Eosinophilia
238806
218602729
2008-06-11T11:09:49Z
Miguel Andrade
569674
/* Causes */ fixed one link
{{DiseaseDisorder infobox |
Name = Eosinophilia |
ICD10 = {{ICD10|D|72|1|d|70}} |
ICD9 = {{ICD9|288.3}} |
ICDO = |
Image = |
Caption = |
OMIM = |
MedlinePlus = |
eMedicineSubj = med |
eMedicineTopic = 685 |
DiseasesDB = 4328 |
MeshID = D004802 |
}}
'''Eosinophilia''' is the state of having a high concentration of '''eosinophils''' ([[eosinophil granulocyte]]s) in the [[blood]]. The normal concentration is between 0 and 0.5 x 10<sup>9</sup> eosinophils per [[litre]] of blood. Eosinophilia can be ''reactive'' (in response to other stimuli such as allergy or infection) or ''non reactive''.
The release of [[interleukin 5]] by [[T cell]]s, [[mast cell]]s and [[macrophage]]s stimulates the production of eosinophils.
==Causes==
Diseases that feature eosinophilia:
* [[Hypereosinophilic syndrome]]
* [[Parasite|Parasitic infection]]s (intestinal [[helminth]]iasis)
* [[allergy|Allergic disorders]]
* Some [[drug reaction]]s
* [[Cholesterol emboli]]zation
* [[Churg-Strauss syndrome]]
* Some forms of [[chronic myeloid leukaemia]]
* [[Hodgkin's disease]]
* [[Gleich's syndrome]]
* [[Addison's disease]]
* [[Clonorchis sinensis]], a type of flatworm
==Management==
If eosinophilia persists for six months, and all major recognized secondary causes have been excluded (parasitic/helminthic infections, HIV, drug hypersensitivity, cancer, lymphomas, and primary allergic disorders), the diagnosis of idiopathic eosinophilia is made. It is modified to [[hypereosinophilic syndrome]] if there is evidence of organ involvement.<ref name="pmid16750989">{{cite journal |author=Klion AD, Bochner BS, Gleich GJ, ''et al'' |title=Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report |journal=J. Allergy Clin. Immunol. |volume=117 |issue=6 |pages=1292-302 |year=2006 |pmid=16750989 |doi=10.1016/j.jaci.2006.02.042| url=http://www.jacionline.org/article/PIIS0091674906005203/fulltext}}</ref>
==See also==
* [[Eosinophilia-myalgia syndrome]]
{{Hematology}}
[[Category:Hematology]]
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