Diazoxide 1612851 203761544 2008-04-06T15:07:20Z BodhisattvaBot 6228552 robot Adding: [[it:Diazossido]] {{drugbox | IUPAC_name = 7-chloro-3-methyl-4''H''-1,2,4-benzothiadiazine 1,1-dioxide | image = Diazoxide.svg | CAS_number = 364-98-7 | ATC_prefix = C02 | ATC_suffix = DA01 | ATC_supplemental = {{ATC|V03|AH01}} | PubChem = 3019 | DrugBank = APRD00914 | C = 8 | H = 7 | Cl = 1 | N = 2 | O = 2 | S = 1 | molecular_weight = 230.672 g/mol | bioavailability = | protein_bound = 90% | metabolism = [[Liver|Hepatic]] [[oxidation]] and [[sulfate]] conjugation | elimination_half-life = 21-45 hours | excretion = [[Kidney|Renal]] | pregnancy_AU = C | pregnancy_US = C | legal_UK = POM | legal_US = Rx-only | routes_of_administration = Oral, [[Intravenous therapy|intravenous]] }} '''Diazoxide''' is a [[potassium channel]] activator, which causes local relaxation in [[smooth muscle]] by increasing membrane [[Semipermeable membrane|permeability]] to potassium [[ion]]s. This switches off voltage-gated [[calcium]] ion channels which inhibits the generation of an [[action potential]]. It is used as a [[vasodilator]] in the treatment of acute [[hypertension]], and also to decrease the secretion of [[insulin]] in disease states such as [[insulinoma]] (a tumor producing insulin). {{pharma-stub}} {{Antihypertensives and diuretics}} [[Category:Sulfonamides]] [[Category:Vasodilators]] [[de:Diazoxid]] [[fr:Diazoxide]] [[hr:Diazoksid]] [[it:Diazossido]]