Endothelin receptor
5827346
219489030
2008-06-15T13:51:39Z
Alaibot
1324179
Robot: sorting stub (based on existing categorisation)
{{protein
|Name=[[endothelin receptor type A]]
|caption=
|image=
|width=
|HGNCid=3179
|Symbol=EDNRA
|AltSymbols=
|EntrezGene=1909
|OMIM=131243
|RefSeq=NM_001957
|UniProt=P25101
|PDB=
|ECnumber=
|Chromosome=4
|Arm=q
|Band=31.2
|LocusSupplementaryData=
}}
{{protein
|Name=[[endothelin receptor type B]]
|caption=
|image=
|width=
|HGNCid=3180
|Symbol=EDNRB
|AltSymbols=HSCR2, HSCR
|EntrezGene=1910
|OMIM=131244
|RefSeq=NM_000115
|UniProt=P24530
|PDB=
|ECnumber=
|Chromosome=13
|Arm=q
|Band=22
|LocusSupplementaryData=
}}
There are at least three known '''[[endothelin]] receptors''', ET<sub>A</sub>, ET<sub>B1</sub> and ET<sub>B2</sub>, all of which are [[G protein-coupled receptor]]s whose activation result in elevation of intracellular-free [[calcium]].<ref name="pmid12037137">{{cite journal | author = Davenport AP | title = International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature | journal = Pharmacol. Rev. | volume = 54 | issue = 2 | pages = 219–26 | year = 2002 | pmid = 12037137 | doi = 10.1124/pr.54.2.219 | issn = }}</ref>
==Clinical significance==
It is associated with [[ABCD syndrome]]<ref name="pmid11891690">{{cite journal | author = Verheij JB, Kunze J, Osinga J, van Essen AJ, Hofstra RM | title = ABCD syndrome is caused by a homozygous mutation in the EDNRB gene | journal = Am. J. Med. Genet. | volume = 108 | issue = 3 | pages = 223–5 | year = 2002 | pmid = 11891690 | doi = 10.1002/ajmg.10172 | issn = }}</ref> and some forms of [[Waardenburg syndrome]].<ref name="pmid9279758">{{cite journal | author = Read AP, Newton VE | title = Waardenburg syndrome | journal = J. Med. Genet. | volume = 34 | issue = 8 | pages = 656–65 | year = 1997 | pmid = 9279758 | doi = | issn = }}</ref>
==See also==
* [[Endothelin receptor antagonist]]
==References==
{{Reflist}}
==External links==
*[http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1283 IUPHAR GPCR Database - Endothelin Receptors]
*{{MeshName|Endothelin+receptor}}
{{transmembranereceptor-stub}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]