Fumagillin
1865729
216628553
2008-06-02T14:27:14Z
ChemNerd
2246483
Quick-adding category "Epoxides" (using [[WP:HOTCAT|HotCat]])
{{drugbox
| image = Fumagillin.svg
| IUPAC_name = (2''E'',4''E'',6''E'',8''E'')-10-{[(3''S'',4''S'',5''S'',6''R'')-<br>5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)<br>oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy}-<br>10-oxo-deca-2,4,6,8-tetraenoic acid
| CAS_number = 23110-15-8
| ATC_prefix = P01
| ATC_suffix = AX10
| ATC_supplemental =
| PubChem = 6436022
| DrugBank = EXPT01509
| C=26 | H=36 | O=7
| molecular_weight = 460.566 g/mol
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| pregnancy_category =
| legal_status =
| routes_of_administration =
}}
'''Fumagillin''' is an [[antibiotic]] originally used against [[fungi|fungal]] ''[[Nosema apis]]'' infections in [[honeybee]]s. Some studies found it to be effective against some [[myxozoa]]n [[parasite]]s, including ''[[Myxobolus cerebralis]],'' an important parasite of [[fish]]; however, in the more rigorous tests required for [[U.S.]] [[Food and Drug Administration]] approval, it was ineffective. Fumagillin can block blood vessel formation by binding to an [[enzyme]] called methionine aminopeptidase 2.<ref>
{{cite journal
|url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14533670&dopt=Abstract
|author=Gilbert, M. A. & Granath, W.O. Jr.
|year=2003
|title=Whirling disease and salmonid fish: life cycle, biology, and disease
|journal=[[Journal of Parasitology]]
|volume=89
|issue=4
|pages=pp. 658–667
|doi=10.1645/GE-82R
}}</ref>
There are reports that Fumagillin might play a role in controlling [[Nosema ceranae]], which has recently been hypothesized as a possible cause of [[Colony Collapse Disorder]].<ref>
{{cite news
|url=http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2007/04/26/MNGK7PFOMS1.DTL
|title=UCSF scientist tracks down suspect in honeybee deaths
|author=Sabin Russell
|date=2007-04-26
|publisher=[[San Francisco Chronicle]]
|language=English
}}</ref><ref>
{{cite news
|url=http://sev.prnewswire.com/agriculture/20070425/NEW13725042007-1.html
|title=Scientists Identify Pathogens That May Be Causing Global Honeybee Deaths
|author=
|date=2007-04-25
|publisher=[[PR Newswire]]
|language=English
}}</ref>
==References==
{{Reflist}}
[[Category:parasitology]]
[[Category:Beekeeping]]
[[Category:Epoxides]]
{{pharma-stub}}
{{Agents against amoebiasis and other protozoal diseases}}
[[es:Fumagilina]]