Fumarase 4032737 173000375 2007-11-21T23:05:34Z Alaibot 1324179 Robot: sorting stub (based on existing categorisation) {{protein |Name=fumarate hydratase |caption= |image= |width= |HGNCid=3700 |Symbol=FH |AltSymbols= |EntrezGene=2271 |OMIM=136850 |RefSeq=NM_000143 |UniProt=P07954 |PDB= |ECnumber=4.2.1.2 |Chromosome=1 |Arm=q |Band=42.1 |LocusSupplementaryData= }} '''Fumarase''' (or '''fumarate hydratase''') is an [[enzyme]] involved in the [[Krebs Cycle]] (aka the Tricarboxylic Acid Cycle aka the Citric Acid Cycle) that [[catalyzes]] the [[hydration]] (addition of [[Water (Molecule)|H<sub>2</sub>O]] across a [[double bond]]) of [[Fumarate]] to L-[[malate]] (See the entry on [[optical isomer]]). Fumarate + H2O <-> L Malate ==Biochemical Pathway== * Diagram [http://www.genome.jp/kegg/pathway/map/map00020.html TCA Cycle] at [http://www.gehome.jp/kegg KEGG], gives some details on the [[TCA cycle]] in which '''fumerase''' acts. [Fumarase is labeled '4.2.1.2' in the lower left hand corner of this diagram. * [http://www.biocheminfo.org/klotho/html/fumarate.html structure of Fumarate] * [http://www.biocheminfo.org/klotho/html/L-malate.html Structure of L Malate] * See also [[Citric acid cycle|Citric Acid Cycle]] on Wikipedia. ==See also== *[[Fumarase deficiency]] ==External links== * [http://www.rcsb.org/pdb/explore.do?structureId=1YFM Crystal structure of Yeast Fumarase] at the Protein Data Bank. * {{MeshName|Fumarase}} [[Category:EC 4.2.1]] {{4.2-enzyme-stub}} {{Carbon-oxygen lyases}} {{Citric acid cycle enzymes}} {{Mitochondrial enzymes}} [[de:Fumarase]] [[it:Fumarato idratasi]] [[hu:Fumaráz]]