Fructose 1,6-bisphosphate
5712189
210656577
2008-05-06T21:04:20Z
Rockfang
5403270
changing stub name per [[Wikipedia:Stub_types_for_deletion/Log/2008/March/19|SfD]] using [[Project:AutoWikiBrowser|AWB]]
{{Chembox new
|ImageFile=Beta-D-fructose-1,6-bisphosphate wpmp.png
|ImageSize=150px
|IUPACName=
|OtherNames=
|Section1= {{Chembox Identifiers
| CASNo=488-69-7
| PubChem=172313
| SMILES=C(C1C(C(C(O1)(COP(=O)(O)O)O)O)O)OP(=O)(O)O
| MeSHName=fructose-1,6-diphosphate
}}
|Section2= {{Chembox Properties
| Formula=C<sub>6</sub>H<sub>14</sub>O<sub>12</sub>P<sub>2</sub>
| MolarMass=340.116
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
}}
|Section3= {{Chembox Hazards
| MainHazards=
| FlashPt=
| Autoignition=
}}
}}
'''Fructose 1,6-phosphate''' is [[fructose]] sugar [[phosphorylated]] on carbons 1 and 6 (ie. is a [[fructosephosphate]]). The β-<small>D</small>-form of this compound is very common in [[cell (biology)|cells]]. The vast majority of [[glucose]] and fructose entering a cell will become converted to fructose 1,6-phosphate at some point.
==Fructose 1,6-phosphate in glycolysis==
Fructose 1,6-phosphate lies within the [[glycolysis]] [[metabolic pathway]] and is produced by phosphorylation of [[fructose 6-phosphate]]. It is in turn broken down into two compounds; [[glyceraldehyde 3-phosphate]] and [[dihydroxyacetone phosphate]]. It is an [[allosteric]] activator of [[pyruvate kinase]].
{{ Complex biochemical reaction
|reaction_A_major_substrate_1=β-<small>D</small>-[[fructose 6-phosphate]]
|reaction_A_major_substrate_1_image=beta-D-fructose-6-phosphate_wpmp.png
|reaction_A_major_substrate_1_stoichiometric_constant=
|reaction_A_major_substrate_2=
|reaction_A_major_substrate_2_image=
|reaction_A_major_substrate_2_stoichiometric_constant=
|reaction_A_foward_enzyme=[[6-phosphofructo 1-kinase]]
|reaction_A_reverse_enzyme=[[Hexose diphosphatase]]
|reaction_A_reaction_direction_(foward/reversible/reverse)=reversible
|reaction_A_minor_reverse_product(s)=P<sub>i</sub>
|reaction_A_minor_reverse_substrate(s)=H<sub>2</sub>O
|reaction_A_minor_foward_substrate(s)=[[adenosine triphosphate|ATP]]
|reaction_A_minor_foward_product(s)=[[ADP]]
|reaction_A_major_product_1=β-<small>D</small>-[[fructose 1,6-phosphate]]
|reaction_A_major_product_1_image=beta-D-fructose-1,6-bisphosphate_wpmp.png
|reaction_A_major_product_1_stoichiometric_constant=
|reaction_A_major_product_2=
|reaction_A_major_product_2_image=
|reaction_A_major_product_2_stoichiometric_constant=
|reaction_B_foward_enzyme=[[Fructose bisphosphate aldolase]]
|reaction_B_reverse_enzyme=[[Fructose bisphosphate aldolase]]
|reaction_B_reaction_direction_(foward/reversible/reverse)=reversible
|reaction_B_minor_foward_substrate(s)=
|reaction_B_minor_foward_product(s)=
|reaction_B_minor_reverse_product(s)=
|reaction_B_minor_reverse_substrate(s)=
|reaction_B_major_product_1=<small>D</small>-[[glyceraldehyde 3-phosphate]]
|reaction_B_major_product_1_image=D-glyceraldehyde-3-phosphate_wpmp.png
|reaction_B_major_product_1_stoichiometric_constant=
|reaction_B_major_product_2=[[dihydroxyacetone phosphate]]
|reaction_B_major_product_2_image=glycerone-phosphate_wpmp.png
|reaction_B_major_product_2_stoichiometric_constant=
}}
{{KEGG compound|C05345}} {{KEGG enzyme|2.7.1.11}} {{KEGG enzyme|3.1.3.11}} {{KEGG compound|C05378}} {{KEGG enzyme|4.1.2.13}} {{KEGG compound|C00111}} {{KEGG compound|C00118}}
''The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate.''
==Fructose 1,6-phosphate isomerism==
{{main|Fructose}}
Fructose 1,6-phosphate has only one biologically active [[isomer]], the β-<small>D</small>-form. There are many other isomers, analogous to those of fructose.
==See also==
* [[Fructose 2,6-bisphosphate]]
{{Glycolysis}}
{{metabolism-stub}}
[[Category:Organophosphates]]
[[fr:Fructose 1,6-diphosphate]]
[[ja:フルクトース-1,6-ビスリン酸]]
[[pt:Frutose-1,6-bisfosfato]]
[[zh:果糖-1,6-雙磷酸]]