Cysteine dioxygenase
1484644
223166516
2008-07-02T21:23:31Z
Sergitoc
7374074
{{protein
|Name=cysteine dioxygenase, type I
|caption=
|image=
|width=
|HGNCid=1795
|Symbol=CDO1
|AltSymbols=
|EntrezGene=1036
|OMIM=603943
|RefSeq=NM_001801
|UniProt=Q16878
|PDB=
|ECnumber=1.13.11.20
|Chromosome=5
|Arm=q
|Band=23.2
|LocusSupplementaryData=
}}
'''Cysteine dioxygenase''' (CDO,[[CAS number]]: 37256-59-0)) is a [[mammalian]] non-[[heme]] iron [[enzyme]] that [[catalyze]]s the conversion of L-[[cysteine]] to [[cysteine sulfinic acid]] (cysteine sulfinate) by incorporation of [[dioxygen]].
[[Image:Cysteine-dioxygenase-reaction.png|frame|none|''CDO reaction scheme showing cysteine sulfinic acid formation from cysteine by dioxygen incorporation'']]
Cysteine sulfinic acid lies at a branch-point in [[cysteine catabolism]], where it can follow two pathways resulting in the formation of [[taurine]] or [[sulfate]]. The cysteine sulfinic acid dependent pathway of taurine metabolism follows the synthesis of [[hypotaurine]] ([[2-aminoethane sulfinate]]), which is subsequently oxidized to taurine. Alternatively, cysteine sulfinate can undergo transamination to form [[β-sulfinylpyruvate]], decomposing to form [[pyruvate]] and [[sulfite]].
{{1.13-enzyme-stub}}
{{Monooxygenases}}
[[Category:enzymes]]
[[Category:EC 1.13.11]]
References
1. Sakakibara S, Yamaguchi K, Hosokawa Y, Kohashi N, Ueda I. Purification and some properties of rat liver cysteine oxidase (cysteine dioxygenase).Biochim Biophys Acta. 1976 Feb 13;422(2):273-9
2. Chai SC, Jerkins AA, Banik JJ, Shalev I, Pinkham JL, Uden PC, Maroney MJ. Heterologous expression, purification, and characterization of recombinant rat cysteine dioxygenase.
J Biol Chem. 2005 Mar 18;280(11):9865-9.
3. McCoy JG, Bailey LJ, Bitto E, Bingman CA, Aceti DJ, Fox BG, Phillips GN Jr. Structure and mechanism of mouse cysteine dioxygenase. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3084-9.