Focal nodular hyperplasia 3962406 223846046 2008-07-06T03:16:18Z Arcadian 104523 nav {{Infobox_Disease | Name = {{PAGENAME}} | Image = | Caption = | DiseasesDB = 33467 | ICD10 = | ICD9 = | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = radio | eMedicineTopic = 286 | MeshID = D020518 | }} '''Focal nodular hyperplasia''' (FNH) is a benign [[tumour]] of the [[liver]] ([[hepatic tumour]]), which is the second most prevalent tumour of the liver (the first is [[hepatic hemangioma]]). It is usually asymptomatic, rarely grows or bleeds, and has no malignant potential. This tumour is often resected because it is difficult to distinguish from [[adenoma#Liver|hepatic adenoma]]. ==Presentation== Focal nodular hyperplasia's most recognizable gross feature is a central stellate scar seen in 60-70% of cases. Microscopically, a lobular proliferation of bland-appearing hepatocytes with a bile ductular proliferation and malformed vessels within the fibrous scar is the most common pattern. Other patterns include telangiectatic, hyperplastic-adenomatous, and lesions with focal large-cell dysplasia.<ref name=Nguyen>Nguyen et al. Focal Nodular Hyperplasia of the Liver: A Comprehensive Pathologic Study of 305 Lesions and Recognition of New Histologic Forms. Am J Surg Path 1999:23(12); 1441-4.</ref> Rarely, these lesions may be multiple or can occur as part of a syndrome with hemangiomas, epithelioid hemangioendothelioma, hepatic adenomas, fibrolamellar hepatocellular carcinoma, vascular malformations of the brain, meningiomas, and/or astrocytomas.<ref name=Nguyen/> ==Notes== {{Reflist}} ==References== {{refimprove|date=August 2007}} [[Category:Hepatology]] {{disease-stub}} {{Digestive system neoplasia}} [[pl:Ogniskowy rozrost guzkowy wÄ…troby]]