Cysteine dioxygenase 1484644 223166516 2008-07-02T21:23:31Z Sergitoc 7374074 {{protein |Name=cysteine dioxygenase, type I |caption= |image= |width= |HGNCid=1795 |Symbol=CDO1 |AltSymbols= |EntrezGene=1036 |OMIM=603943 |RefSeq=NM_001801 |UniProt=Q16878 |PDB= |ECnumber=1.13.11.20 |Chromosome=5 |Arm=q |Band=23.2 |LocusSupplementaryData= }} '''Cysteine dioxygenase''' (CDO,[[CAS number]]: 37256-59-0)) is a [[mammalian]] non-[[heme]] iron [[enzyme]] that [[catalyze]]s the conversion of L-[[cysteine]] to [[cysteine sulfinic acid]] (cysteine sulfinate) by incorporation of [[dioxygen]]. [[Image:Cysteine-dioxygenase-reaction.png|frame|none|''CDO reaction scheme showing cysteine sulfinic acid formation from cysteine by dioxygen incorporation'']] Cysteine sulfinic acid lies at a branch-point in [[cysteine catabolism]], where it can follow two pathways resulting in the formation of [[taurine]] or [[sulfate]]. The cysteine sulfinic acid dependent pathway of taurine metabolism follows the synthesis of [[hypotaurine]] ([[2-aminoethane sulfinate]]), which is subsequently oxidized to taurine. Alternatively, cysteine sulfinate can undergo transamination to form [[β-sulfinylpyruvate]], decomposing to form [[pyruvate]] and [[sulfite]]. {{1.13-enzyme-stub}} {{Monooxygenases}} [[Category:enzymes]] [[Category:EC 1.13.11]] References 1. Sakakibara S, Yamaguchi K, Hosokawa Y, Kohashi N, Ueda I. Purification and some properties of rat liver cysteine oxidase (cysteine dioxygenase).Biochim Biophys Acta. 1976 Feb 13;422(2):273-9 2. Chai SC, Jerkins AA, Banik JJ, Shalev I, Pinkham JL, Uden PC, Maroney MJ. Heterologous expression, purification, and characterization of recombinant rat cysteine dioxygenase. J Biol Chem. 2005 Mar 18;280(11):9865-9. 3. McCoy JG, Bailey LJ, Bitto E, Bingman CA, Aceti DJ, Fox BG, Phillips GN Jr. Structure and mechanism of mouse cysteine dioxygenase. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3084-9.