Croup 310898 223810042 2008-07-05T22:39:08Z Hcaandersen 2829216 {{dablink|This term also refers to the rump of a quadruped; see [[wikt:croup|croup]] (Wiktionary). For the work of a casino employee, see [[croupier]].}} {{Infobox_Disease | Name = Croup | Image = | Caption = | DiseasesDB = 13233 | ICD10 = {{ICD10|J|05|0|j|00}} | ICD9 = {{ICD9|464.4}} | ICDO = | OMIM = | MedlinePlus = 000959 | eMedicineSubj = ped | eMedicineTopic = 510 | eMedicine_mult = {{eMedicine2|emerg|370}} {{eMedicine2|radio|199}} | MeshID = D003440 }} '''Croup''' is a group of [[respiratory disease]]s that often affect infants and children under age 6. It is characterized by a barking cough; a whistling, obstructive sound ([[stridor]]) as the child breathes in; and hoarseness due to obstruction in the region of the larynx. It may be mild, moderate or severe, and severe cases, with breathing difficulty, can be fatal if not treated in a hospital.<ref name="Cherry08_NEJM">[http://content.nejm.org/cgi/content/full/358/4/384 James D. Cherry, Clinical practice: Croup, New England Journal of Medicine, 24 Jan 2008, 358(4):384]</ref> Croup affects 5% of children in the second year of life; the peak incidence is between 7 and 36 months. The group of respiratory diseases consists of spasmotic croup, acute laryngotracheitis, laryngotracheobronchitis (LTB), laryngotracheobronchopneumitis (LTBP), and laryngeal diptheria. LTB and LTBP, which usually involve a bacterial infection, are usually severe.<ref name="Cherry08_NEJM"/> The first step in diagnosis is to exclude other acute obstructive illnesses in the region of the larynx, such as epiglottitis, a foreign body, or angioneurotic edema of the epiglottis. Misdiagnosing an obstructive airway disease can be fatal.<ref name="Cherry08_NEJM"/> The Alberta Clinical Practice Guideline Working Group has developed guidelines for diagnosing and treating croup, including a scoring system for classifying severity.<ref>[http://www.topalbertadoctors.org/NR/rdonlyres/B072F5EF-1728-4BED-A88A-68A99341B98A/0/croup_guideline.pdf Guideline for the Diagnosis and Management of Croup], Administered by the Alberta Medical Association, 2007 Update</ref> The severe form (which affected less than 1% of children seen in the emergency department) involves breathing difficulties, indicated by stridor, chest retractions, agitation and distress. Lethargy or decreased level of consciousness is a sign of impending respiratory failure, and requires emergency medical treatment. LTB and LTBP are usually severe, and require treatment in the intensive care unit, with a throat tube to assist breathing, and antibiotics.<ref name="Cherry08_NEJM"/> The routinely recommended treatment is with corticosteroids, although corticosteroids suppress the immune system and can predispose the child towards infection. There is a debate over how many doses to give, but Cherry in the New England Journal of Medicine recommends one dose, and has observed that children with viral, bacterial and fungal complications have had multiple doses. Epinephrine produces a significant reduction in the croup severity score but the benefit only lasts for 2 hours. Children who have moderate or severe croup with blood oxygen saturation under 92% should receive oxygen.<ref name="Cherry08_NEJM"/> Since laryngotracheitis is a viral disease (most commonly [[Human parainfluenza viruses|parainfluenza virus 1]]) antibiotics have no value. Croup can be prevented by immunization for influenza and diphtheria. At one time, croup referred to a diphtherial disease, but with vaccination diphtheria is rare.<ref name="Cherry08_NEJM"/> ==Signs and symptoms== Croup is characterized by a harsh "barking" cough and sneeze, inspiratory [[stridor]] (a high-pitched sound heard on inhalation), nausea/[[vomiting]], and [[fever]]. Hoarseness is usually present. More severe cases will have [[respiratory distress]]. The "barking" cough (often described as a "seal like bark")<ref> {{cite web |url=http://www.lpch.org/diseasehealthinfo/healthlibrary/respire/croup.html |date=2007-01-05 |title=Croup - Lucile Packard Children's Hospital}}</ref> of croup is diagnostic. [[Stridor]] will be provoked or worsened by agitation or [[crying]]. If stridor is also heard when the child is calm, critical narrowing of the airway may be imminent. In diagnosing croup, it is important for the [[physician]] to consider and exclude other causes of shortness of breath and stridor, such as [[foreign body]] aspiration and [[epiglottitis]]. On a [[frontal]] [[X-ray]] of the [[C-spine]], the [[steeple sign]] suggests the diagnosis of croup. ==Causes== Croup is most often caused by [[parainfluenza]] [[virus]], primarily types 1 and 2, but other viral and possibly [[bacterium|bacteria]]l infections can also cause it. It is most common in the fall and winter but can occur year-round, with a slight predilection for males. The respiratory distress is caused by the inflammatory response to the infection, rather than by the infection itself. It usually occurs in young children as their airways are smaller and differently shaped than adults', making them more susceptible. There is some element of genetic [[predisposition]] as children in some families are more susceptible than others. An entity known as '''spasmodic croup''' also occurs, distinct from the infectious variety, due to [[laryngospasm|laryngeal spasms]]. ==Treatment== The treatment of croup depends on the severity of symptoms. One of the traditional ways to treat croup is to inhale hot steam. However, studies have found that this is not effective.<ref name="Cherry08_NEJM"/> This was the sole treatment for croup throughout the nineteenth and most of the twentieth century.{{Fact|date=March 2008}} [[Hospital]]s today use a "blowby" apparatus for this purpose. Simpler remedies include taking the child outside in moist night air, or alternatively exposing the child to steam from a hot bath or a humidifier. There is little or no evidence to support their efficacy. Mild croup with no [[stridor]], or stridor only on agitation, and just a cough may simply be observed, or a dose of inhaled, oral, or injected [[steroids]] may be given. When steroids are given, [[dexamethasone]] is often used, due to its prolonged physiologic effects. Moderate to severe croup may require [[nebulizer|nebulized]] [[adrenaline]] in addition to steroids. [[Oxygen]] may be needed if [[Hypoxia (medical)|hypoxia]] develops. Children with moderate or severe croup are typically hospitalized for observation, usually for less than a day. [[Intubation]] is rarely needed (less than 1% of hospitalized patients). ==Prognosis== Viral croup is a [[Self-limiting|self-limited]] disease, but can very rarely result in death from complete airway obstruction. Symptoms may last up to 7 days, but typically peak around the second day of illness. Rarely, croup can be complicated by (or confused with) an acute bacterial [[tracheitis]], which is more dangerous. ==References== <references/> ==External links== * [http://www.mayoclinic.com/health/croup/DS00312 MayoClinic] * Four kinds of croup http://www.healthscout.com/ency/68/135/main.html {{Respiratory pathology}} {{Common Cold}} [[Category:Pediatrics]] [[Category:Pulmonology|Croup]] [[Category:Viruses|Croup]] [[de:Pseudokrupp]] [[es:Laringotraqueobronquitis]] [[it:Croup]] [[nl:Pseudokroep]] [[ja:クループ]] [[no:Falsk krupp]] [[nn:Falsk krupp]] [[ru:Круп]]