Conversion disorder 880777 220291781 2008-06-19T04:00:14Z Brenont 4034676 /* Treatment */ wikilinks {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = 1645 | ICD10 = {{ICD10|F|44||f|40}} | ICD9 = {{ICD9|300.11}} | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = emerg | eMedicineTopic = 112 | eMedicine_mult = {{eMedicine2|med|1150}} | MeshID = D003291 }} '''Conversion disorder''' is a condition where patients present with neurological symptoms such as [[numbness]], [[paralysis]], or [[Psychogenic non-epileptic seizures|fits]], but where no neurological explanation can be found. It is thought that these problems arise in response to difficulties in the patient's life, and conversion is considered a [[mental disorder|psychiatric disorder]] in the International Statistical Classification of Diseases and Related Health Problems ([[ICD-10]])<ref>The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. Geneva, World Health Organization, 1992</ref> and Diagnostic and Statistical Manual of Mental Disorders 4th edition ([[DSM-IV]]).<ref>Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, American Psychiatric Association</ref> Formerly known as '[[Female hysteria|hysteria]]', the disorder has arguably been known for millennia, though it came to greatest prominence at the end of the 19th century, when the neurologist [[Jean-Martin Charcot]], and psychiatrists [[Pierre Janet]] and [[Sigmund Freud]] made it the focus of their study. The term 'conversion' has its origins in Freud's doctrine that anxiety is 'converted' into physical symptoms.<ref>Josef Breuer & Sigmund Freud, "Studies in Hysteria", 1895</ref> Though previously thought to have vanished from the west in the 20th century, new research has suggested it is as common as ever.<ref>Akagi, H. & House, A.O., 2001, The epidemiology of hysterical conversion. In P. Halligan, C. Bass, J. Marshall (Eds.) Hysterical Conversion: clinical and theoretical perspectives (pp.73-87). Oxford: Oxford University Press.</ref> ==Definition== DSM-IV defines conversion disorder as follows: *One or more symptoms or deficits are present that affect voluntary motor or sensory function suggestive of a neurologic or other general medical condition. *Psychological factors are judged, in the clinician's belief, to be associated with the symptom or deficit because conflicts or other stressors precede the initiation or exacerbation of the symptom or deficit. A diagnosis where the stressor precedes the onset of symptoms by up to 15 years is not unusual. *The symptom or deficit is not intentionally produced or feigned (as in [[factitious disorder]] or [[malingering]]). *The symptom or deficit, after appropriate investigation, cannot be explained fully by a general medical condition, the direct effects of a substance, or as a culturally sanctioned behavior or experience. *The symptom or deficit causes clinically significant distress or impairment in social, occupational, or other important areas of functioning or warrants medical evaluation. *The symptom or deficit is not limited to pain or [[sexual dysfunction]], does not occur exclusively during the course of [[somatization disorder]], and is not better accounted for by another [[Mental illness|mental disorder]]. The nature of the association between the psychological factors and the neurological symptoms remains unclear. Earlier versions of the [[DSM-IV]] employed [[psychodynamic]] concepts, but these have been incrementally removed from successive versions. The [[ICD-10]] classifies conversion disorder as dissociative (conversion) disorder, which suggests the symptoms arise through the process of [[dissociation (psychology)|dissociation]]. ==History== In the 19th century, physicians such as [[Silas Weir Mitchell]] in the US and [[Paul Briquet]] and [[Jean-Martin Charcot]] in France developed ideas about patients sharing unexplained neurological symptoms. Charcot specialised in treating patients who were suffering from a variety of unexplained physical symptoms including paralysis, contractures (muscles which contract and cannot be relaxed) and seizures. Some of these patients sporadically and compulsively adopted a bizarre posture (christened ''arc-de-cercle'') in which they arched their body backwards until they were supported only by their head and their heels. The term "Conversion disorder" originated with Freud and the psychotherapy movement. He viewed these apparently neurological symptoms as a result of the conversion of intrapsychic distress in to physical symptoms. Much of Freud's work is now viewed with [[Freud#Critical reactions|scepticism]], and it has been suggested that at least some of the classic psychoanalytic cases of hysteria, such as "[[Anna O.]]"<ref>Alison Orr-Andrewes, "The case of Anna O: A Neuropsychiatric perspective", ''Journal of the Psychoanalytic Association'' 1987, vol '''35''' p.399.</ref>, may actually have suffered from organic illness. Historically, conversion disorder was thought to manifest itself in many different ways. Conversion disorders were thought to be triggered by acute psychosocial stress that the individual could not process psychologically. This overwhelming distress was thought to cause the brain to unconsciously disable or impair a bodily function which would relieve or prevent the patient from experiencing this stressor again. This is in contrast to a more modern understanding that patients remain distressed by their symptoms in the long term<ref>Stone, ''et al'', ''JR Soc Med'' 2005; '''98''':547-548</ref>. ==Presentation== Conversion disorder can present with any motor or sensory symptom including *Weakness/paralysis of a limb or the entire body ([[hysterical paralysis]] or [[motor conversion disorder]]s) *Impaired hearing or vision *Loss/disturbance of sensation *Impairment or loss of speech (hysterical [[aphonia]]) *[[Psychogenic non-epileptic seizures]] *Fixed Dystonia unlike normal dystonia *Tremor, myoclonus or other movement disorders *Gait problems ([[Astasia-abasia]]) ==Diagnosis== The diagnosis of conversion disorder involves three elements - the exclusion of neurological disease, the exclusion of feigning, and the determination of a psychological mechanism. Each of these has difficulties. ===Exclusion of neurological disease=== Conversion disorder presents with symptoms that typically resemble a neurological disorder such as stroke, multiple sclerosis, or epilepsy. The neurologist must carefully exclude neurological disease, through examination and appropriate investigations.<ref>Stone J, Carson A, Sharpe M., 2005, Functional symptoms in neurology: Assessment, Journal of Neurology, Neurosurgery and Psychiatry (Neurology in Practice); 76 (Suppl 1): 2-12</ref> However, it is not uncommon for patients with neurological disease to also have conversion disorder<ref>Eames P, 1992, "Hysteria following brain injury", Journal of Neurology, Neurosurgery, and Psychiatry, Vol 55, 1046-1053</ref>, in which case the task becomes to determine how much of the patient's problem is due to conversion.{{Dubious|date=March 2008}} In excluding neurological disease, the neurologist has traditionally relied partly on the presence of positive signs of conversion disorder - certain aspects of the presentation that were thought to be rare in neurological disease, but common in conversion. The validity of many of these signs has been questioned, however, by a study showing that they also occurred in neurological disease.<ref>Gould R, Miller B L, Goldberg M A, Benson D F, 1986, The validity of hysterical signs and symptoms, The Journal of nervous and mental disease, vol. 174, no10, pp. 593-597</ref> One such symptom, for example, is ''La belle indifférence'', described in DSM-IV as "a relative lack of concern about the nature or implications of the symptoms". In a later study no evidence was found that patients with 'functional' symptoms are any more likely to exhibit this than patients with a confirmed organic disease.<ref>Stone J, Smyth R, Carson A, Warlow C, Sharpe M., "La belle indifference in conversion symptoms and hysteria: systematic review." ''Br J Psychiatry''. 2006 Mar;'''188''' pp.204-9.</ref> Another feature thought to be important was that symptoms would tend to be more severe on the non-dominant (usually left) side; there were a variety of theories such as the relative involvement of cerebral hemispheres in emotional processing, or more simply just that it was "easier" to live with a functional deficit on the non-dominant side. However, a literature review of 121 studies established that this was not true, with [[publication bias]] the most likely explanation for this commonly held view.<ref>Stone J, Sharpe M, Carson A, Lewis SC, Thomas B, Goldbeck R, Warlow CP. "Are functional motor and sensory symptoms really more frequent on the left? A systematic review." ''J Neurol Neurosurg Psychiatry.'' 2002 Nov;'''73'''(5) pp.578-81.</ref> The process of exclusion is not perfect, so misdiagnoses will occur. However, in a highly influential{{Fact|date=January 2008}} study from the 1960s, Eliot Slater demonstrated that misdiagnoses had occurred in one third of his 112 patients with conversion disorder.<ref>Slater ET, Glithero E. "A follow-up of patients diagnosed as suffering from 'hysteria' ''J Psychosom Res'' 1965 Sep;'''9'''(1) pp.9-13.</ref> Later authors have argued that the paper was flawed, however<ref>Ron M, "The Prognosis of Hysteria" In P. Halligan, C. Bass, J. Marshall (Eds.) Hysterical Conversion: clinical and theoretical perspectives (pp.73-87). Oxford: Oxford University Press.</ref> <ref>Stone, ''et al'', ''JR Soc Med'' 2005; '''98''':547-548</ref>, and a meta-analysis has shown that misdiagnosis rates since that paper are around 4%, the same as for other neurological diseases<ref>Stone, ''et al'', ''BMJ'' 2005</ref>. ===Exclusion of feigning=== Conversion disorder is unique in DSM-IV in requiring the exclusion of deliberate feigning in order to make the diagnosis. Unfortunately, this is no easier for conversion disorder than it is for other illness{{Fact|date=December 2007}}, and is only very rarely established, by video surveillance, or by the patient's confession{{Fact|date=December 2007}}. A neuroimaging study suggested that feigning may be distinguished from conversion by the pattern of frontal lobe activation<ref>Spence SA, Crimlisk HL, Cope H, Ron MA, Grasby PM. "Discrete neurophsyiological correlates in prefrontal cortex during hysterical and feigned disorder of movement." Lancet 2000 Apr 8; 355(9211), pp.1243-4.</ref>; however this has not been demonstrated outside of a research setting. True rates of feigning in medicine remain unknown, though neurological presentations of feigning may be among the more common<ref>Eckhardt A, "Factitious disorders in the field of neurology and psychiatry." 1994; 62(1-2), pp.56-62.</ref> ===Establishing a psychological mechanism=== The psychological mechanism can be the most difficult aspect of the conversion diagnosis. DSM-IV requires that the clinician believe preceding stressors or conflicts to be associated with the development of the disorder, though ''how'' this might come about is still the subject of debate. The original Freudian model<ref>Josef Breuer & Sigmund Freud, "Studies in Hysteria", 1895</ref> suggested that the emotional charge of painful experiences would be consciously repressed as a way of managing the pain, but this emotional charge would be somehow 'converted' into the neurological symptoms. Freud later argued that the repressed experiences were of a sexual nature.<ref>Freud S, "Dora: Fragment of an analysis of a case of hysteria.", 1905</ref> Janet, the other great theoretician of hysteria, argued that symptoms arose through the power of suggestion, acting on a personality vulnerable to dissociation.<ref>Janet, P. "The Major Symptoms of Hysteria", 1920, 2nd Edition</ref> In this hypothetical process, the subject's experience of their leg, for example, is split-off from the rest of their consciousness, resulting in paralysis or numbness in that leg. Later authors have attempted to combine elements of these models, but none of them has a firm empirical basis.<ref>Brown, RJ. "Psychological mechanisms of medically unexplained symptoms: an integrative conceptual model." Psychol Bull. 2004 Sep;130(5):793-812.</ref> Some support for the Freudian model comes from findings of high rates of childhood sexual abuse in conversion patients<ref>Roelofs K, Keijsers GP, Hoogduin KA, Näring GW, Moene FC., "Childhood abuse in patients with conversion disorder." Am J Psychiatry. 2002 Nov;159(11):1908-13.</ref> and from a recent neuroimaging study showing abnormal emotion processing of a traumatic event linked to motor processing of the affected limb, in a patient with conversion.<ref>Kanaan RA, Craig TK, Wessely SC, David AS. "Imaging repressed memories in motor conversion disorder." Psychosom Med. 2007 Feb-Mar;69(2):202-5.</ref> Support for the dissociation model comes from studies showing heightened suggestibility in conversion patients,<ref>Roelofs K, Hoogduin KA, Keijsers GP, Näring GW, Moene FC, Sandijck P. "Hypnotic susceptibility in patients with conversion disorder." J Abnorm Psychol. 2002 May;111(2):390-5.</ref> and in abnormalities in motor imagery.<ref>Roelofs K, van Galen GP, Keijsers GP, Hoogduin CA. "Motor initiation and execution in patients with conversion paralysis." Acta Psychol (Amst). 2002 May;110(1):21-34.</ref> There has been much recent interest in functional neuroimaging in conversion. As researchers identify the mechanisms which underlie conversion symptoms it is hoped these will allow the development of a neuropsychological model. A number of such studies have been performed, including some which suggest that blood flow in patients brains may be abnormal while they are unwell. These have all been too small to be confident of the generalisability of their findings, however, so that no neuropsychological model has been clearly established. ==Epidemiology== ===Prevalence=== Information on the prevalence of conversion disorder in the West is limited, in part due to the complexities of the diagnostic process. In neurological settings, rates of unexplained symptoms are very high, at between 30 and 60%,<ref>Carson AJ, Ringbauer B, Stone J, McKenzie L, Warlow C, Sharpe M. "Do medically unexplained symptoms matter? A prospective cohort study of 300 new referrals to neurology outpatient clinics." J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):207-10.</ref><ref>Nimnuan C, Hotopf M, Wessely S. "Medically unexplained symptoms: an epidemiological study in seven specialities." J Psychosom Res. 2001 Jul;51(1):361-7.</ref><ref>Snijders TJ, de Leeuw FE, Klumpers UM, Kappelle LJ, van Gijn J. "Prevalence and predictors of unexplained neurological symptoms in an academic neurology outpatient clinic--an observational study." J Neurol. 2004 Jan;251(1):66-71.</ref>, which suggests conversion to be more common than most neurological diseases. However, the diagnosis of conversion typically requires an additional psychiatric evaluation, yet few patients will see a psychiatrist<ref>Crimlisk HL, Bhatia KP, Cope H, David AS, Marsden D, Ron MA. "Patterns of referral in patients with medically unexplained motor symptoms." J Psychosom Res. 2000 Sep;49(3):217-9.</ref> so an unknown fraction of those unexplained symptoms will be due to conversion. Large scale psychiatric registers in the US and Iceland found rates of 22 and 11 per 100000 per year, respectively,<ref>Stefánsson JG, Messina JA, Meyerowitz S. "Hysterical neurosis, conversion type: clinical and epidemiological considerations." [[Acta Psychiatrica Scandinavica]] 1976 Feb;53(2):119-38.</ref> but it is unclear what proportion of unexplained symptoms these represent. ===Culture=== It is often thought that rates are higher outside of the West, perhaps related to cultural and medical attitudes, though evidence for this is again limited.<ref>Akagi, H. & House, A.O., 2001, The epidemiology of hysterical conversion. In P. Halligan, C. Bass, J. Marshall (Eds.) Hysterical Conversion: clinical and theoretical perspectives (pp.73-87). Oxford: Oxford University Press.</ref> A community survey of urban Turkey found a rate of 5.6%.<ref>Deveci A, Taskin O, Dinc G, Yilmaz H, Demet MM, Erbay-Dundar P, Kaya E, Ozmen E. "Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, Turkey." Soc Psychiatry Psychiatr Epidemiol. 2007 Nov;42(11):857-64.</ref> Many authors have found rates to be higher in rural and lower socio-economic groups.<ref>Stefánsson JG, Messina JA, Meyerowitz S. "Hysterical neurosis, conversion type: clinical and epidemiological considerations." [[Acta Psychiatrica Scandinavica]] 1976 Feb;53(2):119-38.</ref><ref>Tomasson K, Kent D, Coryell W. "Somatization and conversion disorders: comorbidity and demographics at presentation." [[Acta Psychiatrica Scandinavica]] 1991 Sep;84(3):288-93.</ref><ref>Kuloglu M, Atmaca M, Tezcan E, Gecici O, Bulut S. "Sociodemographic and clinical characteristics of patients with conversion disorder in Eastern Turkey." Soc Psychiatry Psychiatr Epidemiol. 2003 Feb;38(2):88-93.</ref> ===Gender=== 'Hysteria' was originally understood to be a condition exclusively affecting women, though it has increasingly been recognised in men. In recent, larger studies,<ref>Deveci A, Taskin O, Dinc G, Yilmaz H, Demet MM, Erbay-Dundar P, Kaya E, Ozmen E. "Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, Turkey." Soc Psychiatry Psychiatr Epidemiol. 2007 Nov;42(11):857-64.</ref><ref>Carson AJ, Ringbauer B, Stone J, McKenzie L, Warlow C, Sharpe M. "Do medically unexplained symptoms matter? A prospective cohort study of 300 new referrals to neurology outpatient clinics." J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):207-10.</ref> women continue to predominate, with between 2 and 6 female patients for every male. ===Age=== Conversion disorder may present at any age but is rare in children younger than 10 years or in the elderly. Studies suggest a peak onset in the mid-to-late 30s <ref>Carson AJ, Ringbauer B, Stone J, McKenzie L, Warlow C, Sharpe M. "Do medically unexplained symptoms matter? A prospective cohort study of 300 new referrals to neurology outpatient clinics." J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):207-10.</ref><ref>Stefánsson JG, Messina JA, Meyerowitz S. "Hysterical neurosis, conversion type: clinical and epidemiological considerations." [[Acta Psychiatrica Scandinavica]] 1976 Feb;53(2):119-38.</ref><ref>Deveci A, Taskin O, Dinc G, Yilmaz H, Demet MM, Erbay-Dundar P, Kaya E, Ozmen E. "Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, Turkey." Soc Psychiatry Psychiatr Epidemiol. 2007 Nov;42(11):857-64.</ref>. == Treatment == Treatment may include the following<ref>Stone J, Carson A, Sharpe M. "Functional symptoms in neurology: management." J Neurol Neurosurg Psychiatry. 2005 Mar;76 Suppl 1:i13-21.</ref>: #Explanation. This must be clear and coherent. It must emphasise the genuineness of the condition, that it is common, potentially reversible and does not mean that the sufferer is a 'psycho'. Taking an aetiologically neutral stance by describing the symptoms as functional may be helpful but further studies are required. Ideally the patient should be followed up neurologically for a while to ensure that the diagnosis has been understood. #Physiotherapy where appropriate; #Treatment of comorbid depression or anxiety if present. There is little evidence-based treatment of conversion disorder.<ref>Ruddy and House, Cochrane Collaboration</ref> Other treatments such as [[cognitive behavioral therapy]], [[hypnosis]], [[EMDR]], and [[psychodynamic psychotherapy]] need further trials. ==References== {{Reflist|2}} Reference (3): Introductory Lectures on Psychoanalysis, Freud, p,497-98, W.W. Norton, 1966 [[el:Διαταραχή μετατροπής]] [[es:Trastorno de conversión]] [[nl:Conversiestoornis]] [[pl:Dysocjacja (psychologia)]]