Fumarase
4032737
173000375
2007-11-21T23:05:34Z
Alaibot
1324179
Robot: sorting stub (based on existing categorisation)
{{protein
|Name=fumarate hydratase
|caption=
|image=
|width=
|HGNCid=3700
|Symbol=FH
|AltSymbols=
|EntrezGene=2271
|OMIM=136850
|RefSeq=NM_000143
|UniProt=P07954
|PDB=
|ECnumber=4.2.1.2
|Chromosome=1
|Arm=q
|Band=42.1
|LocusSupplementaryData=
}}
'''Fumarase''' (or '''fumarate hydratase''') is an [[enzyme]] involved in the [[Krebs Cycle]] (aka the Tricarboxylic Acid Cycle aka the Citric Acid Cycle) that [[catalyzes]] the [[hydration]] (addition of [[Water (Molecule)|H<sub>2</sub>O]] across a [[double bond]]) of [[Fumarate]] to L-[[malate]] (See the entry on [[optical isomer]]).
Fumarate + H2O <-> L Malate
==Biochemical Pathway==
* Diagram [http://www.genome.jp/kegg/pathway/map/map00020.html TCA Cycle] at [http://www.gehome.jp/kegg KEGG], gives some details on the [[TCA cycle]] in which '''fumerase''' acts. [Fumarase is labeled '4.2.1.2' in the lower left hand corner of this diagram.
* [http://www.biocheminfo.org/klotho/html/fumarate.html structure of Fumarate]
* [http://www.biocheminfo.org/klotho/html/L-malate.html Structure of L Malate]
* See also [[Citric acid cycle|Citric Acid Cycle]] on Wikipedia.
==See also==
*[[Fumarase deficiency]]
==External links==
* [http://www.rcsb.org/pdb/explore.do?structureId=1YFM Crystal structure of Yeast Fumarase] at the Protein Data Bank.
* {{MeshName|Fumarase}}
[[Category:EC 4.2.1]]
{{4.2-enzyme-stub}}
{{Carbon-oxygen lyases}}
{{Citric acid cycle enzymes}}
{{Mitochondrial enzymes}}
[[de:Fumarase]]
[[it:Fumarato idratasi]]
[[hu:Fumaráz]]