Carbamoyl phosphate 330893 224772446 2008-07-10T10:22:50Z 89.238.26.220 {{Chembox new | ImageFile = CarbPhos.png | ImageSize = 147px | IUPACName = | OtherNames = | Section1 = {{Chembox Identifiers | CASNo = 590-55-6 | PubChem = 278 | SMILES = C(=O)(N)OP(=O)(O)O | MeSHName = Carbamoyl+phosphate }} | Section2 = {{Chembox Properties | Formula = CH<sub>4</sub>NO<sub>5</sub>P | MolarMass = 141.020 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = }} | Section3 = {{Chembox Hazards | Solubility = | MainHazards = | FlashPt = | Autoignition = }} }} '''Carbamoyl phosphate''' is an [[anion]] of biochemical significance. It is involved In ridding the body of excess [[nitrogen]] in the [[urea cycle]], and also in the synthesis of [[pyrimidine]]s. It is produced from [[bicarbonate]], [[ammonia]], and [[phosphate]], the latter derived from [[Adenosine triphosphate|ATP]]. The synthesis is catalysed by the enzyme [[carbamoyl phosphate synthase]], as follows: * HCO<sub>3</sub><sup>-</sup> + ATP --> ADP + HO-C(O)-OPO<sub>3</sub><sup>-2</sup> (carbonyl phosphate) * HO-C(O)-OPO<sub>3</sub><sup>-2</sup> + NH<sub>3</sub> + OH<sup>-</sup> &rarr; HPO<sub>4</sub><sup>2-</sup> + [[Carbamate|<sup>-</sup>O-C(O)NH<sub>2</sub>]] + H<sub>2</sub>O *<sup>-</sup>O-C(O)NH<sub>2</sub> + ATP &rarr; ADP + H<sub>2</sub>NC(O)OPO<sub>3</sub><sup>2-</sup> ==See also== * [[Ornithine transcarbamylase]] ==References== *{{cite book | author= Nelson, David L. and Michael M. Cox | title= Lehninger Principles of Biochemistry fourth edition | publisher=W. H. Freeman and company New York}} {{Nucleotide metabolism intermediates}} [[Category:Organophosphates]] [[Category:Carbamates]] [[ast:Carbamoil fosfatu]] [[de:Carbamoylphosphat]] [[ja:カルバモイルリン酸]] [[pl:Karbamoilofosforan]]