb.200206111}}</ref> Electron microscopists gave them the name "coiled body" because of their shape in EM sections. More recently, in honor of Ramón, they were termed Cajal bodies (CBs).<ref name=Ogg_2002 />
They are about 0.1 - 2.0 [[micrometre]]s and are found one to five per nucleus; the number varies over the cell cycle and in different types of cells. Cajal bodies are possibly sites of assembly or modification of the [[transcription (genetics)|transcription]] machinery of the nucleus.<ref name=Cremer_2001>{{cite journal |author=Cremer T, Cremer C |title=Chromosome territories, nuclear architecture and gene regulation in mammalian cells |journal=Nat Rev Genet |volume=2 |issue=4 |pages=292–301 |year=2001 |pmid=11283701 |doi=10.1038/35066075}}</ref>
Cajal bodies are only found in nuclei of plant, yeast, and animal cells. The cells are usually demonstrating high levels of transcriptional activity, including cells that are rapidly dividing.<ref name=Ogg_2002 />
CBs are bound to the nucleolus by [[coilin]] proteins.
{{Nucleus}}
== References ==
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[[Category:Organelles]]
{{Cell-biology-stub}}
[[ja:カハール体]]
[[pl:Ciałko Cajala]]
[[pt:Corpo de Cajal]]
[[zh:卡哈爾體]]