Fumagillin 1865729 216628553 2008-06-02T14:27:14Z ChemNerd 2246483 Quick-adding category "Epoxides" (using [[WP:HOTCAT|HotCat]]) {{drugbox | image = Fumagillin.svg | IUPAC_name = (2''E'',4''E'',6''E'',8''E'')-10-{[(3''S'',4''S'',5''S'',6''R'')-<br>5-methoxy-4-[2-methyl-3-(3-methylbut-2-enyl)<br>oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy}-<br>10-oxo-deca-2,4,6,8-tetraenoic acid | CAS_number = 23110-15-8 | ATC_prefix = P01 | ATC_suffix = AX10 | ATC_supplemental = | PubChem = 6436022 | DrugBank = EXPT01509 | C=26 | H=36 | O=7 | molecular_weight = 460.566 g/mol | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | pregnancy_category = | legal_status = | routes_of_administration = }} '''Fumagillin''' is an [[antibiotic]] originally used against [[fungi|fungal]] ''[[Nosema apis]]'' infections in [[honeybee]]s. Some studies found it to be effective against some [[myxozoa]]n [[parasite]]s, including ''[[Myxobolus cerebralis]],'' an important parasite of [[fish]]; however, in the more rigorous tests required for [[U.S.]] [[Food and Drug Administration]] approval, it was ineffective. Fumagillin can block blood vessel formation by binding to an [[enzyme]] called methionine aminopeptidase 2.<ref> {{cite journal |url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14533670&dopt=Abstract |author=Gilbert, M. A. & Granath, W.O. Jr. |year=2003 |title=Whirling disease and salmonid fish: life cycle, biology, and disease |journal=[[Journal of Parasitology]] |volume=89 |issue=4 |pages=pp. 658–667 |doi=10.1645/GE-82R }}</ref> There are reports that Fumagillin might play a role in controlling [[Nosema ceranae]], which has recently been hypothesized as a possible cause of [[Colony Collapse Disorder]].<ref> {{cite news |url=http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2007/04/26/MNGK7PFOMS1.DTL |title=UCSF scientist tracks down suspect in honeybee deaths |author=Sabin Russell |date=2007-04-26 |publisher=[[San Francisco Chronicle]] |language=English }}</ref><ref> {{cite news |url=http://sev.prnewswire.com/agriculture/20070425/NEW13725042007-1.html |title=Scientists Identify Pathogens That May Be Causing Global Honeybee Deaths |author= |date=2007-04-25 |publisher=[[PR Newswire]] |language=English }}</ref> ==References== {{Reflist}} [[Category:parasitology]] [[Category:Beekeeping]] [[Category:Epoxides]] {{pharma-stub}} {{Agents against amoebiasis and other protozoal diseases}} [[es:Fumagilina]]