Estrogen receptor alpha
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2008-07-15T16:38:06Z
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'''Estrogen receptor alpha''' ('''ER-alpha'''), also known as '''NR3A1''' (nuclear receptor subfamily 3, group A, member 1), is a [[nuclear receptor]] which is activated by the sex hormone [[estrogen]]. ER-alpha is encoded by the human gene {{gene|ESR1}} (EStrogen Receptor 1).<ref name="entrez">{{cite web | title = Entrez Gene: ESR1 estrogen receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2099| accessdate = }}</ref>
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| summary_text = The estrogen receptor (ESR) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ESR1 mRNA transcripts, which differ primarily in their 5-prime untranslated regions. The translated receptors show less variability.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: ESR1 estrogen receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2099| accessdate = }}</ref>
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==References==
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==Further reading==
{{refbegin | 2}}
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| citations =
*{{cite journal | author=McDonnell DP, Norris JD |title=Connections and regulation of the human estrogen receptor. |journal=Science |volume=296 |issue= 5573 |pages= 1642–4 |year= 2002 |pmid= 12040178 |doi= 10.1126/science.1071884 }}
*{{cite journal | author=Simoncini T, Fornari L, Mannella P, ''et al.'' |title=Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system. Interaction of estrogen receptor alpha with phosphatidylinositol 3-OH kinase. |journal=Steroids |volume=67 |issue= 12 |pages= 935–9 |year= 2003 |pmid= 12398989 |doi= }}
*{{cite journal | author=Lannigan DA |title=Estrogen receptor phosphorylation. |journal=Steroids |volume=68 |issue= 1 |pages= 1–9 |year= 2003 |pmid= 12475718 |doi= }}
*{{cite journal | author=Herrington DM |title=Role of estrogen receptor-alpha in pharmacogenetics of estrogen action. |journal=Curr. Opin. Lipidol. |volume=14 |issue= 2 |pages= 145–50 |year= 2003 |pmid= 12642782 |doi= 10.1097/01.mol.0000064045.68936.23 }}
*{{cite journal | author=Tanaka Y, Sasaki M, Kaneuchi M, ''et al.'' |title=Estrogen receptor alpha polymorphisms and renal cell carcinoma--a possible risk. |journal=Mol. Cell. Endocrinol. |volume=202 |issue= 1-2 |pages= 109–16 |year= 2004 |pmid= 12770739 |doi= }}
*{{cite journal | author=Ali S, Coombes RC |title=Estrogen receptor alpha in human breast cancer: occurrence and significance. |journal=Journal of mammary gland biology and neoplasia |volume=5 |issue= 3 |pages= 271–81 |year= 2004 |pmid= 14973389 |doi= }}
*{{cite journal | author=Olsson H |title=Estrogen receptor content in malignant breast tumors in men--a review. |journal=Journal of mammary gland biology and neoplasia |volume=5 |issue= 3 |pages= 283–7 |year= 2004 |pmid= 14973390 |doi= }}
*{{cite journal | author=Surmacz E, Bartucci M |title=Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer. |journal=J. Exp. Clin. Cancer Res. |volume=23 |issue= 3 |pages= 385–94 |year= 2005 |pmid= 15595626 |doi= }}
*{{cite journal | author=Evinger AJ, Levin ER |title=Requirements for estrogen receptor alpha membrane localization and function. |journal=Steroids |volume=70 |issue= 5-7 |pages= 361–3 |year= 2005 |pmid= 15862818 |doi= 10.1016/j.steroids.2005.02.015 }}
*{{cite journal | author=Wang CL, Tang XY, Chen WQ, ''et al.'' |title=Association of estrogen receptor alpha gene polymorphisms with bone mineral density in Chinese women: a meta-analysis. |journal=Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA |volume=18 |issue= 3 |pages= 295–305 |year= 2007 |pmid= 17089081 |doi= 10.1007/s00198-006-0239-2 }}
*{{cite journal | author=Keaveney M, Klug J, Gannon F |title=Sequence analysis of the 5' flanking region of the human estrogen receptor gene. |journal=DNA Seq. |volume=2 |issue= 6 |pages= 347–58 |year= 1992 |pmid= 1476547 |doi= }}
*{{cite journal | author=Piva R, Gambari R, Zorzato F, ''et al.'' |title=Analysis of upstream sequences of the human estrogen receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=183 |issue= 3 |pages= 996–1002 |year= 1992 |pmid= 1567414 |doi= }}
*{{cite journal | author=Reese JC, Katzenellenbogen BS |title=Characterization of a temperature-sensitive mutation in the hormone binding domain of the human estrogen receptor. Studies in cell extracts and intact cells and their implications for hormone-dependent transcriptional activation. |journal=J. Biol. Chem. |volume=267 |issue= 14 |pages= 9868–73 |year= 1992 |pmid= 1577818 |doi= }}
*{{cite journal | author=Dotzlaw H, Alkhalaf M, Murphy LC |title=Characterization of estrogen receptor variant mRNAs from human breast cancers. |journal=Mol. Endocrinol. |volume=6 |issue= 5 |pages= 773–85 |year= 1992 |pmid= 1603086 |doi= }}
*{{cite journal | author=Keaveney M, Klug J, Dawson MT, ''et al.'' |title=Evidence for a previously unidentified upstream exon in the human oestrogen receptor gene. |journal=J. Mol. Endocrinol. |volume=6 |issue= 1 |pages= 111–5 |year= 1991 |pmid= 2015052 |doi= }}
*{{cite journal | author=Reese JC, Katzenellenbogen BS |title=Mutagenesis of cysteines in the hormone binding domain of the human estrogen receptor. Alterations in binding and transcriptional activation by covalently and reversibly attaching ligands. |journal=J. Biol. Chem. |volume=266 |issue= 17 |pages= 10880–7 |year= 1991 |pmid= 2040605 |doi= }}
*{{cite journal | author=Schwabe JW, Neuhaus D, Rhodes D |title=Solution structure of the DNA-binding domain of the oestrogen receptor. |journal=Nature |volume=348 |issue= 6300 |pages= 458–61 |year= 1991 |pmid= 2247153 |doi= 10.1038/348458a0 }}
*{{cite journal | author=Tora L, Mullick A, Metzger D, ''et al.'' |title=The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties. |journal=EMBO J. |volume=8 |issue= 7 |pages= 1981–6 |year= 1989 |pmid= 2792078 |doi= }}
*{{cite journal | author=Ponglikitmongkol M, Green S, Chambon P |title=Genomic organization of the human oestrogen receptor gene. |journal=EMBO J. |volume=7 |issue= 11 |pages= 3385–8 |year= 1989 |pmid= 3145193 |doi= }}
*{{cite journal | author=Greene GL, Gilna P, Waterfield M, ''et al.'' |title=Sequence and expression of human estrogen receptor complementary DNA. |journal=Science |volume=231 |issue= 4742 |pages= 1150–4 |year= 1986 |pmid= 3753802 |doi= }}
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{{Transcription factors|g2}}
[[Category:Intracellular receptors]]
[[Category:Transcription factors]]
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