Factor XIII deficiency
4304755
224392231
2008-07-08T17:28:38Z
Fnielsen
325
/* References */ Format
{{Infobox_Disease |
Name = {{PAGENAME}} |
Image = |
Caption = |
DiseasesDB = 31412 |
ICD10 = {{ICD10|D|68|2|d|65}} |
ICD9 = {{ICD9|286.3}} |
ICDO = |
OMIM = 134570 |
OMIM_mult = {{OMIM2|134580}} |
MedlinePlus = |
eMedicineSubj = ped |
eMedicineTopic = 3040 |
MeshID = D005177 |
}}
'''Factor XIII deficiency''' may occur very rarely, and can cause a severe bleeding tendency. Incidence is 1 in a million to 1 in 5 million people. Most are due to mutations in the A subunit. Administration of [[recombinant]] A subunit improves clot stability and may become a therapeutic option for patients with this condition<ref>{{cite journal | author = Lovejoy A, Reynolds T, Visich J, Butine M, Young G, Belvedere M, Blain R, Pederson S, Ishak L, Nugent D | title = Safety and pharmacokinetics of recombinant factor XIII-A2 administration in patients with congenital factor XIII deficiency. | journal = Blood | volume = 108 | issue = 1 | pages = 57–62 | year = 2006 | pmid = 16556896 | doi = 10.1182/blood-2005-02-0788}}</ref>.
==See also==
* [[Factor XIII]]
==References==
{{Reflist}}
{{disease-stub}}
{{Hematology}}