Chronic pain
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2008-06-18T10:00:18Z
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'''Chronic pain''' is defined as [[pain]] that persists longer than the temporal course of natural healing, associated with a particular type of injury or disease process.<ref name="Shipton EA, Tait B.">{{cite journal |author=Shipton EA, Tait B |title=Flagging the pain: preventing the burden of chronic pain by identifying and treating risk factors in acute pain |journal=European journal of anaesthesiology |volume=22 |issue=6 |pages=405–12 |year=2005 |pmid=15991501 |doi=10.1017/S0265021505000694}}</ref>
The International Association for the Study of Pain defines pain as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage."<ref name="merskey">{{cite journal |author=Merskey H |title=Logic, truth and language in concepts of pain |journal=Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation |volume=3 Suppl 1 |issue= |pages=S69–76 |year=1994 |pmid=7866375}}</ref> It is important to note that pain is subjective in nature and is defined by the person experiencing it, and the medical community's understanding of chronic pain now includes the impact that the mind has in processing and interpreting pain signals.
==Functional anatomy==
The anatomy of the nociceptive system can be grossly divided into the peripheral and central nervous system. The peripheral nervous system consists of small myelinated and unmyelinated nerve fibers. These nerve fibers converge into a region of the spinal cord referred to as the dorsal horn. The dorsal horn is the first relay station in pain signal transmission. The next element of pain transmission includes nerve fibers that then travel to the thalamus. From the thalamus the next order of neurons ascend to the limbic system and sensory cortex. This accounts for the affective elements and discriminative of pain respectively.<ref name="Romanelli P, Esposito V.">{{cite journal |author=Romanelli P, Esposito V |title=The functional anatomy of neuropathic pain |journal=Neurosurg. Clin. N. Am. |volume=15 |issue=3 |pages=257–68 |year=2004 |pmid=15246335 |doi=10.1016/j.nec.2004.02.010}}</ref><ref name="Vanderah TW.">{{cite journal |author=Vanderah TW |title=Pathophysiology of pain |journal=Med. Clin. North Am. |volume=91 |issue=1 |pages=1–12 |year=2007 |pmid=17164100 |doi=10.1016/j.mcna.2006.10.006}}</ref>
==Nociception==
{{main|Nociception}}
[[Nociceptor]]s convey information regarding damage or trauma from the body to the [[central nervous system]], a process called [[nociception]], where it is interpreted by the [[brain]] as [[pain]]. Nociception occurs in any tissue or organ in which pain signals arise secondary to a disease process or trauma. The nociception can also occur if there is dysfunction or damage to nerves themselves.<ref name="merskey">{{cite journal |author=Merskey H |title=Logic, truth and language in concepts of pain |journal=Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation |volume=3 Suppl 1 |issue= |pages=S69–76 |year=1994 |pmid=7866375}}</ref>
==Pathophysiology ==
Under persistent activation nociceptive transmission to the dorsal horn may induce a wind up phenomenon. This induces pathological changes that lower the threshold for pain signals to be transmitted. In addition it may generate nonnociceptive nerve fibers to respond to pain signals. Nonnociceptive nerve fibers may also be able to generate and transmit pain signals. In chronic pain this process is difficult to reverse or eradicate once established.<ref name="Vadivelu N, Sinatra R.">{{cite journal |author=Vadivelu N, Sinatra R |title=Recent advances in elucidating pain mechanisms |journal=Current opinion in anaesthesiology |volume=18 |issue=5 |pages=540–7 |year=2005 |pmid=16534290 |doi=10.1097/01.aco.0000183109.27297.75}}</ref>
==Classification==
Nociception (pain) may arise from injury or disease to visceral, somatic and neural structures in the body. More broadly pain is described as malignant or non-malignant in origin.<ref name="Vanderah TW.">{{cite journal |author=Vanderah TW |title=Pathophysiology of pain |journal=Med. Clin. North Am. |volume=91 |issue=1 |pages=1–12 |year=2007 |pmid=17164100 |doi=10.1016/j.mcna.2006.10.006}}</ref>
==Diagnoses==
Pain may be a response to injury or any number of disease states that provoke nociception. Advances in imaging studies and electrophysiological studies allow us to gain a deeper insight into the characteristics and properties associated with the phenomenon of chronic pain.<ref name="Dunckley P, Wise RG.">{{cite journal |author=Dunckley P, Wise RG, Fairhurst M, Hobden P, Aziz Q, Chang L, Tracey I |title=A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging |journal=J. Neurosci. |volume=25 |issue=32 |pages=7333–41 |year=2005 |pmid=16093383 |url=http://www.jneurosci.org/cgi/content/full/25/32/7333 |doi=10.1523/JNEUROSCI.1100-05.2005}}</ref><ref name="Geha PY, Apkarian AV.">{{cite journal |author=Geha PY, Apkarian AV |title=Brain imaging findings in neuropathic pain |journal=Current pain and headache reports |volume=9 |issue=3 |pages=184–8 |year=2005 |pmid=15907256 |doi=10.1007/s11916-005-0060-1}}</ref><ref name="Turton AJ, McCabe CS.">{{cite journal |author=Turton AJ, McCabe CS, Harris N, Filipovic SR |title=Sensorimotor integration in Complex Regional Pain Syndrome: a transcranial magnetic stimulation study |journal=Pain |volume=127 |issue=3 |pages=270–5 |year=2007 |pmid=17011705 |doi=10.1016/j.pain.2006.08.021}}</ref>
==Related sequelae==
Chronic pain may cause other symptoms or conditions, including depression and anxiety. It may also contribute to decreased physical activity given the apprehension of exacerbating pain.<ref name="Pruimboom L, van Dam AC.">{{cite journal |author=Pruimboom L, van Dam AC |title=Chronic pain: a non-use disease |journal=Med. Hypotheses |volume=68 |issue=3 |pages=506–11 |year=2007 |pmid=17071012 |doi=10.1016/j.mehy.2006.08.036}}</ref> Conversely it may itself have psychosomatic or psychogenic component to its cause.<ref>{{cite book |author=Sarno, John et al. |title=The Divided Mind: The Epidemic of Mindbody Disorders |year=2006 |publisher=ReganBooks |location=New York |isbn=0-06-085178-3 |pages=11-18}}</ref> Very little work has been done on the cognitive effects of chronic pain, with most of the publications focussing on the effects of [[cognition]] on pain but only 5% examining the effects of pain on cognition.<ref>{{cite journal | author = Kreitler S | coauthor = Niv D | year = 2007 | title = Cognitive impairment in chronic pain | journal = Pain: Clinical Updates | publisher = [[International Association for the Study of Pain]] | volume = XV | issue = 4 | pages = 1–4 | url = http://www.iasp-pain.org/AM/TemplateRedirect.cfm?template=/CM/ContentDisplay.cfm&ContentID=4132 | format = pdf | accessdate = 2008-04-15 }}</ref>
===Attention===
Chronic pain impairs the ability to direct [[attention]], in particular when compared to peers with low intensity or no chronic pain, people with high-intensity chronic pain have significantly reduced ability to perform attention-demanding tasks.<ref name="pmid7538753">{{cite journal |author=Eccleston C |title=Chronic pain and distraction: an experimental investigation into the role of sustained and shifting attention in the processing of chronic persistent pain |journal=Behav Res Ther |volume=33 |issue=4 |pages=391–405 |year=1995 |pmid=7538753 |doi=10.1016/0005-7967(94)00057-Q|url=http://linkinghub.elsevier.com/retrieve/pii/0005-7967(94)00057-Q}}</ref> The pain [[sensation]]s appear to strongly capture the attention of people with chronic pain; tests assessing the ability to attend show poorer performance than peers who do not experience chronic pain on all tests demanding attention.<ref name=Von2005>{{cite journal | author = Von Bueren Jarchow A | coauthors = Radanov BP; Jäncke, L | year = 2005 | title = Pain influences several levels of attention | journal = Zeitschrift für Neuropsychologie | volume = 16 | issue = 4 | pages = 235–242 | url = http://www.psyjournals.com/content/63h8323036164896/?p=718a7c59614c48e89417bafe1e23681b&pi=4 | accessdate = 2008-04-15| doi = 10.1024/1016-264X.16.4.235}}</ref> The exception is found with tasks that are highly demanding of attention, where performance between the two groups is equivalent.<ref name=Von2005/> In experimental testing, two-thirds of individuals with chronic pain demonstrate clinically significant impairment of attention, independent of age, education, medication and sleep disruption. Individuals with the highest levels of pain showed greatest disruption of [[Engram (neuropsychology)|memory traces]], suggesting that pain diminishes [[working memory]].<ref name="pmid17456678">{{cite journal |author=Dick BD, Rashiq S |title=Disruption of attention and working memory traces in individuals with chronic pain |journal=Anesth. Analg. |volume=104 |issue=5 |pages=1223–9, tables of contents |year=2007 |pmid=17456678 |doi=10.1213/01.ane.0000263280.49786.f5 |url = http://www.anesthesia-analgesia.org/cgi/pmidlookup?view=long&pmid=17456678 }}</ref>
==Management==
It is rare to completely achieve absolute and sustained relief of pain. Thus, the clinical goal is pain management. Pain management is often multidisciplinary in nature. A recent journal article by Gatchell and Okifuji recognizes the importance of comprehensive pain programs(CPPs) in the management of chronic pain. They summarize their findings as follows: "CPPs offer the most efficacious and cost-effective treatment for persons with chronic pain, relative to a host of widely used conventional medical treatment." <ref name="Henningsen P, Zipfel S.">{{cite journal |author=Henningsen P, Zipfel S, Herzog W |title=Management of functional somatic syndromes |journal=Lancet |volume=369 |issue=9565 |pages=946–55 |year=2007 |pmid=17368156 |doi=10.1016/S0140-6736(07)60159-7}}</ref><ref name="Stanos S, Houle TT.">{{cite journal |author=Stanos S, Houle TT |title=Multidisciplinary and interdisciplinary management of chronic pain |journal=Physical medicine and rehabilitation clinics of North America |volume=17 |issue=2 |pages=435–50, vii |year=2006 |pmid=16616276 |doi=10.1016/j.pmr.2005.12.004}}</ref>
===Medications===
In the treatment of chronic pain, whether due to malignant or benign processes, the three-step WHO Analgesic Ladder is often used.[http://www.portfolio.mvm.ed.ac.uk/studentwebs/session6/54/who_analgesic_ladder.html][http://www.allaboutpharmacy.co.uk/Formulary/Guide_to_pain_management_in_palliative_care.htm][http://www.health.nsw.gov.au/public-health/psb/chronic_pain/pf_faq4.html#what_meds] This provides guidelines for stepping up the amount of analgesia and maintains a general basis that is used in a number of countries around the world to manage chronic pain conditions. The exact medications recommended will vary with the country and the individual treatment centre, but the following gives an example of the approach to treating chronic pain with medications. If, at any point, treatment fails to provide adequate pain relief, then the doctor and patient move onto the next step.
====Mild pain====
[[Paracetamol]] (acetaminophen), or a [[non steroidal anti-inflammatory drug]] such as [[ibuprofen]]
====Mild to moderate pain====
Paracetamol, an NSAID and/or paracetamol in a combination product with a weak [[opioid]] such as [[hydrocodone]]; used in combination, may provide greater relief than their separate use.
====Moderate to severe pain====
[[Morphine]] is the gold standard choice, followed by [[Oxycodone]], [[Fentanyl]] in the form of a [[transdermal]] patch designed for chronic pain management, [[Diamorphine]], [[hydromorphone]] or [[methadone]] are used less frequently.
[[Pethidine]] is not recommended for chronic pain management due to its low potency, short duration of action, and toxicity associated with repeated use.
====Opioids====
[[Opioid]] medications can provide a short, intermediate or long acting analgesia depending upon the specific properties of the medication and whether it is formulated as an extended release drug. Opioid medications may be administered orally, by injection, via nasal mucosa or oral mucosa, rectal, transdermal, intravenously, epidurally and intrathecally. In chronic pain conditions that are opioid responsive a combination of a long acting or extended release medication is often prescribed in conjunction with a shorter acting medication for break through pain (exacerbations).
Most opioid treatment is oral ([[tablet]], [[capsule]] or liquid), but [[suppositories]] and skin patches can be prescribed. An opioid [[injection]] is rarely needed for patients with chronic pain.
Although opioids are strong analgesics, they do not provide complete analgesia regardless of whether the pain is acute or chronic in origin. Opioids are efficacious analgesics in chronic malignant pain and modestly effective nonmalignant pain management. However, there are variable associated adverse effects, especially during the commencement or change in dosing and administration. When [[opioids]] are used for prolonged periods [[drug tolerance]], [[chemical dependency]] and (rarely) [[addiction]] may occur. [[Chemical dependency]] is ubiquitous among [[opioid]] therapy after continuous administration; however, [[drug tolerance]] is not well studied in patients on long term opioid therapy. [[Addiction]] rarely occurs as a result of opioid prescription, but they are abused by some individuals, which can cause concern to health care providers. Diversion of opioid medications is another concern for health care providers.
====Non-steroidal anti-inflammatory drugs====
The other major group of analgesics are [[Non-steroidal anti-inflammatory drug]]s (NSAID). This class of medications does not include [[acetaminophen]], which has minimal anti-inflammatory properties. However, acetaminophen may be administered as a single medication or in combination with other analgesics (both NSAIDs and opioids). The alternatively prescribed NSAIDs such as ketoprofen and piroxicam, have limited benefit in chronic pain disorders and with long term use is associated with significant adverse effects. The use of selective NSAIDs designated as selective COX-2 inhibitors have significant cardiovascular and cerebrovascular risks which have limited their utilization.<ref name="Munir MA, Enany N.">{{cite journal |author=Munir MA, Enany N, Zhang JM |title=Nonopioid analgesics |journal=Med. Clin. North Am. |volume=91 |issue=1 |pages=97–111 |year=2007 |pmid=17164106 |doi=10.1016/j.mcna.2006.10.011}}</ref><ref name="Ballantyne JC.">{{cite journal |author=Ballantyne JC |title=Opioids for chronic nonterminal pain |journal=South. Med. J. |volume=99 |issue=11 |pages=1245–55 |year=2006 |pmid=17195420 |doi=10.1073/pnas.0705740104.<br |doilabel=10.1073/pnas.0705740104.<br}}</ref>
====Antidepressants and antiepileptic drugs====
Some [[antidepressant]] and [[antiepileptic]] drugs are used in chronic pain management and act primarily within the pain pathways of the central nervous system, though peripheral mechanisms have been attributed as well. These mechanisms vary and in general are more effective in [[neuropathy|neuropathic]] pain disorders as well as [[complex regional pain syndrome]].<ref name="Jackson KC 2nd.">{{cite journal |author=Jackson KC |title=Pharmacotherapy for neuropathic pain |journal=Pain practice : the official journal of World Institute of Pain |volume=6 |issue=1 |pages=27–33 |year=2006 |pmid=17309706}}</ref> Drugs such as [[Gabapentin]] have been widely prescribed for the off-label use of pain control. The list of side effects for these classes of drugs are typically much longer than opiate or NSAID treatments for chronic pain, and many antiepileptics cannot be suddenly stopped without the risk of [[seizure]].
====Other Adjuvant & Atypical Analgesic Agents====
Other drugs are often used to help analgesics combat various types of pain and parts of the overall pain experience. In addition to [[gabapentin]], the vast majority of which is used off-label for this purpose, [[orphenadrine]], [[cyclobenzaprine]], [[trazadone]] and other drugs with anticholinergic properties are useful in conjunction with opioids for neuropathic pain. The latter three drugs are also muscle relaxants and are therefore particularly useful in painful musculoskeletal conditions. [[Clonidine]] has found use as an analgesic for this same purpose and all of the mentioned drugs potentiate the effects of opioids overall.
===Interventional therapy===
[[Pulsed radiofrequency]], [[neuromodulation]], direct introduction of medication and nerve [[ablation]] may be used to target either the tissue structures and organ/systems responsible for persistent [[nociception]] or the [[nociceptors]] from the structures implicated as the source of chronic pain.<ref name="Varrassi G, Paladini A">{{cite journal |author=Varrassi G, Paladini A, Marinangeli F, Racz G |title=Neural modulation by blocks and infusions |journal=Pain practice : the official journal of World Institute of Pain |volume=6 |issue=1 |pages=34–8 |year=2006 |pmid=17309707}}</ref><ref name="Meglio M.">{{cite journal |author=Meglio M |title=Spinal cord stimulation in chronic pain management |journal=Neurosurg. Clin. N. Am. |volume=15 |issue=3 |pages=297–306 |year=2004 |pmid=15246338 |doi=10.1016/j.nec.2004.02.012}}</ref><ref>{{cite journal |author=Rasche D, Ruppolt M, Stippich C, Unterberg A, Tronnier VM |title=Motor cortex stimulation for long-term relief of chronic neuropathic pain: a 10 year experience |journal=Pain |volume=121 |issue=1-2 |pages=43–52 |year=2006 |pmid=16480828 |doi=10.1016/j.pain.2005.12.006}}</ref><ref name="Boswell MV, Trescott AM">{{cite journal |author=Boswell MV, Trescot AM, Datta S, Schultz DM, Hansen HC, Abdi S, Sehgal N, Shah RV, Singh V, Benyamin RM, Patel VB, Buenaventura RM, Colson JD, Cordner HJ, Epter RS, Jasper JF, Dunbar EE, Atluri SL, Bowman RC, Deer TR, Swicegood JR, Staats PS, Smith HS, Burton AW, Kloth DS, Giordano J, Manchikanti L |title=Interventional techniques: evidence-based practice guidelines in the management of chronic spinal pain |journal=Pain physician |volume=10 |issue=1 |pages=7–111 |year=2007 |pmid=17256025|url=http://www.painphysicianjournal.com/2007/january/2007;10;7-111.pdf?PHPSESSID=ea188711febadee5420f1c9061ebd249 |format=PDF}}</ref><ref name="Romanelli P, Esposito V">{{cite journal |author=Romanelli P, Esposito V, Adler J |title=Ablative procedures for chronic pain |journal=Neurosurg. Clin. N. Am. |volume=15 |issue=3 |pages=335–42 |year=2004 |pmid=15246341 |doi=10.1016/j.nec.2004.02.009}}</ref>
An [[intrathecal pump]] used to delivery very small quantities of medications directly to the spinal fluid. This is similar to epidural infusions used in labour and postoperatively. The major differences are that it is much more common for the drug to be delivered into the spinal fluid (intrathecal) rather than epidurally, and the pump can be fully implanted under the skin. This approach allows the drug to be delivered directly to the site of action, ie the spinal cord, and so allows a higher dose to be given with less systemic side effects.<ref name="pmid1952133">{{cite journal|author=Ferrante FM, Lu L, Jamison SB, Datta S|title=Patient-controlled epidural analgesia: demand dosing|journal=Anesth. Analg.|volume=73|issue=5|pages=547–52|year=1991|pmid=1952133|doi=10.1213/00000539-199111000-00006}}</ref>
A [[spinal cord stimulator]] is an implantable medical device that creates electric impulses and applies them near the dorsal surface of the spinal cord provides a [[paresthesia]] ("tingling") sensation that alters the perception of pain by the patient.
===Rehabilitation===
{{see|Physical medicine and rehabilitation}}
As alluded to earlier there are other modalities used in the treatment of chronic pain. These include: physical modalities such as thermal agents and [[electrotherapy]]. Complementary and alternative medicine, therapeutic exercise and behavioral therapy are also utilized autonomously or in tandem with interventional techniques and conventional pharmacotherapy. This is most often structured in a multidisciplinary or interdisciplinary program.<ref name="Geertzen JH, Van Wilgen CP.">{{cite journal |author=Geertzen JH, Van Wilgen CP, Schrier E, Dijkstra PU |title=Chronic pain in rehabilitation medicine |journal=Disability and rehabilitation |volume=28 |issue=6 |pages=363–7 |year=2006 |pmid=16492632 |doi=10.1080/09638280500287437}}</ref>
===Behavioral therapy===
{{main|Behavioral therapy}}
{{main|Applied behavior analysis}}
[[Applied behavior analysis]] treats pain as mixture of respondent and [[operant conditioning]] in which normal [[tissue (biology)|tissue]]s learn to fire pain responses in the presence of specific environmental antecedents and consequences. The model was first proposed by Fordyce in 1976.<ref name="isbn0-8016-1621-2">{{cite book |author=Fordyce, Wilbert E |title=Behavioral methods for chronic pain and illness |publisher=Mosby |location=St. Louis |year=1976 |pages= |isbn=0-8016-1621-2 |oclc= |doi=}}</ref><ref name=Fordyce1988>{{cite journal | author = Fordyce, W.E. | year = 1988 | title = Pain and suffering. A reappraisal. | journal = Am Psychol | volume = 43 | issue = 4 | pages = 276–83 | doi = 10.1037/0003-066X.43.4.276}}</ref> There is mixed support for behavioral treatment of pain, with many studies reporting positive results,<ref name=Romano2000>{{cite journal | author = Romano, J.M. | coauthors = Jensen, M.P.; Turner, J.A.; Good, A.B.; Hops, H. | year = 2000 | title = Chronic pain patient-partner interactions: Further support for a behavioral model of chronic pain | journal = Behavior Therapy | volume = 31 | issue = 3 | pages = 415–440 | url = http://linkinghub.elsevier.com/retrieve/pii/S0005789400800234 | accessdate = 2008-04-15 | doi = 10.1016/S0005-7894(00)80023-4}}</ref><ref name=Sanders2006>{{cite journal | author = Sanders, S.H. | coauthors = Chattanooga, T. | year = 2006 | title = Behavioral Conceptualization and Treatment for Chronic Pain | journal = A Context for Science with a Commitment to Behavior Change | volume = 7 | issue = 2 | url = http://www.behavior-analyst-today.com/VOL-7/BAT-7-2.PDF#page=95 | accessdate = 2008-04-15 | format = {{dead link|date=June 2008}} – <sup>[http://scholar.google.co.uk/scholar?hl=en&lr=&q=intitle%3ABehavioral+Conceptualization+and+Treatment+for+Chronic+Pain&as_publication=A+Context+for+Science+with+a+Commitment+to+Behavior+Change&as_ylo=2006&as_yhi=2006&btnG=Search Scholar search]</sup>}}</ref><ref name="pmid2967314">{{cite journal |author=Turner JA, Clancy S |title=Comparison of operant behavioral and cognitive-behavioral group treatment for chronic low back pain |journal=J Consult Clin Psychol |volume=56 |issue=2 |pages=261–6 |year=1988 |pmid=2967314 |doi= |url=http://content.apa.org/journals/ccp/56/2/261}}</ref><ref name="pmid2147702">{{cite journal |author=Turner JA, Clancy S, McQuade KJ, Cardenas DD |title=Effectiveness of behavioral therapy for chronic low back pain: a component analysis |journal=J Consult Clin Psychol |volume=58 |issue=5 |pages=573–9 |year=1990 |pmid=2147702 |doi= |url=http://content.apa.org/journals/ccp/58/5/573}}</ref> though a review of studies in 2005 suggested that though behavioral can be an effective and economical means of treating chronic pain, a substantial portion of patients do not benefit from behavior therapy, that effects are rather modest, and there is little evidence to support different treatment modalities have different effects.<ref name="pmid15599126">{{cite journal |author=Vlaeyen JW, Morley S |title=Cognitive-behavioral treatments for chronic pain: what works for whom? |journal=Clin J Pain |volume=21 |issue=1 |pages=1–8 |year=2005 |pmid=15599126 |doi= |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0749-8047&volume=21&issue=1&spage=1}}</ref>
===Biofeedback===
{{main|Biofeedback}}
[[Biofeedback]] based on behavioral principles has shown some success for chronic pain, demonstrating greater improvement in one study than peers undergoing cognitive-behavioral therapy and conservative medical treatment,<ref>{{cite journal | last = Flor | first = H | coauthors = Birbaumer N | year = 1993 | title = Comparison of the efficacy of cicctromyographic biofeedback, cognitive behavior therapy, and conservative medical treatment for chronic skeletal pain | journal = Journal of Consulting and Clinical Psychology | volume = 61 | issue = 4 | pages = 653–658 | url = http://content.apa.org/journals/ccp/61/4/653 | accessdate = 2008-04-15 | doi = 10.1037/0022-006X.61.4.653 }}</ref> though a different study showed improvements over wait-list controls but no difference between biofeedback and cognitive-behavioral therapy.<ref name="pmid7654161">{{cite journal |author=Newton-John TR, Spence SH, Schotte D |title=Cognitive-behavioural therapy versus EMG biofeedback in the treatment of chronic low back pain |journal=Behav Res Ther |volume=33 |issue=6 |pages=691–7 |year=1995 |pmid=7654161|doi=10.1016/0005-7967(95)00008-L}}</ref>
==See also==
{{col-begin|width=95%}}
|-
|
* [[Suffering]]
;Conditions related to [[pain]]:
* [[Arthritis]]
* [[Back pain]]
* [[Cancer]]
* [[Complex Regional Pain Syndrome]]
* [[Clinical depression]]
* [[Fibromyalgia]]
* [[Headache]]
* [[Sciatica]]
;Drugs:
* [[Analgesia]]
* [[Antiepileptics]]
** [[Gabapentin]]
** [[Pregabalin]]
** [[Levetiracetam]]
** [[Topiramate]]
** [[Lamotrigine]]
** [[Zonisamide]]
* [[Antidepressants]]
* [[Local anesthetics]]
** [[Ketamine]]
* [[Acetaminophen]] (Paracetamol)
* [[NSAIDs]]
* [[Opioids]]
* Other agents:
**[[Clonidine]]
** [[Ziconotide]]
|
;Other approaches in [[Physical medicine and rehabilitation]] (Physiatry):
* [[Cryotherapy]]
* [[Exercise]]
* [[Hot pack]]
* [[Occupational therapy]]
* [[Physical therapy]]
* [[TENS]]
;Alternative therapies:
* [[Acupuncture]]
* [[Behavioral therapy]]
* [[Chiropractic]]
* [[Massage therapy]]
* [[Prolotherapy]]
;Surgery:
* [[Spinal cord stimulation]]
|}
==Footnotes==
{{reflist}}
==External links==
* [http://www.theacpa.org/ American Chronic Pain Association]
* [http://www.painfoundation.org/ American Pain Foundation]
* [http://www.iasp-pain.org/ International Association for the Study of Pain- IASP]
* [http://www.ampainsoc.org/people/ Patient consumer web page sponsored by the APS]
{{Pain}}
{{General symptoms and signs}}
[[Category:Nociception]]
[[Category:Pain]]
[[ca:Dolor crònic]]
[[nl:Chronische pijn]]