Demecarium bromide
4959031
215575962
2008-05-28T20:25:46Z
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{{drugbox
| IUPAC_name = trimethyl-[3-[methyl-[10-[methyl- (3-trimethylammoniophenoxy) carbonyl-amino] decyl] carbamoyl] oxyphenyl]-ammonium dibromide
| image = Demecarium bromide.png
| CAS_number = 56-94-0
| ATC_prefix = S01
| ATC_suffix = EB04
| ATC_supplemental =
| PubChem = 5965
| DrugBank = APRD00905
| C=32 | H=52 | Br=2 | N=4 | O=4
| molecular_weight = 716.588 g/mol
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
| legal_UK = <!-- GSL / P / POM / CD -->
| legal_US = <!-- OTC / Rx-only -->
| legal_status =
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{{context}}
'''Demecarium bromide''' is a compound classified by the [[World Health Organization]] as a [[parasympathomimetic]].{{Fact|date=February 2007}} Demecarium bromide is one of several topical (applied directly to the affected area) medications used to reduce elevated intraocular pressure (IOP) associated with primary glaucoma in cats, dogs, and other animals.
==See also==
* [[Diisopropylfluorophosphate]]
* [[Intraocular pressure]]
* [[Glaucoma]]
==External links==
* {{cite journal | author = Ward D, Abney K, Oliver J | title = The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs. | journal = Vet Ophthalmol | volume = 6 | issue = 1 | pages = 23–5 | year = 2003 | pmid = 12641839 | doi = 10.1046/j.1463-5224.2003.00257.x}}
* {{cite journal | author = Krohne S | title = Effect of topically applied 2% pilocarpine and 0.25% demecarium bromide on blood-aqueous barrier permeability in dogs. | journal = Am J Vet Res | volume = 55 | issue = 12 | pages = 1729–33 | year = 1994 | pmid = 7887518}}
* {{cite journal | author = Gum G, Gelatt K, Gelatt J, Jones R | title = Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. | journal = Am J Vet Res | volume = 54 | issue = 2 | pages = 287–93 | year = 1993 | pmid = 8430939}}
{{Antiglaucoma preparations and miotics}}
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