E-selectin 5533371 224271435 2008-07-08T02:34:06Z ProteinBoxBot 3991663 Replaced protein Box Template with PBB Template for easy viewing. {{PBB|geneid=6401}} '''E-selectin''', also known as '''CD62E''', is a [[cell adhesion molecule]] expressed only on [[endothelial]] cells activated by [[cytokine]]s. Like other [[selectin]]s, it plays an important part in [[inflammation]]. == Ligands == E-selectin recognises and binds to sialylated carbohydrates present on the surface proteins of certain [[leukocyte]]s. These carbohydrates include members of the [[Sialyl lewis x|Lewis X]] and [[Sialyl lewis a|Lewis A]] families found on [[monocyte]]s, [[granulocyte]]s, and [[T-lymphocyte]]s<ref name="robspath">{{cite book | title=Robbins Pathologic Basis of Disease| last=Cotran| coauthors=Kumar, Collins| publisher=W.B Saunders Company| location=Philadelphia| id=0-7216-7335-X}}</ref>. == Function == During inflammation, E-selectin plays an important part in [[leukocyte adhesion cascade|recruiting leukocytes]] to the site of injury. The local release of cytokines [[IL-1]] and [[Tumour necrosis factor|TNF]] by damaged cells induces the over-expression of E-selectin on endothelial cells of nearby blood vessels<ref name="robspath"> </ref>. Leukocytes in the blood expressing the correct ligand will bind with low affinity to E-selectin, causing the leukocytes to "roll" along the internal surface of the blood vessel as temporary interactions are made and broken. As the inflammatory response progresses, [[chemokine]]s released by injured tissue enter the blood vessels and activate the rolling leukocytes, which are now able to tightly bind to the endothelial surface and begin making their way into the tissue<ref name="robspath"> </ref>. [[P-selectin]] has a similar function, but is expressed on the endothelial cell surface within minutes as it is stored within the cell rather than produced on demand<ref name="robspath"> </ref>. == External links == * {{MeshName|E-Selectin}} == References == {{reflist}} ==Further reading== {{refbegin | 2}} {{PBB_Further_reading | citations = *{{cite journal | author=Ryan US, Worthington RE |title=Cell-cell contact mechanisms. |journal=Curr. Opin. Immunol. |volume=4 |issue= 1 |pages= 33–7 |year= 1992 |pmid= 1375831 |doi= }} }} {{refend}} {{Cell adhesion molecules}} {{Clusters of differentiation}} [[Category:Cell adhesion proteins]] [[Category:Clusters of differentiation]] [[Category:Glycoproteins]] [[Category:Transmembrane receptors]] <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --> {{PBB_Controls | update_page = yes | require_manual_inspection = no | update_protein_box = yes | update_summary = no | update_citations = yes }}