Glucose-6-phosphate isomerase
1936865
210655259
2008-05-06T20:58:21Z
Rockfang
5403270
changing stub name per [[Wikipedia:Stub_types_for_deletion/Log/2008/March/19|SfD]] , typos fixed: Km → km using [[Project:AutoWikiBrowser|AWB]]
{{Protbox
| Name =Glucose phosphate isomerase
|Photo=Glucose-6-phosphate isomerase 1GZV wpmp.png
|Caption={{{!}} align="center" border="0"
{{!}} '''Enzyme'''
{{!}} Glucose-6-phosphate isomerase
{{!}}-
{{!}} '''PDB Code'''
{{!}} {{PDB|1GZV}}
{{!}}-
{{!}} '''Organism'''
{{!}} [[Pig]]
{{!}}-
{{!}} '''Tissue'''
{{!}} [[Muscle]]
{{!}}-
{{!}} '''Complexed molecules'''
{{!}} [[5-phosphoarabinoate]]
{{!}}}
| HGNCid = 4458
| Symbol = GPI
|AltSymbols =
| Chromosome = 19
| Arm = q
| Band = 13.1
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| EntrezGene = 2821
| OMIM = 172400
| RefSeq = NM_000175
| UniProt = P06744
|PDB =
| ECnumber = 5.3.1.9
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'''Glucose-6-phosphate isomerase''', or '''phosphoglucose isomerase''', is an [[enzyme]] ({{EC number|5.3.1.9}}) that catalyzes the conversion of [[glucose-6-phosphate]] into [[fructose-6-phosphate]] in the second step of [[glycolysis]]. An unrelated enzyme, [[D-xylose isomerase]] ({{EC number|5.3.1.5}}) catalyzes the isomerization of [[glucose]] to [[fructose]], and is sometimes called "glucose isomerase".
The human variant of this enzyme is encoded by the [[GPI (gene)|GPI]] [[gene]].
==In glycolysis==
{{Enzymatic Reaction
|foward_enzyme=[[Phosphoglucose isomerase]]
|reverse_enzyme=[[Phosphoglucose isomerase]]
|substrate=α-<small>D</small>-[[Glucose 6-phosphate]]
|product=β-<small>D</small>-[[Fructose 6-phosphate]]
|reaction_direction_(foward/reversible/reverse)=reversible
|minor_foward_substrate(s)=
|minor_foward_product(s)=
|minor_reverse_substrate(s)=
|minor_reverse_product(s)=
|substrate_image=Glucose-6-phosphate_wpmp.png
|product_image=Fructose-6-phosphate_wpmp.png
}}
{{KEGG compound|C00668}} {{KEGG enzyme|5.3.1.9}} {{KEGG compound|C05345}} {{KEGG reaction|R00771}}
==As a glucose isomerase==
{{Enzymatic Reaction
|foward_enzyme=[[Phosphoglucose isomerase]]
|reverse_enzyme=[[Phosphoglucose isomerase]]
|substrate=<small>D</small>-[[Glucose]]
|product=<small>D</small>-[[Fructose]]
|reaction_direction_(foward/reversible/reverse)=reversible
|minor_foward_substrate(s)=
|minor_foward_product(s)=
|minor_reverse_substrate(s)=
|minor_reverse_product(s)=
|substrate_image=D-glucose_wpmp.png
|product_image=D-fructose_wpmp.png
}}
==Other functions==
There is evidence that phosphoglucose isomerase acts as a molecular messenger. It is produced and secreted by [[white blood cells]], and acts to regulate the growth of several different cell types.
{{glycolysis}}
{{Gluconeogenesis}}
{{Glycolysis enzymes}}
{{Intramolecular oxidoreductases}}
{{metabolism-stub}}
[[Category:EC 5.3.1]]
{{isomerase-stub}}
[[es:Glucosa-6-fosfato isomerasa]]
[[fr:Glucose isomérase]]
[[ja:グルコースリン酸イソメラーゼ]]
[[zh:磷酸葡萄糖異構酶]]