Fructose 1,6-bisphosphate 5712189 210656577 2008-05-06T21:04:20Z Rockfang 5403270 changing stub name per [[Wikipedia:Stub_types_for_deletion/Log/2008/March/19|SfD]] using [[Project:AutoWikiBrowser|AWB]] {{Chembox new |ImageFile=Beta-D-fructose-1,6-bisphosphate wpmp.png |ImageSize=150px |IUPACName= |OtherNames= |Section1= {{Chembox Identifiers | CASNo=488-69-7 | PubChem=172313 | SMILES=C(C1C(C(C(O1)(COP(=O)(O)O)O)O)O)OP(=O)(O)O | MeSHName=fructose-1,6-diphosphate }} |Section2= {{Chembox Properties | Formula=C<sub>6</sub>H<sub>14</sub>O<sub>12</sub>P<sub>2</sub> | MolarMass=340.116 | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= }} |Section3= {{Chembox Hazards | MainHazards= | FlashPt= | Autoignition= }} }} '''Fructose 1,6-phosphate''' is [[fructose]] sugar [[phosphorylated]] on carbons 1 and 6 (ie. is a [[fructosephosphate]]). The β-<small>D</small>-form of this compound is very common in [[cell (biology)|cells]]. The vast majority of [[glucose]] and fructose entering a cell will become converted to fructose 1,6-phosphate at some point. ==Fructose 1,6-phosphate in glycolysis== Fructose 1,6-phosphate lies within the [[glycolysis]] [[metabolic pathway]] and is produced by phosphorylation of [[fructose 6-phosphate]]. It is in turn broken down into two compounds; [[glyceraldehyde 3-phosphate]] and [[dihydroxyacetone phosphate]]. It is an [[allosteric]] activator of [[pyruvate kinase]]. {{ Complex biochemical reaction |reaction_A_major_substrate_1=β-<small>D</small>-[[fructose 6-phosphate]] |reaction_A_major_substrate_1_image=beta-D-fructose-6-phosphate_wpmp.png |reaction_A_major_substrate_1_stoichiometric_constant= |reaction_A_major_substrate_2= |reaction_A_major_substrate_2_image= |reaction_A_major_substrate_2_stoichiometric_constant= |reaction_A_foward_enzyme=[[6-phosphofructo 1-kinase]] |reaction_A_reverse_enzyme=[[Hexose diphosphatase]] |reaction_A_reaction_direction_(foward/reversible/reverse)=reversible |reaction_A_minor_reverse_product(s)=P<sub>i</sub> |reaction_A_minor_reverse_substrate(s)=H<sub>2</sub>O |reaction_A_minor_foward_substrate(s)=[[adenosine triphosphate|ATP]] |reaction_A_minor_foward_product(s)=[[ADP]] |reaction_A_major_product_1=β-<small>D</small>-[[fructose 1,6-phosphate]] |reaction_A_major_product_1_image=beta-D-fructose-1,6-bisphosphate_wpmp.png |reaction_A_major_product_1_stoichiometric_constant= |reaction_A_major_product_2= |reaction_A_major_product_2_image= |reaction_A_major_product_2_stoichiometric_constant= |reaction_B_foward_enzyme=[[Fructose bisphosphate aldolase]] |reaction_B_reverse_enzyme=[[Fructose bisphosphate aldolase]] |reaction_B_reaction_direction_(foward/reversible/reverse)=reversible |reaction_B_minor_foward_substrate(s)= |reaction_B_minor_foward_product(s)= |reaction_B_minor_reverse_product(s)= |reaction_B_minor_reverse_substrate(s)= |reaction_B_major_product_1=<small>D</small>-[[glyceraldehyde 3-phosphate]] |reaction_B_major_product_1_image=D-glyceraldehyde-3-phosphate_wpmp.png |reaction_B_major_product_1_stoichiometric_constant= |reaction_B_major_product_2=[[dihydroxyacetone phosphate]] |reaction_B_major_product_2_image=glycerone-phosphate_wpmp.png |reaction_B_major_product_2_stoichiometric_constant= }} {{KEGG compound|C05345}} {{KEGG enzyme|2.7.1.11}} {{KEGG enzyme|3.1.3.11}} {{KEGG compound|C05378}} {{KEGG enzyme|4.1.2.13}} {{KEGG compound|C00111}} {{KEGG compound|C00118}} ''The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate.'' ==Fructose 1,6-phosphate isomerism== {{main|Fructose}} Fructose 1,6-phosphate has only one biologically active [[isomer]], the β-<small>D</small>-form. There are many other isomers, analogous to those of fructose. ==See also== * [[Fructose 2,6-bisphosphate]] {{Glycolysis}} {{metabolism-stub}} [[Category:Organophosphates]] [[fr:Fructose 1,6-diphosphate]] [[ja:フルクトース-1,6-ビスリン酸]] [[pt:Frutose-1,6-bisfosfato]] [[zh:果糖-1,6-雙磷酸]]