Complex partial seizure 2205957 225003871 2008-07-11T12:18:27Z JaGa 2092487 Reverted edits by [[Special:Contributions/78.144.149.220|78.144.149.220]] to last version by 81.96.143.59 (using [[WP:HG|Huggle]]) {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = | ICD10 = {{ICD10|G|40|2|g|40}}| ICD9 = {{ICD9|345.4}} | ICDO = | OMIM = | MedlinePlus = 000699 | eMedicineSubj = neuro | eMedicineTopic = 74 | MeshID = D017029 | }} A '''complex partial seizure''' is an [[epilepsy|epileptic]] [[seizure]] that is limited to one [[cerebral hemisphere]] and causes [[impairment]] of [[awareness]] or [[responsiveness]].<ref>Trescher, William H., and Ronald P. Lescher 2000, p. 1748.</ref> ==Presentation== Complex partial seizures are often preceded by a [[seizure]] [[aura (symptom)|aura]].<ref> Trescher, William H., and Ronald P. Lescher 2000, p. 1749.</ref> The seizure aura is a [[simple partial seizure]].<ref>Trescher, William H., and Ronald P. Lescher 2000, p. 1749.</ref> The seizure [[aura (symptom)|aura]] might occur as a feeling of [[déjà vu]], [[jamais vu]], fear, [[euphoria]], or [[depersonalization]].<ref>Murro, Anthony M. 2006.</ref> The seizure [[aura (symptom)|aura]] might occur as a visual disturbance, such as [[tunnel vision]] or a change in the size of objects ([[macropsia]] or [[micropsia]]).<ref> Engelsen, B A., C Tzoulis, B Karlsen, A Lillebø, L M 2008.</ref> Once consciousness is impaired, the person may display [[Wiktionary:automatism|automatism]]s such as lip smacking, chewing, or swallowing.<ref>Murro, Anthony M. 2006.</ref> There may also be loss of memory ([[amnesia]]) surrounding the seizure event.<ref>Trescher, William H., and Ronald P. Lescher 2000, p. 1749.</ref> The person may still be able to perform routine tasks such as walking or shopping. Witnesses may not recognize that anything is wrong. Complex partial seizures might arise from any [[lobe (anatomy)|lobe]] of the brain.<ref>Trescher, William H., and Ronald P. Lescher 2000, p. 1749.</ref> Complex partial seizures most commonly arise from the [[Wiktionary:medial|medial]] [[temporal lobe]], particularly the [[amygdala]], [[hippocampus]] and [[Wiktionary:neocortex|neocortical]] regions.<ref>Trescher, William H., and Ronald P. Lescher 2000, p. 1750.</ref> A common associated brain abnormality is [[mesial temporal sclerosis]].<ref>Murro, Anthony M. 2006.</ref> Mesial temporal sclerosis is a specific pattern of hippocampal neuronal loss accompanied by hippocampal gliosis and atrophy.<ref>Trepeta, Scott 2007.</ref> Complex partial seizures occur when excessive and synchronous electrical brain activity causes impaired awareness and responsiveness.<ref>"International League Against Epilepsy." 2008.</ref> The abnormal electrical activity might spread to the rest of the brain and cause a secondary generalized [[tonic-clonic seizure]].<ref>Trescher, William H., and Ronald P. Lescher 2000, p. 1747.</ref> == Creativity & Epilepsy == Some observations suggest that complex partial seizures might enhance creativity.<ref>Natalie Angier: [http://query.nytimes.com/gst/fullpage.html?res=9F0CEEDC123FF931A25753C1A965958260 In the Temporal Lobes, Seizures and Creativity]. [[New York Times]], October 12, 1993.</ref> However, research studies have generated conflicting results. In 2002, researchers at the Guelhane Military Medical Academy in Turkey evaluated thirty men with epilepsy and thirty-six men without. The men were instructed to use fragmented parts of a drawing to create a picture of their own. Those with complex partial seizures scored higher than their counterparts.<ref>E. Togrol, A. Togrol, S. Can: [http://congress.akm.ch/abstract/abstract/abt.ausg_pkt_ses?xssprache=ENG&xsdesign=OPT&xnkon_nr=129&xnSESSION_NR=5496&xnCO_PROFILE=373614# Creative thinking in epilepsy]. [[Boğaziçi University]], 2002.</ref> A 2004 study suggested that temporal lobe epilepsy was not associated with their measure of creativity.<ref>[http://www.leaonline.com/doi/abs/10.1207/s15326934crj1601_3 Temporal lobe Epilepsy and Creativity: A Model of Association]</ref> ==Complex partial seizures and religious hallucinations== There are several religious figures suspected of having complex partial seizures. Ezekiel could have suffered from complex seizures.<ref> [http://www.newscientist.com/channel/health/mental-health/dn1565.html Old Testament prophet showed epileptic symptoms] </ref> Though her supporters disagree, the founder of the [[Seventh-day Adventist Church]], [[Ellen G. White]]'s visions of God may have been caused by partial seizures. She had previously lost consciousness from a head injury.<ref> [http://www.ellenwhite.org/seizures.htm The Ellen White Research Project] </ref> Her brain injury was significant enough to prevent her return to school. ==See also== * [[List of people with epilepsy]] == Notes == {{reflist}} ==References== * Engelsen, B A., C Tzoulis, B Karlsen, A Lillebø, L M. Laegreid, J Aasly, M Zeviani, and L A. Bindoff. "POLG1 Mutations Cause a Syndromic Epilepsy with Occipital Lobe Predilection." Brain 131 (2008): 818-828. * "International League Against Epilepsy." 2008. International League Against Epilepsy. Accessed 9 Apr. 2008 <http://www.ilae-epilepsy.org/>. * Murro, Anthony M. "eMedicine - Complex Partial Seizures." 11 Oct. 2006. Medical College of Georgia. Accessed 9 Apr. 2008 <http://www.emedicine.com/neuro/topic74.htm>. * Natalie Angier: [http://query.nytimes.com/gst/fullpage.html?res=9F0CEEDC123FF931A25753C1A965958260 In the Temporal Lobes, Seizures and Creativity]. [[New York Times]], October 12, 1993. * Togrol E., Togrol A., S. Can: [http://congress.akm.ch/abstract/abstract/abt.ausg_pkt_ses?xssprache=ENG&xsdesign=OPT&xnkon_nr=129&xnSESSION_NR=5496&xnCO_PROFILE=373614# Creative thinking in epilepsy]. [[Boğaziçi University]], 2002. * Trepeta, Scott. "eMedicine - Mesial Temporal Sclerosis." 11 Sept. 2007. Jamaica Hospital. Accessed 9 Apr. 2008 <http://www.emedicine.com/radio/topic443.htm>. * Trescher, William H., and Ronald P. Lescher. "The Epilepsies." Neurology in Clinical Practice. Ed. Walter G. Bradley, Robert B. Daroff, Gerald M. Fenichel, and C. David Marsden. Boston: Butterworth-Heinemann, 2000. 1745-1780. * [http://www.epilepsy.org.uk/node/694 Epilepsy Action - Link Between Complex Partial Epilepsy and Creativity] * [http://www.leaonline.com/doi/abs/10.1207/s15326934crj1601_3 Temporal Lobe Epilepsy and Creativity: A Model of Association] * [http://www.newscientist.com/channel/health/mental-health/dn1565.html Old Testament prophet showed epileptic symptoms] {{Diseases of the nervous system}} [[Category:Neurology]] [[Category:Symptoms]] [[Category:Epilepsy]] [[it:Crisi parziale complessa]]