Gliclazide
5360146
217232575
2008-06-05T04:34:40Z
Thijs!bot
1392310
robot Adding: [[zh:岱蜜克龍]]
{{drugbox
| IUPAC_name = 3-(7-azabicyclo[3.3.0]oct-7-yl)-<br />1-(4-methylphenyl)sulfonyl-urea
| image = Gliclazide.svg
| CAS_number = 21187-98-4
| ATC_prefix = A10
| ATC_suffix = BB09
| PubChem = 3475
| DrugBank = APRD00460
| C = 15 |H = 21 |N = 3 |O = 3 |S = 1
| molecular_weight = 323.412 [[Gram|g]]/[[Mole (unit)|mol]]
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| pregnancy_category =
| legal_status =
| routes_of_administration =
}}
'''Gliclazide''' is an oral hypoglycemic ([[anti-diabetic drug]]) and is classified as a [[sulfonylurea]]. It is marketed as '''Diamicron MR''' and Dianorm-In India.
'''DIAMICRON MR''' is also distributed as:
Diabeton MR, Diamicron 30mg, Diamicron LM 30mg, Diamicron MR 30 mg, Diamicron Uno 30mg, Dianormax MR, Diaprel MR and Uni Diamicron.
== Form and Composition: ==
Each tablet contains 80 mg of gliclazide.
Not marketed in the United States.
== Indication: ==
Control of hyperglycemia in gliclazide responsive diabetes mellitus of stable, mild, non-ketosis prone, maturity onset or adult type which cannot be controlled by proper dietary management and exercise, or when insulin therapy is not appropriate.
== Dosage: ==
40 to 240 mg depending on response, once or twice daily before food, no more than 160 mg at a time.
== Properties: ==
Hypoglycemic sulfonylurea, restoring first peak of insulin secretion, increasing insulin sensitivity.
Glycemia-independent hemovascular effects, antioxidant effect.
No active circulating metabolites.
== Contraindications: ==
type 1 diabetes,
hypersensitivity to sulfonylureas,
severe renal or hepatic failure,
pregnancy and lactation,
miconazole coprescription.
== Interactions: ==
Hyperglycemic action may be caused by danazol, chlorpromazine, glucocorticoids, progestogens, β-2 agonists.
Its hypoglycemic action may be potentiated by phenylbutazone, alcohol, fluconazole, β-blockers, possibly ACE inhibitors.
== Adverse effects: ==
Hypoglycemia, gastrointestinal disturbance (reported), skin reactions (rare), hematological disorders (rare), hepatic enzyme rises (exceptional).
== Overdosage: ==
Possible severe hypoglycemia requiring urgent IV glucose and monitoring.
==External links==
*[http://www.diamicronmr.com Official site for Diamicron MR]
{{Oral_hypoglycemics}}
[[Category:Sulfonylureas]]
{{pharma-stub}}
[[fr:Gliclazide]]
[[hu:Gliklazid]]
[[zh:岱蜜克龍]]