Glucose-6-phosphate isomerase 1936865 210655259 2008-05-06T20:58:21Z Rockfang 5403270 changing stub name per [[Wikipedia:Stub_types_for_deletion/Log/2008/March/19|SfD]] , typos fixed: Km → km using [[Project:AutoWikiBrowser|AWB]] {{Protbox | Name =Glucose phosphate isomerase |Photo=Glucose-6-phosphate isomerase 1GZV wpmp.png |Caption={{{!}} align="center" border="0" {{!}} '''Enzyme''' {{!}} Glucose-6-phosphate isomerase {{!}}- {{!}} '''PDB Code''' {{!}} {{PDB|1GZV}} {{!}}- {{!}} '''Organism''' {{!}} [[Pig]] {{!}}- {{!}} '''Tissue''' {{!}} [[Muscle]] {{!}}- {{!}} '''Complexed molecules''' {{!}} [[5-phosphoarabinoate]] {{!}}} | HGNCid = 4458 | Symbol = GPI |AltSymbols = | Chromosome = 19 | Arm = q | Band = 13.1 | LocusSupplementaryData = |Gene= |Gene_type= |Protein_length= |Molecular_weight= |Structure= |Type= |Functions= |Domains= |Motifs= |Alternative_products= |Catalytic_activity= |Cofactors= |Enzyme_regulation= |km= |Vmax= |Biophysicochemical_properties= |Diseases= |Pharmaceuticals= |Biotechnology= |Taxa= |Cells= |Location= |Mods= |Names= |Pathways= |Interactions= |Actions= |Agonists= |Antagonists= |Accession_numbers= | EntrezGene = 2821 | OMIM = 172400 | RefSeq = NM_000175 | UniProt = P06744 |PDB = | ECnumber = 5.3.1.9 |Codes= |Review= |Pages= }} '''Glucose-6-phosphate isomerase''', or '''phosphoglucose isomerase''', is an [[enzyme]] ({{EC number|5.3.1.9}}) that catalyzes the conversion of [[glucose-6-phosphate]] into [[fructose-6-phosphate]] in the second step of [[glycolysis]]. An unrelated enzyme, [[D-xylose isomerase]] ({{EC number|5.3.1.5}}) catalyzes the isomerization of [[glucose]] to [[fructose]], and is sometimes called "glucose isomerase". The human variant of this enzyme is encoded by the [[GPI (gene)|GPI]] [[gene]]. ==In glycolysis== {{Enzymatic Reaction |foward_enzyme=[[Phosphoglucose isomerase]] |reverse_enzyme=[[Phosphoglucose isomerase]] |substrate=α-<small>D</small>-[[Glucose 6-phosphate]] |product=β-<small>D</small>-[[Fructose 6-phosphate]] |reaction_direction_(foward/reversible/reverse)=reversible |minor_foward_substrate(s)= |minor_foward_product(s)= |minor_reverse_substrate(s)= |minor_reverse_product(s)= |substrate_image=Glucose-6-phosphate_wpmp.png |product_image=Fructose-6-phosphate_wpmp.png }} {{KEGG compound|C00668}} {{KEGG enzyme|5.3.1.9}} {{KEGG compound|C05345}} {{KEGG reaction|R00771}} ==As a glucose isomerase== {{Enzymatic Reaction |foward_enzyme=[[Phosphoglucose isomerase]] |reverse_enzyme=[[Phosphoglucose isomerase]] |substrate=<small>D</small>-[[Glucose]] |product=<small>D</small>-[[Fructose]] |reaction_direction_(foward/reversible/reverse)=reversible |minor_foward_substrate(s)= |minor_foward_product(s)= |minor_reverse_substrate(s)= |minor_reverse_product(s)= |substrate_image=D-glucose_wpmp.png |product_image=D-fructose_wpmp.png }} ==Other functions== There is evidence that phosphoglucose isomerase acts as a molecular messenger. It is produced and secreted by [[white blood cells]], and acts to regulate the growth of several different cell types. {{glycolysis}} {{Gluconeogenesis}} {{Glycolysis enzymes}} {{Intramolecular oxidoreductases}} {{metabolism-stub}} [[Category:EC 5.3.1]] {{isomerase-stub}} [[es:Glucosa-6-fosfato isomerasa]] [[fr:Glucose isomérase]] [[ja:グルコースリン酸イソメラーゼ]] [[zh:磷酸葡萄糖異構酶]]