Choroid plexus cyst
1212568
214394198
2008-05-23T10:32:54Z
DOI bot
6652755
Citation enhancement. IN TRIAL: please check edit and [[User:DOI_bot/bugs|report any bugs]]. Initiated by [[User:Smith609|Smith609]]. Any concerns? Please [[User_talk:Smith609|Contact the bot's operator]].
{{Infobox_Disease |
Name = {{PAGENAME}} |
Image = |
Caption = |
DiseasesDB = |
ICD10 = {{ICD10|G|93|0|g|90}} |
ICD9 = {{ICD9|348.0}} |
ICDO = |
OMIM = |
MedlinePlus = |
eMedicineSubj = |
eMedicineTopic = |
MeshID = |
}}
'''Choroid plexus cysts''' (CPCs) are [[cyst]]s that occur within [[choroid plexus]] of the brain. The brain contains pockets or spaces called [[ventricular system|ventricles]] with a spongy layer of cells and blood vessels called the [[choroid plexus]]. This is in the middle of the fetal brain. The choroid plexus has the important function of producing a fluid called cerebrospinal fluid. The fluid produced by the cells of the choroid plexus fills the ventricles and then flows around the brain and the spinal cord to provide a cushion of fluid around these structures.
CPCs can form within this structure and come from fluid trapped within this spongy layer of cells, much like a soap bubble or a blister. CPCs are often called "soft signs" or fetal ultrasound "markers" because some studies have found a weak association between CPCs and fetal chromosome abnormalities.
It is believed that many adults have one or more tiny CPCs.<ref name="pmid15832013">{{cite journal |author=Jeon JH, Lee SW, Ko JK, ''et al'' |title=Neuroendoscopic removal of large choroid plexus cyst: a case report |journal=J. Korean Med. Sci. |volume=20 |issue=2 |pages=335–9 |year=2005 |pmid=15832013 |doi= |url=http://jkms.org/contents/jkms.php?pubyear=2005&vol=20&fpage=335}}</ref> CPCs have no impact on an individual's health or development or learning. The fetal brain may create these cysts as a normal part of development. They are temporary and usually are gone by the 32nd week of pregnancy.
==Chromosome problems==
[[Genetic counseling]] is often recommended to provide more information about fetal CPCs, to answer questions and concerns, and to outline available options such as [[amniocentesis]]. There is a possible association between ultrasound-detected fetal CPCs and [[chromosome]] problems in the baby. Types of chromosome problems that are occasionally seen include [[Trisomy 18]]<ref name="pmid17357350">{{cite journal |author=Hurt K, Sottner O, Záhumenský J, ''et al'' |title=[Choroid plexus cysts and risk of trisomy 18. Modifications regarding maternal age and markers] |language=Czech |journal=Ceska Gynekol |volume=72 |issue=1 |pages=49–52 |year=2007 |pmid=17357350 |doi=}}</ref><ref name="pmid17206726">{{cite journal |author=Papp C, Ban Z, Szigeti Z, Csaba A, Beke A, Papp Z |title=Role of second trimester sonography in detecting trisomy 18: a review of 70 cases |journal=J Clin Ultrasound |volume=35 |issue=2 |pages=68–72 |year=2007 |pmid=17206726 |doi=10.1002/jcu.20290}}</ref> or Trisomy 21 ([[Down syndrome]]).<ref name="pmid18085527">{{cite journal |author=Dagklis T, Plasencia W, Maiz N, Duarte L, Nicolaides KH |title=Choroid plexus cyst, intracardiac echogenic focus, hyperechogenic bowel and hydronephrosis in screening for trisomy 21 at 11 + 0 to 13 + 6 weeks |journal=Ultrasound Obstet Gynecol |volume= 31|issue= |pages= 132|year=2007 |pmid=18085527 |doi=10.1002/uog.5224}}</ref>
Generally the risks are low if there are no other risk factors. Some studies have estimated up to a 1% (1/100) chance of delivering a baby with a chromosome problem when there is a CPC present.
Other factors which may have a bearing on the baby's chances of developing chromosome problems include:
* mother's age at the expected date of delivery
* the results of serum screening; XAFP [[triple test]]ing or quad screening
* evidence of other "fetal findings" seen at the time of the ultrasound that may suggest a chromosome problem
Many babies with chromosome problems do not show any signs on ultrasound.
==References==
{{reflist}}
==External links==
* [http://ChoroidPlexusCyst.org The Choroid Plexus Cyst Website]
[[Category:Diseases]]