Frontal lobe
469220
226176515
2008-07-17T04:33:34Z
60.241.82.45
{{Expand|date=September 2007}}
{{Infobox Brain|
Name = Frontal lobe |
Latin = lobus frontalis |
GraySubject = 189 |
GrayPage = 821 |
Map = Cerebrum map|
MapPos = |
MapCaption = Principal fissures and lobes of the [[cerebrum]] viewed laterally. (Frontal lobe is blue.) |
Image = |
Caption = |
Image2 = Gray729.png |
Caption2 = Orbital surface of left frontal lobe. |
IsPartOf = [[Cerebrum]]|
Components = |
Artery = [[Anterior cerebral artery|Anterior cerebral]] <br/> [[Middle cerebral artery|Middle cerebral]]|
Vein = |
Acronym = FL |
BrainInfoType = hier |
BrainInfoNumber = 37 |
MeshName = Frontal+Lobe |
MeshNumber = A08.186.211.730.885.213.270 |
}}
The '''frontal lobe''' is an area in the [[brain]] of [[mammal]]s. Located at the front of each [[cerebral hemisphere]], frontal lobes are positioned in front of (anterior to) the [[parietal lobe]]s. The [[temporal lobe]]s are located beneath and behind the frontal lobes.
In the human brain, the precentral [[gyrus]] and the related cortical tissue that folds into the [[central sulcus]] comprise the [[primary motor cortex]], which controls voluntary movements of specific body parts associated with areas of the gyrus.
Cognitive maturity associated with adulthood is marked by related maturation of cerebral fibers in the frontal lobes between late teenager years and early adult years. The frontal lobe reaches full maturity around age 25. Research by Arthur Toga, UCLA, found increased [[myelin]] in the frontal lobe white matter of young adults compared to that of teens, whereas grey matter in parietal and temporal lobes was more fully matured by teen years. Typical onset of schizophrenia in early adult years correlates with poorly myelinated and thus inefficient connections between cells in the fore-brain.
A report from the National Institute of Mental Health says a gene variant that reduces dopamine activity in the [[prefrontal cortex]] is related to poorer performance and inefficient functioning of that brain region during working memory tasks, and to slightly increased risk for [[schizophrenia]].
Dopamine-sensitive neurons in the [[cerebral cortex]] are found primarily in the frontal lobes. The [[dopamine]] system is associated with pleasure, long-term memory, planning and drive. Dopamine tends to limit and select sensory information arriving from the [[thalamus]] to the fore-brain. Poor regulation of dopamine pathways has been associated with schizophrenia.
The so-called [[executive function]]s of the frontal lobes involve the ability to recognize future consequences resulting from current actions, to choose between good and bad actions (or better and best), override and suppress unacceptable social responses, and determine similarities and differences between things or events.
The frontal lobes also play an important part in retaining longer term memories which are not task-based. These are often memories with associated emotions, derived from input from the brain's limbic system, and modified by the higher frontal lobe centers to generally fit socially acceptable norms (see [[executive function]]s above). The frontal lobes have rich neuronal input from both the alert centers in the brain-stem, and from the limbic regions.
Psychological tests that measure frontal lobe function include Finger tapping, [[Wisconsin Card Sorting Task]], and measures of verbal and figural fluency.<ref>Kimberg, D.Y., Farah, M.J. A unified account of cognitive impariments following frontal lobe damage: the role of working memory in complex, organized behavior. J. Exp. Psychol. Gen. 1993 122(4):411-28</ref>
== Psychosurgery ==
In the early 20th century, a medical treatment for [[mental illness]], first developed by [[Portugal|Portuguese]] [[neurologist]] [[Egas Moniz]], involved damaging the pathways connecting the frontal lobe to the [[limbic system]]. Frontal [[lobotomy]] (sometimes called frontal leucotomy) successfully reduced distress but at the cost of often blunting the subject's emotions, volition and [[personality psychology|personality]]. The indiscriminate use of this [[psychosurgery|psychosurgical]] procedure, combined with the severe side effects and dangerous nature of the operation gained it a bad reputation and the frontal lobotomy has largely died out as a psychiatric treatment.
More precise psychosurgical procedures are still occasionally used, although are now very rare occurrences. They may include procedures such as the anterior capsulotomy (bilateral thermal lesions of the anterior limbs of the [[internal capsule]]) or the [[bilateral cingulotomy]] (bilateral they are one lesions of the anterior [[cingulate gyrus|cingulate gyri]]) and might be used to treat otherwise untreatable [[obsessive-compulsive disorder|obsessional disorders]] or [[clinical depression]].
== Theories of function ==
{{Cleanup-section|date=May 2008}}
Theories of frontal lobe function can be differentiated into three categories: single-process theories, construct-led theories, and multi-process theories (Burgess & Simons, 2005; Burgess, 2003). Actually Burgess (2003) and Burgess & Simons (2005) name a fourth category: single symptom theories. However, single symptom theories are different from the other three ones since they focus on the investigation of a specific dysexecutive symptom (e.g., confabulation) and relate that symptom to the underlying structures (processes, construct) in a top-bottom approach (cf. Burgess & Simons, 2005). Stuss (1999) suggests a differentiation into two categories according to homogeneity and heterogeneity of function. A single-process theory posits “that damage to a single process or system is responsible for a number of different dysexecutive symptoms” (Burgess, 2003, p. 309). In a construct-led theory it is assumed “that most if not all frontal functions can be explained by one construct (homogeneity of function) such as working memory or inhibition” (Stuss, 1999, p. 348; cf. Burgess & Simons, 2005). Multi-process theories “propose that the frontal lobe executive system consists of a number of components that typically work together in everyday actions [(heterogeneity of function)]“ (Burgess, 2003, p. 310).
Further theoretical approaches to frontal lobe function include: Grafman's managerial knowledge units (MKU) / structured event complex (SEC) approach (cf. Wood & Grafman, 2003), Miller & Cohen's integrative theory of prefrontal functioning (e.g. Miller & Cohen, 2001), Rolls's stimulus-reward approach and Stuss's anterior attentional functions (Burgess & Simons, 2005; Burgess, 2003; Burke, 2007).
It must be highlighted that the theories described above differ in their focus on certain processes/systems or construct-lets. Stuss (1999) remarks that the question of homogeneity (single construct) or heterogeneity (multiple processes/systems) of function “may represent a problem of semantics and/or incomplete functional analysis rather than an unresolvable dichotomy” (p. 348). However, further research will show if a unified theory of frontal lobe function that fully accounts for the diversity of functions will be available.
== Damage ==
Damage to one's frontal lobes can do a variation of things:
*Mental flexibility and spontaneity is impaired, but one's IQ would not lower.
*Talking may increase or decrease dramatically.
*Senses regarding risk taking and rule abiding are impaired.
*Socialization can diminish or increase.
*Orbital frontal lobe damage can result in peculiar sexual habits (only discovered in animals).
*Dorsolateral frontal lobe damage reduces sexual interest.
==Additional images==
<gallery>
Image:Illu cerebrum lobes.jpg|Lobes
Image:Gray724.png|Base of brain.
Image:Gray1197.png|Drawing to illustrate the relations of the brain to the skull.
</gallery>
==See also==
*[[Frontal lobe injury]]
*[[Lobes of the brain|Brain lobes]]
*[[Broca's area|Broca's Area]]
*[[list of regions in the human brain|Regions in the human brain]]
*[[Phineas Gage]] - Railroad worker who survived a metal rod being driven through his forebrain
==References==
<References />
__NOTOC__
{{Prosencephalon}}
[[Category:Cerebrum]]
[[de:Frontallappen]]
[[es:Lóbulo frontal]]
[[fa:لوب پیشانی]]
[[fr:Lobe frontal]]
[[nl:Frontale kwab]]
[[ja:前頭葉]]
[[no:Frontallapp]]
[[pl:Płat czołowy]]
[[fi:Otsalohko]]
[[sv:Frontallob]]
[[zh:額葉]]