Climbing fiber 2412194 201502513 2008-03-28T04:13:49Z Arcadian 104523 nav {{Infobox_neuron |neuron_name = Climbing fiber |image_neuron = CerebCircuit.png |caption_neuron= Microcircuitry of the cerebellum. [[Excitatory synapses]] are denoted by (+) and [[inhibitory synapses]] by (-). Climbing fiber is shown originating from the inferior olive (green). |location = [[Inferior Olive]] and [[Cerebellum]] |function = Unique excitatory function (see text) |neurotranmitter = [[Glutamate]] |morphology = Unique projection neuron (see text) |afferents = [[Inferior olive]] |efferents = [[Purkinje cells]] |GraySubject = 187 |GrayPage = 796 }} {{Unreferenced|date=January 2007}} '''Climbing fibers''' are the name given to a series of [[neuron|neuronal]] projections from the [[inferior olivary nucleus]] located in the [[medulla]]. These [[axon]]s pass through the [[pons]] and enter the [[cerebellum]] where they form [[synapse]]s with the [[Cerebellum#Deep Nuclei|deep cerebellar nuclei]] and [[Purkinje cell]]s. Each climbing fiber will form synapses with 1-10 Purkinje cells. Early in development, Purkinje cells are innervated by multiple climbing fibers, but as the cerebellum matures, these inputs gradually become eliminated resulting in a single climbing fiber input per Purkinje cell. These fibers provide very powerful, [[excitatory]] input to the cerebellum which results in the generation of complex spikes in Purkinje cells. Climbing fiber activation is thought to serve as a motor error signal sent to the cerebellum, and is an important signal for [[motor timing]]. These Climbing fibres carry information to various sources such as the [[spinal cord]], [[vestibular system]], [[red nucleus]], [[superior colliculus]], [[reticular formation]] and sensory and motor cortices. ==External links== * {{NeuroanatomyWisc|cere/text/P4/climb.htm}} {{neuroanatomy-stub}} {{Cerebellum}} [[Category:Central nervous system]] [[Category:Cerebellum]] [[Category:Brainstem]]