Duck hepatitis B virus 4296853 221228546 2008-06-23T16:47:41Z Iridescent 937705 Cleanup/[[WP:AWB/T|typo fixing]], typos fixed: and and → and using [[Project:AutoWikiBrowser|AWB]] {{Taxobox | virus_group = vii | familia = '''''Hepadnaviridae''''' | genus = ''[[Avihepadnavirus]]'' }} '''Duck Hepatitis B virus''', DHBV, is part of the [[Avihepadnavirus]] genus of the [[Hepadnaviridae]], and is the causal agent of duck hepatitis B. DHBV is a small [[DNA virus]] with a diameter of 40-45nm. The viral envelope is made up from host cell lipid, with viral surface antigens (DHBsAg). The icosahedral nuclocapsid within, is composed of the virus core antigen (DHBcAg) and surrounds the DNA genome and viral polymerase. The viral genome is a circular double stranded DNA molecule about 3000 base pairs long. The genome has three overlapping open reading frames or ORFs: * C-ORF – encoding the core antigen and pre-core protein which are processed and secreted as DHBcAg * S-ORF – codes for the surface antigen DHBsAg * P-ORF – encoding the viral polymerase. On binding and [[viral entry|entry]] of the virus to the host cell, the genome is transported to the nucleus to be transcribed. Novel viral RNA is then transferred to the cytoplasm for translation and subsequent protein synthesis. == External links == *Jilbert AR, Kotlarski I Immune responses to duck hepatitis B virus infection. Dev Comp Immunol. 2000 Mar-Apr;24(2-3):285-302.[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10717294&query_hl=1&itool=pubmed_DocSum] *Cooper A, Paran N, Shaul Y. The earliest steps in hepatitis B virus infection. Biochim Biophys Acta. 2003 Jul 11;1614(1):89-96.[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12873769&query_hl=3&itool=pubmed_docsum] [[Category:Viruses]] [[Category:Animal virology]] [[ja:アヒルB型肝炎ウイルス]]