Fludrocortisone 692601 212564239 2008-05-15T09:06:00Z Tim Goodwyn 332367 Flourine -> Fluorine. This seems to be becoming a hobby. :P {{drugbox | IUPAC_name = 9-fluoro-11,17-dihydroxy-17- (2-hydroxyacetyl)- 10,13-dimethyl- 1,2,6,7,8,9,10,11,12, 13,14,15,16,17- tetradecahydrocyclopenta[a]phenanthren-3-one | image = fludrocortisone structure.png | CAS_number = 127-31-1 | ATC_prefix = H02 | ATC_suffix = AA02 | ATC_supplemental = | PubChem = 31378 | DrugBank = APRD00756 | C=21 | H=29 | F=1 | O=5 | molecular_weight = 380.45 g/mol | bioavailability = | protein_bound = High | metabolism = Hepatic | elimination_half-life = 3.5 hours | pregnancy_category = C | legal_status = | routes_of_administration = oral }} '''Fludrocortisone''' is a synthetic [[corticosteroid]] with moderate [[glucocorticoid]] potency and much greater [[mineralocorticoid]] potency. It is used primarily to replace the missing hormone [[aldosterone]] in various forms of [[adrenal insufficiency]] such as [[Addison's disease]] and the classic salt wasting (21-hydroxylase deficiency) form of [[congenital adrenal hyperplasia]]. It is the first line of treatment for [[orthostatic intolerance]] as well. The brand name in the U.S. is Florinef. It is available in 0.1 mg tablets. Typical daily doses for mineralocorticoid replacement are between 0.05 mg - 0.2 mg. Renin plasma, sodium, and potassium is checked through blood tests in order to verify that the correct dosage is reached. Chemically, its structure is identical to cortisone except for the substitution of fluorine in place of one hydrogen. Fluorine is a good [[bioisostere]] for hydrogen because it is similar in size. The major difference is in its [[electronegativity]]. [[Category:Mineralocorticoids]] [[Category:Organofluorides]] {{med-stub}} {{pharma-stub}} {{Corticosteroids}} {{Corticosteroids for systemic use}} [[pl:Fludrokortyzon]]