Diacerein 3337178 221301380 2008-06-23T22:45:09Z Rjwilmsi 203434 gen fixes + format *date= in cite templates - full explanation [[User:Rjwilmsi#My_correction_of_dates_in_templates|here]] using [[Project:AutoWikiBrowser|AWB]] {{drugbox | IUPAC_name = 4,5-diacetyloxy-9,10-dioxo-anthracene-2-<br>carboxylic&nbsp;acid | image = Diacerein.svg | CAS_number = 13739-02-1 | ATC_prefix = M01 | ATC_suffix = AX21 | PubChem = 26248 | DrugBank = | synonyms = Diacetylrhein, diacerhein | C=19|H=12|O=8 | molecular_weight = 368.294 g/mol | bioavailability = | protein_bound = 99% | metabolism = [[Liver|Hepatic]]: [[acetylation|deacetylation]] to [[rhein]], later [[glucuronidation]] and [[sulfate]] conjugation | elimination_half-life = 4 to 5 hours | excretion = [[Kidney|Renal]] (30%) | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_US = <!-- A / B / C / D / X --> | pregnancy_category= Lacking information | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | legal_status = | routes_of_administration = Oral }} '''Diacerein''' ([[International Nonproprietary Name|INN]]), also known as '''diacetylrhein''', is a drug used in the treatment of [[osteoarthritis]]. It works by inhibiting [[interleukin-1]]. A 2005 [[Cochrane Collaboration|Cochrane]] [[systematic review|review]] found diacerein to be slightly, but [[statistical significance|significantly]], more effective than placebo in controlling the pain of osteoarthritis.<ref name="Cochrane">{{cite journal |author=Fidelix TS, Soares BG, Trevisani VF |title=Diacerein for osteoarthritis |journal=[[Cochrane Library|Cochrane database of systematic reviews (Online)]] |volume= |issue=1 |pages=CD005117 |year=2006 |pmid=16437519 |doi=10.1002/14651858.CD005117.pub2}} [http://www.cochrane.org/reviews/en/ab005117.html Free summary]</ref> ==Side effects== The most common [[adverse drug reaction|side effects]] of diacerein treatment are [[gastrointestinal tract|gastrointestinal]], such as [[diarrhea]].<ref name="Cochrane"/><ref>{{fr icon}} {{cite web | url = http://www.biam2.org/www/Sub5020.html | title = Diacereine | accessdate = 2007-06-13 | date = 1999-03-24 | publisher = BIAM}}</ref> ==References== {{Reflist}} {{Anti-inflammatory and antirheumatic products}} [[Category:Anti-inflammatory agents]] {{pharma-stub}}