Dorothy Crowfoot Hodgkin
105825
226047339
2008-07-16T16:21:56Z
Emerson7
191157
copyediting; cleanup
{{Infobox Scientist
| name = Dorothy Crowfoot Hodgkin
| image = Old Dorothy Hodgkin from Pugwash site.jpg
| imagesize = 180px
| caption = Dorothy Hodgkin with a ball-stick representation of insulin
| birth_date = [[May 12]], [[1910]]
| birth_place = [[Cairo]], [[Egypt]]
| death_date = {{death date and age|1994|07|29|1910|05|12}}
| death_place =
| nationality = [[United Kingdom]]
| field = [[Biochemistry]]
| work_institution =
| alma_mater = [[Somerville College, Oxford]]<br />[[University of Cambridge]]
| doctoral_advisor = [[John Desmond Bernal]]
| doctoral_students =
| known_for = discovery of [[protein crystallography]]
| prizes = [[Nobel Prize in Chemistry]] (1964)
}}
'''Dorothy Mary Hodgkin''', [[Order of Merit (Commonwealth)|OM]], [[Fellow of the Royal Society|FRS]] ([[12 May]] [[1910]] – [[29 July]] [[1994]]) was a British chemisty, credited with the discovery of [[protein crystallography]]
She pioneered the technique of [[X-ray crystallography]], a method used to determine the three dimensional structures of biomolecules. Among her most influential discoveries are the determination of the structure of [[penicillin]] and [[vitamin B12]], for which she was awarded the [[Nobel Prize in Chemistry]]. In 1969, after 35 years of work and five years after winning the [[Nobel Prize in Chemistry]], Hodgkin was able to decipher the structure of insulin. She is regarded as one of the foremost scientists in the field of X-Ray crystallography studies of natural molecules. Besides her extraordinary scientific abilities, she was unassuming, very communicative, and passionate about social inequalities and peace.
==Timeline of her discoveries==
Hodgkin determined the three-dimensional structures of the following biomolecules:
* [[cholesterol]] in 1937
* [[penicillin]] in 1945
* [[vitamin B12]] in 1954
* [[insulin]] in 1969
* as well as [[lactoglobulin]], [[ferritin]], and [[tobacco mosaic virus]]
The list is not exhaustive, it rather highlights major milestones.
==Early years==
She was born Dorothy Mary Crowfoot in [[May 12]], [[1910]] in [[Cairo]], [[Egypt]], to John Crowfoot, excavator and scholar of classics, and Grace Mary Crowfoot ''née'' Hood. For the first four years of her life she lived as an English expatriate in Asia Minor, returning to England only a few months each year. She spent the period of [[World War I]] in the UK under the care of relatives and friends, but separated from her parents. After the war, her mother decided to stay home in England and educate her children, a period that Hodgkin later described as the happiest in her life.
In 1921, she entered the Sir [[John Leman]] Grammar School in [[Beccles]], [[Suffolk]]. She traveled abroad frequently to visit her parents in Cairo and [[Khartoum]]. Both her father and her mother had a strong influence with their [[Puritan]] ethic of selflessness and service to humanity which reverberated in her later achievements.
==Education and research==
She developed a passion for chemistry from a young age, and her mother fostered her interest in science in general. Her excellent early education prepared her well for university. At age 18 she started studying [[chemistry]] at [[Somerville College, Oxford]], then one of the [[University of Oxford]] colleges for women only.
She also studied at the [[University of Cambridge]] under the tutelage of [[John Desmond Bernal]], where she became aware of the potential of X-ray crystallography to determine the structure of [[proteins]].
In 1934, she moved back to Oxford and two years later, in 1936, she became a research fellow at Somerville College, a post which she held until 1977. In 1960 she was appointed Wolfson Research Professor at the [[Royal Society]].
==Insulin structure==
[[Insulin]] was one of her most extraordinary research projects. It began in 1934 when she was offered a small sample of crystalline insulin by [[Robert Robinson (scientist)|Robert Robinson]]. The [[hormone]] captured her imagination because of the intricate and wide-ranging effect it has in the body. However, at this stage X-ray crystallography had not been developed far enough to cope with the complexity of the insulin molecule. She and others spent many years improving the technique. Larger and more complex molecules were being tackled (see timeline above) until in 1969 - 35 years later - the structure of insulin was finally resolved. But her quest was not finished then. She cooperated with other laboratories active in insulin research, gave advice, and travelled the world giving talks about insulin and its importance for [[diabetes]]. She considered solving the structure of insulin her greatest scientific achievement.
==Private life==
Hodgkin's scientific mentor [[John Desmond Bernal|J.D. Bernal]] greatly influenced her life both scientifically and politically. He was a distinguished scientist of great repute in the scientific world, a member of the [[Communist]] party, and a faithful supporter of successive [[Soviet]] regimes until their [[1956 Hungarian Revolution|invasion of Hungary]]. She always referred to him as "Sage" and loved and admired him unreservedly; intermittently, they were lovers. The conventional marriages of both Bernal and Hodgkin were far from smooth.
In 1937, Dorothy married Thomas Hodgkin who was also a one-time member of the Communist party, as well as a charming, intelligent, energetic and impulsive suitor. She also loved him and always consulted him concerning important problems and decisions. Dorothy bore quietly the many difficulties of these situations. He later had a varied career as a schoolteacher, worker's educationist, historian and economist. He became an advisor in 1961 to [[Kwame Nkrumah]], President of [[Ghana]], where he remained for extended periods, often visited by her. The couple had three children. All three children are still alive today. One has a girl named Alexandra Dorothy after their grandmother.
==Social activities==
Despite her scientific specialisation and excellence she was by no means a single-minded and one-sided scientist. She received many honours but was more interested in exchange with other scientists. She often employed her intelligence to think about other people's problems and was concerned about social inequalities and stopping conflict. As a consequence she was President of Pugwash from 1976 to 1988.
==Honours==
[[Image:Order of Merit Dorothy Hodgkin.jpg|200px|thumb|[[Order of Merit]] medal of Dorothy Crowfoot Hodgkin, displayed in the Royal Society, London.]]
Apart from the Nobel Prize, she was a recipient of the [[Order of Merit]], a [[Fellow#General academic use|Fellow]] of the [[Royal Society]], The [[Lenin Peace Prize]], and was [[Chancellor (education)|Chancellor]] of [[University of Bristol|Bristol University]] from 1970 to 1988.
Council offices in the [[London Borough of Hackney]] are named Dorothy Hodgkin House.
==References==
*Ferry, Georgina. 1998. ''Dorothy Hodgkin A Life''. Granta Books, London.
*Dodson, Guy. 2002. ''Dorothy Mary Hodgkin, OM''. Biographical Memoir, The Royal Society, London.
*Dodson, Guy, Jenny P. Glusker, and David Sayre (eds.). 1981. ''Structural Studies on Molecules of Biological Interest: A Volume in Honour of Professor Dorothy Hodgkin''. Oxford: The Clarendon Press.
*Glusker, Jenny P. in [http://www.cambridge.org/us/catalogue/catalogue.asp?isbn=9780521821971 Out of the Shadows] - Contributions of 20th Century Women to Physics.
*{{cite journal | title=Dorothy Crowfoot Hodgkin (1910-1994) | author=Glusker, Jenny P. | journal= Protein Science | volume=3 | issue= | pages=2465–2469 | year=1994 | url=http://protsci.highwire.org/cgi/reprint/3/12/2465 | doi=}}
*{{cite journal | title=Dorothy Crowfoot Hodgkin | author=Glusker, Jenny P., Margaret J. Adams | journal= Physics Today | volume=48 | issue= | pages=80–81 | year=1995 | url= | doi=10.1063/1.2808036}}
*{{cite journal | title=Professor Dorothy Hodgkin, OM, FRS | author=Louise N. Johnson, David Phillips | journal= Nature Structural & Molecular Biology | volume=1 | issue= | pages=573–576 | year=1994 | url=http://www.nature.com/nsmb/journal/v1/n9/pdf/nsb0994-573.pdf | doi=}}
*Perutz, Max F. (''Quarterly Review of Biophysics'' 27: 333-337, 1994)
*''Nature'' 371: 20, 1994.
*[http://www.royalsoced.org.uk/fellowship/obits/obits_alpha/hodgkin_dorothy.pdf Royal Society of Edinburgh obituary]
*{{cite journal | title=Dorothy Mary Crowfoot Hodgkin, O.M. 12 May 1910--29 July 1994 | author=Guy Dodson | journal= Biographical Memoirs of Fellows of the Royal Society | volume=48 | issue= | pages=179–219 | year=2002 | url=http://links.jstor.org/sici?sici=0080-4606%28200212%2948%3C179%3ADMCHO1%3E2.0.CO%3B2-I | doi=}}
==External links==
*[http://cwp.library.ucla.edu/Phase2/Hodgkin,_Dorothy_Crowfoot@841234567.html CWP] - Dorothy Hodgkin in a study of contributions of women to physics
*[http://www.pugwash.org/reports/pim/hodgkin.htm Review of Ferry's biography on the Pugwash website]
*[http://www.britannica.com/eb/article-9040680/Dorothy-Crowfoot-Hodgkin Encyclopaedia Britannica, Dorothy Crowfoot Hodgkin]
*[http://www.sdsc.edu/ScienceWomen/hodgkin.html Dorothy Crowfoot Hodgkin: A Founder of Protein Crystallography]
*[http://nobelprize.org/chemistry/laureates/1964/index.html Nobel Prize 1964 page]
*[http://uk.geocities.com/hertouyt/milko/hodgkin-speech.html Her determinations by X-ray techniques of the structures of important biochemical substances.]
*[http://www.rcuk.ac.uk/hodgkin/default.htm Dorothy Hodgkin Postgraduate Awards]
{{start box}}
{{s-aca}}
{{succession box|title=[[Chancellor (education)|Chancellor]] of the [[University of Bristol]]|before=[[Henry Somerset, 10th Duke of Beaufort|The Duke of Beaufort]]|after=[[Sir Jeremy Morse]]|years=1970-1988}}
{{end box}}
{{Nobel Prize in Chemistry Laureates 1951-1975}}
{{Persondata
|NAME= Hodgkin, Dorothy Mary Crowfoot
|ALTERNATIVE NAMES= Crowfoot, Dorothy Mary
|SHORT DESCRIPTION= Medical scientist
|DATE OF BIRTH= [[12 May]] [[1910]]
|PLACE OF BIRTH= [[Cairo]], [[Egypt]]
|DATE OF DEATH= [[1994-07-29]]
|PLACE OF DEATH= [[Ilmington]], [[Warwickshire]], [[England]]
}}
{{DEFAULTSORT:Hodgkin, Dorothy Crowfoot}}
[[Category:1910 births]]
[[Category:1994 deaths]]
[[Category:Alumni of Somerville College, Oxford]]
[[Category:British biochemists]]
[[Category:Chancellors of the University of Bristol]]
[[Category:Crystallography]]
[[Category:Fellows of the Royal Society]]
[[Category:Members of the Order of Merit]]
[[Category:Nobel laureates in Chemistry]]
[[Category:People from Beccles]]
[[Category:People from Cairo]]
[[Category:Recipients of the Copley Medal]]
[[Category:Women chemists]]
[[af:Dorothy Crowfoot Hodgkin]]
[[ar:دوروثي كراوفوت هودجكن]]
[[ca:Dorothy Crowfoot Hodgkin]]
[[cs:Dorothy Crowfoot Hodgkin]]
[[de:Dorothy Mary Hodgkin]]
[[et:Dorothy Crowfoot Hodgkin]]
[[es:Dorothy Crowfoot Hodgkin]]
[[fr:Dorothy Crowfoot Hodgkin]]
[[gl:Dorothy Crowfoot]]
[[io:Dorothy Crowfoot Hodgkin]]
[[id:Dorothy Crowfoot Hodgkin]]
[[it:Dorothy Crowfoot Hodgkin]]
[[sw:Dorothy Hodgkin]]
[[lv:Dorotija Kraufuta Hodžkina]]
[[nl:Dorothy Crowfoot Hodgkin]]
[[ja:ドロシー・ホジキン]]
[[oc:Dorothy Crowfoot Hodgkin]]
[[pl:Dorothy Crowfoot Hodgkin]]
[[pt:Dorothy Crowfoot Hodgkin]]
[[ro:Dorothy Crowfoot Hodgkin]]
[[sq:Dorothy Crowfoot Hodgkin]]
[[sk:Dorothy Mary Hodgkinová]]
[[sl:Dorothy Crowfoot Hodgkin]]
[[sr:Дороти Кроуфут Хоџкин]]
[[fi:Dorothy Crowfoot Hodgkin]]
[[sv:Dorothy Crowfoot Hodgkin]]
[[tr:Dorothy Crowfoot Hodgkin]]
[[zh:多萝西·克劳福特·霍奇金]]