Gliclazide 5360146 217232575 2008-06-05T04:34:40Z Thijs!bot 1392310 robot Adding: [[zh:岱蜜克龍]] {{drugbox | IUPAC_name = 3-(7-azabicyclo[3.3.0]oct-7-yl)-<br />1-(4-methylphenyl)sulfonyl-urea | image = Gliclazide.svg | CAS_number = 21187-98-4 | ATC_prefix = A10 | ATC_suffix = BB09 | PubChem = 3475 | DrugBank = APRD00460 | C = 15 |H = 21 |N = 3 |O = 3 |S = 1 | molecular_weight = 323.412 [[Gram|g]]/[[Mole (unit)|mol]] | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | pregnancy_category = | legal_status = | routes_of_administration = }} '''Gliclazide''' is an oral hypoglycemic ([[anti-diabetic drug]]) and is classified as a [[sulfonylurea]]. It is marketed as '''Diamicron MR''' and Dianorm-In India. '''DIAMICRON MR''' is also distributed as: Diabeton MR, Diamicron 30mg, Diamicron LM 30mg, Diamicron MR 30 mg, Diamicron Uno 30mg, Dianormax MR, Diaprel MR and Uni Diamicron. == Form and Composition: == Each tablet contains 80 mg of gliclazide. Not marketed in the United States. == Indication: == Control of hyperglycemia in gliclazide responsive diabetes mellitus of stable, mild, non-ketosis prone, maturity onset or adult type which cannot be controlled by proper dietary management and exercise, or when insulin therapy is not appropriate. == Dosage: == 40 to 240 mg depending on response, once or twice daily before food, no more than 160 mg at a time. == Properties: == Hypoglycemic sulfonylurea, restoring first peak of insulin secretion, increasing insulin sensitivity. Glycemia-independent hemovascular effects, antioxidant effect. No active circulating metabolites. == Contraindications: == type 1 diabetes, hypersensitivity to sulfonylureas, severe renal or hepatic failure, pregnancy and lactation, miconazole coprescription. == Interactions: == Hyperglycemic action may be caused by danazol, chlorpromazine, glucocorticoids, progestogens, β-2 agonists. Its hypoglycemic action may be potentiated by phenylbutazone, alcohol, fluconazole, β-blockers, possibly ACE inhibitors. == Adverse effects: == Hypoglycemia, gastrointestinal disturbance (reported), skin reactions (rare), hematological disorders (rare), hepatic enzyme rises (exceptional). == Overdosage: == Possible severe hypoglycemia requiring urgent IV glucose and monitoring. ==External links== *[http://www.diamicronmr.com Official site for Diamicron MR] {{Oral_hypoglycemics}} [[Category:Sulfonylureas]] {{pharma-stub}} [[fr:Gliclazide]] [[hu:Gliklazid]] [[zh:岱蜜克龍]]