Cyclin E 5629262 191367305 2008-02-14T06:41:29Z 67.84.102.227 {{protein |Name=[[CCNE1|cyclin E1]] |caption= |image= |width= |HGNCid=1589 |Symbol=[[CCNE1]] |AltSymbols=CCNE |EntrezGene=898 |OMIM=123837 |RefSeq=NM_001238 |UniProt=P24864 |PDB= |ECnumber= |Chromosome=19 |Arm=q |Band=12 |LocusSupplementaryData= }} {{protein |Name=[[CCNE2|cyclin E2]] |caption= |image= |width= |HGNCid=1590 |Symbol=[[CCNE2]] |AltSymbols= |EntrezGene=9134 |OMIM=603775 |RefSeq=NM_057749 |UniProt=O96020 |PDB= |ECnumber= |Chromosome=8 |Arm=q |Band=22.1 |LocusSupplementaryData= }} '''Cyclin E''' is a member of the [[cyclin]] family. Cyclin E binds to G<sub>1</sub> phase Cdk2, which is required for the transition from G<sub>1</sub> to S phase. The Cyclin E/CDK2 complex phosphorylates p27<sup>Kip1</sup> (an inhibitor of Cyclin D), tagging it for degradation, thus promoting expression of Cyclin A, allowing progression to S phase. [[Image:Cyclinexpression waehrend Zellzyklus.png|center|422px|Expression of cyclins through the [[cell cycle]].]] ==External links== * {{MeshName|Cyclin+E}} {{Cell-biology-stub}} {{Cell cycle proteins}} [[Category:Cell cycle]] [[Category:Proteins]]