Caspase 1 5574266 224271634 2008-07-08T02:35:23Z ProteinBoxBot 3991663 Replaced protein Box Template with PBB Template for easy viewing. {{PBB|geneid=834}} '''Caspase 1''' is an [[enzyme]] that [[proteolysis|proteolytically]] cleaves other proteins, such as the [[Protein precursor|precursor]] forms of the inflammatory [[cytokine]]s [[interleukin 1|interleukin 1-β]] and [[interleukin 18]], into active mature peptides.<ref>{{cite journal |author=Thornberry N, Bull H, Calaycay J, Chapman K, Howard A, Kostura M, Miller D, Molineaux S, Weidner J, Aunins J |title=A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes |journal=Nature |volume=356 |issue=6372 |pages=768–74 |year=1992 |pmid=1574116 |doi=10.1038/356768a0}}</ref> It belongs to a family of [[cysteine protease]]s known as [[caspase]]s that always cleave proteins following an [[aspartic acid]] residue. Caspase 1 is produced as a [[zymogen]] that is cleaved into 20 kDa (p20) and 10 kDa (p10) subunits that become part of the active enzyme. Active caspase 1 contains two [[heterodimer]]s of p20 and p10. It interacts with another [[CARD domain]] containing protein called [[PYCARD]] (or ASC) and is involved in [[inflammasome]] formation and activation of [[inflammation|inflammatory]] processes.<ref>{{cite journal |author=Mariathasan S, Newton K, Monack D, Vucic D, French D, Lee W, Roose-Girma M, Erickson S, Dixit V |title=Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf |journal=Nature |volume=430 |issue=6996 |pages=213–8 |year=2004 |pmid=15190255 |doi=10.1038/nature02664}}</ref> Caspase 1 has been shown to induce cell [[apoptosis]] and may function in various developmental stages. Studies of a similar protein in mouse suggest a role in the pathogenesis of [[Huntington's disease]]. [[Alternative splicing]] of the gene results in five transcript variants encoding distinct isoforms.<ref>{{cite web | title = Entrez Gene: CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=834| accessdate = }}</ref> ==References== <references/> {{refbegin | 2}} {{PBB_Further_reading | citations = }} {{refend}} {{protein-stub}} {{Cysteine proteases}} [[category:enzymes]] [[category:caspases]] <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --> {{PBB_Controls | update_page = yes | require_manual_inspection = no | update_protein_box = yes | update_summary = no | update_citations = yes }}