Factor XIII deficiency 4304755 224392231 2008-07-08T17:28:38Z Fnielsen 325 /* References */ Format {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = 31412 | ICD10 = {{ICD10|D|68|2|d|65}} | ICD9 = {{ICD9|286.3}} | ICDO = | OMIM = 134570 | OMIM_mult = {{OMIM2|134580}} | MedlinePlus = | eMedicineSubj = ped | eMedicineTopic = 3040 | MeshID = D005177 | }} '''Factor XIII deficiency''' may occur very rarely, and can cause a severe bleeding tendency. Incidence is 1 in a million to 1 in 5 million people. Most are due to mutations in the A subunit. Administration of [[recombinant]] A subunit improves clot stability and may become a therapeutic option for patients with this condition<ref>{{cite journal | author = Lovejoy A, Reynolds T, Visich J, Butine M, Young G, Belvedere M, Blain R, Pederson S, Ishak L, Nugent D | title = Safety and pharmacokinetics of recombinant factor XIII-A2 administration in patients with congenital factor XIII deficiency. | journal = Blood | volume = 108 | issue = 1 | pages = 57–62 | year = 2006 | pmid = 16556896 | doi = 10.1182/blood-2005-02-0788}}</ref>. ==See also== * [[Factor XIII]] ==References== {{Reflist}} {{disease-stub}} {{Hematology}}