DNA glycosylase
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LostLucidity
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Wikified 8-oxoguanine
'''DNA glycosylases''' are a family of [[enzyme]]s involved in [[base excision repair]], classified under [[EC number]] EC 3.2.2. Base excision repair is the mechanism by which [[nucleotide]] residues in [[DNA]] with chemically altered nitrogen bases can be removed and replaced.
DNA glycosylase generates an apurinic or apyrimidinic site by removing the nitrogen base while leaving the sugar-phosphate backbone intact. These [[AP site]]s are recognised by [[AP endonuclease]] [[enzymes]] which complete the rest of the repair.
Some examples of DNA glycosylases:
* Ogg1 (yeast) or hOgg1 (humans) which removes [[8-oxoguanine]], a type of modified nucleotide typically found after DNA is exposed to oxidative mutagens. See also [[OGG1]].
* uracil-DNA glycosylase, found in prokaryotes and eukaryotes, which removes uracil from DNA.
==References==
* Griffiths, Anthony J. et al (2005). ''Introduction to Genetic Analysis (8th Ed.)''. W.H. Freeman. ISBN 0-7167-4939-4
==External links==
* {{MeshName|DNA+Glycosylases}}
{{enzyme-stub}}
{{Sugar hydrolases}}
[[Category:DNA repair]]
[[Category:Enzymes]]
[[de:Glykosilase]]
[[fr:Glycosylase]]
[[ja:DNAグリコシラーゼ]]