Cyclin E
5629262
191367305
2008-02-14T06:41:29Z
67.84.102.227
{{protein
|Name=[[CCNE1|cyclin E1]]
|caption=
|image=
|width=
|HGNCid=1589
|Symbol=[[CCNE1]]
|AltSymbols=CCNE
|EntrezGene=898
|OMIM=123837
|RefSeq=NM_001238
|UniProt=P24864
|PDB=
|ECnumber=
|Chromosome=19
|Arm=q
|Band=12
|LocusSupplementaryData=
}}
{{protein
|Name=[[CCNE2|cyclin E2]]
|caption=
|image=
|width=
|HGNCid=1590
|Symbol=[[CCNE2]]
|AltSymbols=
|EntrezGene=9134
|OMIM=603775
|RefSeq=NM_057749
|UniProt=O96020
|PDB=
|ECnumber=
|Chromosome=8
|Arm=q
|Band=22.1
|LocusSupplementaryData=
}}
'''Cyclin E''' is a member of the [[cyclin]] family.
Cyclin E binds to G<sub>1</sub> phase Cdk2, which is required for the transition from G<sub>1</sub> to S phase. The Cyclin E/CDK2 complex phosphorylates p27<sup>Kip1</sup> (an inhibitor of Cyclin D), tagging it for degradation, thus promoting expression of Cyclin A, allowing progression to S phase.
[[Image:Cyclinexpression waehrend Zellzyklus.png|center|422px|Expression of cyclins through the [[cell cycle]].]]
==External links==
* {{MeshName|Cyclin+E}}
{{Cell-biology-stub}}
{{Cell cycle proteins}}
[[Category:Cell cycle]]
[[Category:Proteins]]